5-Hydroxytryptamine receptor 4 is a protein that in humans is encoded by the HTR4 gene. This gene is a member of the family of human serotonin receptors, which are G protein-coupled receptors that stimulate cAMP production in response to serotonin; the gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described, but the full-length nature of some transcript variants has not been determined; the receptor is located in the alimentary tract, urinary bladder and adrenal gland as well as the central nervous system. In the CNS the receptor appears in the putamen, caudate nucleus, nucleus accumbens, globus pallidus, substantia nigra, to a lesser extent in the neocortex, pontine nuclei, some areas of the thalamus, it has not been found in the cerebellum. Internalization is isoform-specific.
Several drugs that act as 5-HT4 selective agonists have been introduced into use in both scientific research and clinical medicine. Some drugs that act as 5-HT4 agonists are active as 5-HT3 antagonists, such as mosapride, metoclopramide and zacopride, so these compounds cannot be considered selective. Research in this area is ongoing. SB-207,145 radiolabeled with carbon-11 is used as a radioligand for 5-HT4 in positron emission tomography pig and human studies. BIMU-8 Cisapride CJ-033,466 - partial agonist ML-10302 Mosapride Prucalopride Renzapride RS-67506 RS-67333 - partial agonist SL65.0155 - partial agonist Tegaserod Zacopride Metoclopramide Sulpiride Piboserod GR-113,808 GR-125,487 RS-39604 SB-203,186 SB-204,070 methyl 4-amino-3-methoxybenzoate Chamomile 5-HT receptor 5-HT1 receptor 5-HT2 receptor 5-HT3 receptor 5-HT5 receptor 5-HT6 receptor 5-HT7 receptor "5-HT4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Human HTR4 genome location and HTR4 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, in the public domain
The Västmanland Regiment, designations I 18 and Fo 48, was a Swedish Army infantry regiment that traced its origins back to the 16th century. It was disbanded for the first time in 1927 but reraised and disbanded again in 1997; the regiment's soldiers were recruited from the province of Västmanland, it was garrisoned there. The regiment has its origins in fänikor raised in Västmanland in the 1560s. In 1617, these units—along with fänikor from the nearby provinces of Dalarna and Uppland—were organised by Gustav II Adolf into Upplands storregemente, of which six of the total 24 companies were recruited in Västmanland. Upplands storregemente consisted of three field regiments. Sometime around 1623, the grand regiment was permanently split into three smaller regiments, of which Västmanland Regiment was one; the regiment was raised in 1628 although it had existed since 1623. Västmanland Regiment was one of the original 20 Swedish infantry regiments mentioned in the Swedish constitution of 1634; the regiment's first commander was Bengt Bagge.
It was allotted in 1682 as one of the first regiments to be so. The regiment was given the designation I 18 in a general order in 1816. Västmanland Regiment was garrisoned in Västerås from 1906; the regiment was disbanded in 1927, but was reorganised in 1994 as a local defence area with the designation Fo 48, although disbanded again just three years in 1997. The Polish War The Thirty Years' War The Northern Wars The Scanian War The Great Northern War The Hats' Russian War The Seven Years' War The Gustav III's Russian War The Finnish War The Second War against Napoleon The regiment was presented with its last colours in 1859, which it received at Ladugardsgärdet in Stockholm, it was used until the regiment was disbanded in 1927. The colour came after a government decision to be used by the Västmanland Air Force Wing. Västmanland Air Force Wing took over the colour on 26 September 1943, which included the regimental battle honours, it became Sweden's only air force wing with battle honours on its colour.
The colour was used until Västmanland Air Force Wing was disbanded in 1983. The new regiment, raised on 1 July 1994, sought its traditions Västmandland Regiment, disbanded in 1927. However, the regiment received a new colour; the colour was presented to the Västmanland Regiment in Västerås by the Chief of the Army, lieutenant general Åke Sagrén in 1994. It was used as regimental colour by Fo 48 until 1 September 1997; the colour was drawn by Ingrid Lamby and embroidered by machine in insertion technique by Gunilla Hjort. Blazon: "On white cloth the provincial badge of Västmanland. On a blue border at the upper side of the colour, battle honours in white." The coat of the arms of the Västmanland Regiment 1994–1997 and the Västmanland Group 1997–2004. Blazon: "Argent, the provincial badge of Västmanland, a three-pointed mountain azure, flammant proper; the shield surmounted two muskets in saltire or". In connection with the disbandment of Uppsala and Västmanland's Defense Area on 30 June 2000, the Uppland-Västmanlands försvarsområdes minnesmedalj in silver was established.
In 2005, the Västmanlands regementes minnesmedalj in silver was established. After the regiment was disbanded in 1997, the regimental traditions was passed on to the Västmanland Group. From 1 July 2013, the traditions are continued by the Västmanland Battalion within the Uppland and Västmanland Group; the regimental march was "Prinz Friedrich Carl-March". After the regiment was disbanded, the march was taken over by the Västmanland Air Force Wing. However, it came to be titled "Kungl Västmanlands regementes marsch"; when the new regiment was raised in 1994, the march regained its original title. Regimental commander active from 1628 to 1997. List of Swedish infantry regiments Christian. Sveriges arméförband under 1900-talet. Skrift / Statens försvarshistoriska museer, 1101-7023. Stockholm: Statens försvarshistoriska museer. ISBN 91-971584-4-5. LIBRIS 8902928. Braunstein, Christian. Svenska försvarsmaktens fälttecken efter millennieskiftet. Skrift / Statens försvarshistoriska museer, 1101-7023. Stockholm: Statens försvarshistoriska museer.
ISBN 91-971584-7-X. LIBRIS 9815350. Braunstein, Christian. Heraldiska vapen inom det svenska försvaret. Skrift / Statens försvarshistoriska museer, 1101-7023. Stockholm: Statens försvarshistoriska museer. ISBN 91-971584-9-6. LIBRIS 10099224. Kjellander, Rune. Sveriges regementschefer 1700-2000: chefsbiografier och förbandsöversikter. Stockholm: Probus. ISBN 91-87184-74-5. LIBRIS 8981272. Sandberg, Bo. Försvarets marscher och signaler förr och nu: marscher antagna av svenska militära förband, skolor och staber samt igenkännings-, tjänstgörings- och exercissignaler. Stockholm: Militärmusiksamfundet med Svenskt marscharkiv. ISBN 978-91-631-8699-8. LIBRIS 10413065. Holm, Torsten. Kungl. Västmanlands
The Giants–Jets rivalry is an American football rivalry in the National Football League between the New York Giants and New York Jets. It is an intra-city, interconference matchup between the two NFL teams based in the New York metropolitan area. Since 1984, both clubs have been the only teams in the league to share a stadium at the same time. Thus, a Giants–Jets game can be referred to as "the shortest road trip in the league", it can be referred to as a "sibling rivalry" since both teams play at and share the stadium. As the teams play in different conferences, the two teams only meet during the regular season once every four years when all four AFC East clubs play all four NFC East clubs. In addition to annual preseason matchups, the only other way the two teams would meet would be in the Super Bowl, which has never occurred; the New York Jets maintained a tense rivalry with their in-town counterparts, the New York Giants, a rivalry that has since diminished due to the infrequency with which the teams meet in the regular season.
Its origins can be traced back to the formation of the American Football League in 1960, as a rival to the more established NFL. The upstart league decided to directly compete with the NFL's Giants, granted a charter franchise to Harry Wismer, who proclaimed that New York was ready for another professional football team. Like the AFL and the NFL, their respective teams in New York fought for publicity and fans. Since the two teams play each other so infrequently in the regular season, including players on both teams, have questioned whether the Giants and Jets have a real rivalry. However, the Jets and Giants did not play each other until a preseason game at the Yale Bowl in New Haven, Connecticut, on August 17, 1969, in the lead up to the AFL–NFL merger; the game was viewed as a "turf war" by both opponents. The Giants, considered a mediocre team at the time, were regarded as underdogs and were under much scrutiny by the media and their fans; the Jets on the other hand were coming off a win in Super Bowl III as the first AFL team to win an AFL-NFL Championship Game.
The Jets won 37–14, resulting in the firing of Giants coach Allie Sherman. The teams have played in the preseason annually since. Though the annual preseason game still served as a mild opportunity for bragging rights, the fervor of the rivalry had begun to fade by 1979, it weakened further in 1990, when the Jets fired Joe Walton, a former player and coach for the Giants who had other former Giants on his staff. Another reason is that because the Jets and the Giants are in different conferences, they have only met in the regular season 11 times since the 1970 AFL–NFL merger. Under the league's current scheduling formula, in use since 2002, the two New York teams only met every four years, can only meet in the postseason if they both advance to the Super Bowl; the first regular season meeting between the two teams came in the first full post-merger season, 1970, in which the Giants beat the Jets 22-10 at Shea Stadium. When the Jets left Shea Stadium and moved to Giants Stadium for the 1984 NFL season, many Jets fans hoped the name would be changed, however the Giants, who had the authority to approve the change, refused.
Many Jets refused to refer to the stadium by its official name, instead calling it "The Meadowlands". The naming of the stadium has played a role as the Giants overshadowed the Jets; the move meant that both the Giants and Jets did not play within the city of their home market, as they have been located in neighboring New Jersey since 1984. The Jets met the Giants in 1988 during the final game of the regular season; the Jets, with a 7–7–1 record, had little to lose as their hopes for playoff contention had vanished. The Giants, were contending for a playoff spot and a victory would have secured their spot and their division title. Although the six point favorites, the Giants were unable to overcome the Jets defense which saw the Jets sack quarterback Phil Simms eight times. With the Jets' victory and victories by the Rams and Eagles, the Giants were eliminated from playoff contention and the Jets gained what many considered respect. Over the twenty six years since the Jets were accepted into their NFC counterpart's homefield.
As part of the naming rights agreement, the preseason matchup between the Giants and Jets has been renamed the "MetLife Bowl/Snoopy Bowl". On December 6, 2015, Jets and Giants played in MetLife Stadium with Giants as the official home team. Jets entered 6-5 and chasing an AFC wildcard spot while the Giants entered 5-6 and were fighting for the top seed in the NFC East. Giants had won the last five meetings between the clubs, the last two were critical for the Giants' championship runs. After each teams started with one failed possession the Jets led a 78-yard drive with several strong runs by Chris Ivory and finished with a field goal. A couple of possessions in the second quarter as both teams were stagnant on offense Dwayne Harris returned a Jets punt for an 80-yard touchdown. Jets next possession Chris Ivory fumbled the ball in the Jets red zone but Giants failed to capitalize and only got a field goal out of the opportunity. Jets had another strong drive that ended with a 25-yard pass touchdown pass from Ryan Fitzpatrick to Bilal Powell.
Giants star wide receiver Odell Beckham Jr. caught a 72-yard touchdown pass on the next Giants drive to take