The 69th Infantry Regiment is an infantry regiment of the United States Army. It is from New York City, part of the New York Army National Guard. It is known as the "Fighting Sixty-Ninth", a name said to have been given by Robert E. Lee during the Civil War. An Irish-American heritage is attributed to the regiment, which is also nicknamed the "Fighting Irish" – a tradition mentioned in Joyce Kilmer's poem "When the 69th Comes Back". Between 1917 and 1992 it was also designated the 165th Infantry Regiment. It is headquartered at the 69th Regiment Armory in Manhattan.

The New York Army National Guard is a component of the New York National Guard and the Army National Guard. Nationwide, the Army National Guard comprises approximately one half of the United States Army's available combat forces and approximately one third of its support organization. National coordination of various state National Guard units are maintained through the National Guard Bureau.