9,12-octadecadienoate 8-hydroperoxide 8R-isomerase

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9,12-octadecadienoate 8-hydroperoxide 8R-isomerase
Identifiers
EC number5.4.4.5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

9,12-octadecadienoate 8-hydroperoxide 8R-isomerase (EC 5.4.4.5, 5,8-LDS (bifunctional enzyme), 5,8-linoleate diol synthase (bifunctional enzyme), 8-hydroperoxide isomerase, (8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((5S,8R,9Z,12Z)-5,8-dihydroxy-9,12-octadecadienoate-forming), PpoA) is an enzyme with systematic name (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate hydroxymutase ((5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate-forming).[1][2][3] This enzyme catalyses the following chemical reaction

(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate

This enzyme contains heme.

References[edit]

  1. ^ Hoffmann I, Jernerén F, Garscha U, Oliw EH (February 2011). "Expression of 5,8-LDS of Aspergillus fumigatus and its dioxygenase domain. A comparison with 7,8-LDS, 10-dioxygenase, and cyclooxygenase". Archives of Biochemistry and Biophysics. 506 (2): 216–22. doi:10.1016/j.abb.2010.11.022. PMID 21130068.
  2. ^ Jernerén F, Garscha U, Hoffmann I, Hamberg M, Oliw EH (April 2010). "Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus". Biochimica et Biophysica Acta. 1801 (4): 503–7. doi:10.1016/j.bbalip.2009.12.012. PMID 20045744.
  3. ^ Brodhun F, Göbel C, Hornung E, Feussner I (May 2009). "Identification of PpoA from Aspergillus nidulans as a fusion protein of a fatty acid heme dioxygenase/peroxidase and a cytochrome P450". The Journal of Biological Chemistry. 284 (18): 11792–805. doi:10.1074/jbc.M809152200. PMC 2673248. PMID 19286665.

External links[edit]