8,9-Dehydroestrone

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8,9-Dehydroestrone
8,9-Dehydroestrone.svg
Clinical data
Synonyms Δ8-Estrone; Estra-1,3,5(10),8-tetraen-3-ol-17-one
Routes of
administration
By mouth
Drug class Estrogen
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
Formula C18H20O2
Molar mass 268.350 g/mol
3D model (JSmol)

8,9-Dehydroestrone, or Δ8-estrone, also known as estra-1,3,5(10),8-tetraen-3-ol-17-one, is a naturally occurring steroidal estrogen found in horses which is closely related to equilin, equilenin, and estrone, and, as the 3-sulfate ester sodium salt, is a minor constituent (3.5%) of conjugated estrogens (Premarin).[1] It produces 8,9-dehydroestradiol as an important active metabolite, analogously to conversion of estrone or estrone sulfate into estradiol.[2]

See also[edit]

References[edit]

  1. ^ Marc A. Fritz; Leon Speroff (28 March 2012). Clinical Gynecologic Endocrinology and Infertility. Lippincott Williams & Wilkins. pp. 751–. ISBN 978-1-4511-4847-3. 
  2. ^ Kuhl H (2005). "Pharmacology of estrogens and progestogens: influence of different routes of administration". Climacteric. 8 Suppl 1: 3–63. doi:10.1080/13697130500148875. PMID 16112947.