6-Hydroxymelatonin

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6-Hydroxymelatonin
6-Hydroxymelatonin structure.svg
Names
IUPAC name
N-[2-(6-Hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide
Other names
6-Oxymelatonin
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.164.426
KEGG
Properties
C13H16N2O3
Molar mass 248.28 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

6-Hydroxymelatonin (6-OHM) is a naturally occurring, endogenous, major active metabolite of the neurotransmitter melatonin.[1] Similar to melatonin, 6-OHM is a full agonist of the MT1 and MT2 receptors.[2][3] It is also an antioxidant and neuroprotective, and is even more potent in this regard relative to melatonin.[4][5]

See also[edit]

References[edit]

  1. ^ Hardeland R (2010). "Melatonin metabolism in the central nervous system". Curr Neuropharmacol. 8 (3): 168–81. doi:10.2174/157015910792246244. PMC 3001211Freely accessible. PMID 21358968. 
  2. ^ Dubocovich ML (1988). "Pharmacology and function of melatonin receptors". FASEB J. 2 (12): 2765–73. PMID 2842214. 
  3. ^ Browning, Christopher; Beresford, Isabel; Fraser, Neil; Giles, Heather (2000). "Pharmacological characterization of human recombinant melatonin mt1and MT2receptors". British Journal of Pharmacology. 129 (5): 877–886. doi:10.1038/sj.bjp.0703130. ISSN 0007-1188. PMC 1571913Freely accessible. PMID 10696085. 
  4. ^ Maharaj DS, Glass BD, Daya S (2007). "Melatonin: new places in therapy". Biosci. Rep. 27 (6): 299–320. doi:10.1007/s10540-007-9052-1. PMID 17828452. 
  5. ^ Álvarez-Diduk R, Galano A, Tan DX, Reiter RJ (2015). "N-Acetylserotonin and 6-Hydroxymelatonin against Oxidative Stress: Implications for the Overall Protection Exerted by Melatonin". J Phys Chem B. 119: 8535–43. doi:10.1021/acs.jpcb.5b04920. PMID 26079042.