4-oxalmesaconate hydratase

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4-oxalmesaconate hydratase
Identifiers
EC number 4.2.1.83
CAS number 85204-95-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a 4-oxalmesaconate hydratase (EC 4.2.1.83) is an enzyme that catalyzes the chemical reaction

2-hydroxy-4-oxobutane-1,2,4-tricarboxylate (E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H2O

Hence, this enzyme has one substrate, 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate, and two products, (E)-4-oxobut-1-ene-1,2,4-tricarboxylate and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds, the systematic name of this enzyme class is 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase [(E)-4-oxobut-1-ene-1,2,4-tricarboxylate-forming]. Other names in common use include 4-carboxy-2-oxohexenedioate hydratase, 4-carboxy-2-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase, oxalmesaconate hydratase, gamma-oxalmesaconate hydratase, 4-carboxy-2-oxohexenedioate hydratase, and 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase. This enzyme participates in benzoate degradation via hydroxylation.

References[edit]

  • Maruyama K (February 1983). "Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase". J. Biochem. Tokyo. 93 (2): 557–65. PMID 6841353.