AKR1B10

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AKR1B10
Protein AKR1B10 PDB 1zua.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases AKR1B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI, aldo-keto reductase family 1, member B10 (aldose reductase), aldo-keto reductase family 1 member B10
External IDs MGI: 107673 HomoloGene: 116462 GeneCards: AKR1B10
Gene location (Human)
Chromosome 7 (human)
Chr. Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for AKR1B10
Genomic location for AKR1B10
Band 7q33 Start 134,527,592 bp[1]
End 134,541,408 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020299

NM_008012

RefSeq (protein)

NP_064695

NP_032038

Location (UCSC) Chr 7: 134.53 – 134.54 Mb Chr 7: 34.35 – 34.37 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Aldo-keto reductase family 1 member B10 is an enzyme that in humans is encoded by the AKR1B10 gene.[5][6][7]

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses, it is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198074 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029762 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Hyndman DJ, Flynn TG (Oct 1998). "Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family". Biochim Biophys Acta. 1399 (2–3): 198–202. doi:10.1016/s0167-4781(98)00109-2. PMID 9765596. 
  6. ^ Cao D, Fan ST, Chung SS (Jun 1998). "Identification and characterization of a novel human aldose reductase-like gene". J Biol Chem. 273 (19): 11429–35. doi:10.1074/jbc.273.19.11429. PMID 9565553. 
  7. ^ a b "Entrez Gene: AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)". 

External links[edit]

Further reading[edit]