4,4'-Diapophytoene desaturase

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4,4'-diapophytoene desaturase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

4,4'-Diapophytoene desaturase (EC, dehydrosqualene desaturase, CrtN, 4,4'-diapophytoene:FAD oxidoreductase) is an enzyme with systematic name 15-cis-4,4'-diapophytoene:FAD oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction

15-cis-4,4'-diapophytoene + 4 FAD all-trans-4,4'-diapolycopene + 4 FADH2 (overall reaction)
(1a) 15-cis-4,4'-diapophytoene + FAD all-trans-4,4'-diapophytofluene + FADH2
(1b) all-trans-4,4'-diapophytofluene + FAD all-trans-4,4'-diapo-zeta-carotene + FADH2
(1c) all-trans-4,4'-diapo-zeta-carotene + FAD all-trans-4,4'-diaponeurosporene + FADH2
(1d) all-trans-4,4'-diaponeurosporene + FAD all-trans-4,4'-diapolycopene + FADH2

This enzyme is typical of Staphylococcus aureus and some other bacteria such as Heliobacillus sp.


  1. ^ Wieland, B.; Feil, C.; Gloria-Maercker, E.; Thumm, G.; Lechner, M.; Bravo, J.M.; Poralla, K.; Gotz, F. (1994). "Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4′-diaponeurosporene of Staphylococcus aureus". J. Bacteriol. 176 (24): 7719–7726. PMC 197231. PMID 8002598.
  2. ^ Raisig, A.; Sandmann, G. (1999). "4,4′-diapophytoene desaturase: catalytic properties of an enzyme from the C30 carotenoid pathway of Staphylococcus aureus". J. Bacteriol. 181 (19): 6184–6187. PMC 103650. PMID 10498735.
  3. ^ Raisig, A.; Sandmann, G. (2001). "Functional properties of diapophytoene and related desaturases of C30 to C40 carotenoid biosynthetic pathways". Biochim. Biophys. Acta. 1533 (2): 164–170. doi:10.1016/s1388-1981(01)00154-8. PMID 11566453.

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