3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase

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3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase
EC number
CAS number 9030-79-9
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase (EC, D-3-hydroxydecanoyl-[acyl-carrier protein] dehydratase, 3-hydroxydecanoyl-acyl carrier protein dehydrase, 3-hydroxydecanoyl-acyl carrier protein dehydratase, beta-hydroxydecanoyl thioester dehydrase, beta-hydroxydecanoate dehydrase, beta-hydroxydecanoyl thiol ester dehydrase, FabA, beta-hydroxyacyl-acyl carrier protein dehydratase, HDDase, beta-hydroxyacyl-ACP dehydrase, (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] hydro-lyase) is an enzyme with systematic name (3R)-3-hydroxydecanoyl-(acyl-carrier protein) hydro-lyase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction

(1) a (3R)-3-hydroxydecanoyl-[acyl-carrier protein] a trans-dec-2-enoyl-[acyl-carrier protein] + H2O
(2) a (3R)-3-hydroxydecanoyl-[acyl-carrier protein] a cis-dec-3-enoyl-[acyl-carrier protein] + H2O

This enzyme is specific for C10 chain length.


  1. ^ Kass LR, Brock DJ, Bloch K (October 1967). "Beta-hydroxydecanoyl thioester dehydrase. I. Purification and properties". The Journal of Biological Chemistry. 242 (19): 4418–31. PMID 4863739.
  2. ^ Brock DJ, Kass LR, Bloch K (October 1967). "Beta-hydroxydecanoyl thioester dehydrase. II. Mode of action". The Journal of Biological Chemistry. 242 (19): 4432–40. PMID 4863740.
  3. ^ Sharma A, Henderson BS, Schwab JM, Smith JL (March 1990). "Crystallization and preliminary X-ray analysis of beta-hydroxydecanoyl thiol ester dehydrase from Escherichia coli". The Journal of Biological Chemistry. 265 (9): 5110–2. PMID 2180957.
  4. ^ Magnuson K, Jackowski S, Rock CO, Cronan JE (September 1993). "Regulation of fatty acid biosynthesis in Escherichia coli". Microbiological Reviews. 57 (3): 522–42. PMC 372925. PMID 8246839.
  5. ^ Bloch K (1969). "Enzymatic synthesis of monounsaturated fatty acids". Acc. Chem. Res. 2: 193–202. doi:10.1021/ar50019a001.
  6. ^ Wang H, Cronan JE (August 2004). "Functional replacement of the FabA and FabB proteins of Escherichia coli fatty acid synthesis by Enterococcus faecalis FabZ and FabF homologues". The Journal of Biological Chemistry. 279 (33): 34489–95. doi:10.1074/jbc.M403874200. PMID 15194690.
  7. ^ Cronan JE, Rock CO (1996). "Biosynthesis of membrane lipids". In Neidhardt, F.C. Escherichia coli and Salmonella: Cellular and Molecular Biology. 1 (2nd ed.). Washington, DC: ASM Press. pp. 612–636.

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