3-hydroxyoctanoyl-(acyl-carrier-protein) dehydratase

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase
Identifiers
EC number 4.2.1.59
CAS number 9030-85-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59) is an enzyme that catalyzes the chemical reaction

(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] oct-2-enoyl-[acyl-carrier-protein] + H2O

Hence, this enzyme has one substrate, (3R)-3-hydroxyoctanoyl-(acyl-carrier-protein), and two products, [[oct-2-enoyl-[acyl-carrier-protein]]] and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase (oct-2-enoyl-[acyl-carrier protein]-forming). Other names in common use include D-3-hydroxyoctanoyl-[acyl carrier protein] dehydratase, D-3-hydroxyoctanoyl-acyl carrier protein dehydratase, beta-hydroxyoctanoyl-acyl carrier protein dehydrase, beta-hydroxyoctanoyl thioester dehydratase, beta-hydroxyoctanoyl-ACP-dehydrase, and (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase.

References[edit]

  • Mizugaki M, Swindell AC, Wakil SJ (1968). "Intermediate- and long-chain beta-hydroxyacyl-ACP dehydrases from E coli fatty acid synthetase". Biochem. Biophys. Res. Commun. 33 (3): 520–7. doi:10.1016/0006-291X(68)90607-4. PMID 4881058.