3-Hydroxybutyrate dehydrogenase

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3-Hydroxybutyrate dehydrogenase
Identifiers
EC number 1.1.1.30
CAS number 9028-38-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) is an enzyme that catalyzes the chemical reaction:

(R)-3-hydroxybutanoate + NAD+ acetoacetate + NADH + H+

Thus, the two substrates of this enzyme are (R)-3-hydroxybutanoate and NAD+, whereas its three products are acetoacetate, NADH, and H+. This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.

This enzyme participates in the synthesis and degradation of ketone bodies and the metabolism of butyric acid.

Synonyms[edit]

The systematic name of this enzyme class is (R)-3-hydroxybutanoate:NAD+ oxidoreductase. Other names in common use include:

  • NAD+-β-hydroxybutyrate dehydrogenase
  • hydroxybutyrate oxidoreductase
  • β-hydroxybutyrate dehydrogenase
  • D-β-hydroxybutyrate dehydrogenase
  • D-3-hydroxybutyrate dehydrogenase
  • D-(–)-3-hydroxybutyrate dehydrogenase
  • β-hydroxybutyric acid dehydrogenase
  • 3-D-hydroxybutyrate dehydrogenase
  • β-hydroxybutyric dehydrogenase

Structural studies[edit]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1WMB and 1X1T.

See also[edit]

References[edit]