3α-Hydroxytibolone

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3α-Hydroxytibolone
3α-Hydroxytibolone.svg
Clinical data
Synonyms ORG-4094; 7α-Methyl-17α-ethynylestr-5(10)-ene-3α,17β-diol
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
Formula C21H30O2
Molar mass 314.469 g/mol
3D model (JSmol)

3α-Hydroxytibolone (developmental code name ORG-4094) is a synthetic steroidal estrogen which was never marketed.[1][2] Along with 3β-hydroxytibolone and δ4-tibolone, it is a major active metabolite of tibolone, and 3α-hydroxytibolone and 3β-hydroxytibolone are thought to be responsible for the estrogenic activity of tibolone.[1][2]

References[edit]

  1. ^ a b Kuhl, H (2009). "Pharmacology of estrogens and progestogens: influence of different routes of administration". Climacteric. 8 (sup1): 3–63. doi:10.1080/13697130500148875. ISSN 1369-7137. PMID 16112947. 
  2. ^ a b Escande A, Servant N, Rabenoelina F, Auzou G, Kloosterboer H, Cavaillès V, Balaguer P, Maudelonde T (2009). "Regulation of activities of steroid hormone receptors by tibolone and its primary metabolites". J. Steroid Biochem. Mol. Biol. 116 (1-2): 8–14. doi:10.1016/j.jsbmb.2009.03.008. PMID 19464167.