ASICS is a Japanese multinational corporation which produces footwear and sports equipment designed for a wide range of sports in the upper price range. The name is an acronym for the Latin phrase anima sana in corpore sano, which translates as "Healthy soul in a healthy body". In recent years their running shoes have been ranked among the top performance footwear in the market. On September 7th, 2018, ASICS has become an International Paralympic Committee official supplier; this agreement will be valid through to 2020 to benefit the Paralympic Movement. ASICS Ltd. began as Onitsuka Co. Ltd on September 1, 1949, its founder, Kihachiro Onitsuka, began manufacturing basketball shoes in his home town of Kobe, Hyogo Prefecture, Japan. Soon after the range of sports activities widened to a variety of Olympic styles used throughout the'50s,'60s and'70s by athletes worldwide. Onitsuka became renowned for the Mexico 66 design, in which the distinctive crossed stripes, now synonymous with the company brand, were featured for the first time.
In 1977, Onitsuka Tiger merged with JELENK to form ASICS Corporation. Despite the name change, a vintage range of ASICS shoes are still produced and sold internationally under the Onitsuka Tiger label. In its 2006 fiscal year, Asics generated 171 billion yen in net sales and 13 billion yen in net income. Sixty-six percent of the company's income came from the sale of sports shoes, 24% from sportswear, 10% from sports equipment. Forty-nine percent of the company's sales were in Japan, 28% in North America, 19% in Europe. On July 12, 2010, ASICS bought the Swedish outdoor brand Haglöfs, for SEK1,000,000,000. On October 4, 2011, it was announced that ASICS will be the new official kit manufacturer for the Australian Cricket Team, replacing German manufacturer Adidas. On December 12, 2018, ASICS announced the launch of an e-commerce website for the Indian market. Through this platforms, customers can make orders and payments easier; this new ASICS website will host many global top sellers, like GEL Kayano, Hyper GEL, GEL KENUN, GEL Nimbus among other popular styles, stated the release.
The name ASICS is an acronym of the Latin phrase anima sana in corpore sano which translates to "healthy soul in a healthy body" and derives from Juvenal's aphorism mens sana in corpore sano. Nike, Inc. known as Blue Ribbon Sports, was founded to sell Onitsuka Tiger shoes in the US. When Phil Knight visited Japan in 1963 shortly after he graduated from Stanford University, he was impressed by Onitsuka Tiger shoes with their high quality but reasonable prices, he visited the Onitsuka Tiger office and asked to be their sales agent in the USA. After a number of years, their relationship crumbled and both companies sued each other, with Nike retaining the naming rights to several shoes. List of swimwear brands ASICS Worldwide
Acid-sensing ion channel
Acid-sensing ion channels are neuronal voltage-insensitive sodium channels activated by extracellular protons permeable to Na+. ASIC1 shows low Ca2+ permeability. ASIC proteins are a subfamily of the ENaC/Deg superfamily of ion channels; these genes have splice variants. In mammals, acid-sensing ion channels are encoded by five genes that produce ASIC protein subunits: ASIC1, ASIC2, ASIC3, ASIC4, ASIC5. Three of these protein subunits assemble to form the ASIC, which can combine into both homotrimeric and heterotrimeric channels found in both the central nervous system and peripheral nervous system. However, the most common ASICs are ASIC1a and ASIC1a/2a and ASIC3. ASIC2b is non-functional on its own but modulates channel activity when participating in heteromultimers and ASIC4 has no known function. On a broad scale, ASICs are potential drug targets due to their involvement in pathological states such as retinal damage and ischemic brain injury; each acid-sensing ion channel is composed of a 500-560 amino acid sequence, constructed into a six transmembrane segment—two per subunit, a cytoplasmic amino-carboxyl termini, a large extracellular domain.
The intracellular amino-carboxyl termini domains are vital to the channel's intracellular protein interactions and modulations, ion permeability, gating. However, the gating and mechanics of each acid-sensing ion channel is determined by the combination of ASIC subunits that form its structure; the mechanics of the pore function is fundamental to the channel's structure. Between the three ASIC1 subunits, a tunnel extends from the top of the extracellular domains to the cytoplasm of the cell; the central tunnel runs directly between the trimeric unit, where it has large constricted areas that change in size and shape depending on channel state. The two transmembrane domains of each of the three ASIC subunits are responsible for the channel's pore. TMD2 is involved with lining of the lumen within the pore and inactivation gate of the channel, where as TMD1 holds the protein within the cell's lipid bilayer. TMD1 is connected to the β-sheets of the extracellular domain that flex to widen the extracellular domain to allow for ion passage through the channel.
In-between the TMD2 segments resides a selectivity filter that forms the narrowest part of the pore, responsible for ASIC permissibility to Na+. For ASIC1, nine amino acid residues, three contributed by each ASIC subunit, form the selectivity filter. Nicknamed the "GAS belt", all three carbonyl oxygens line the pore, producing a negative potential that contributes to the conductance of cations; the specific amino acid residue of aspartate on the extracellular side lumen of TMD2 in ASIC1 has been linked to the channel's low Ca2+ conductance. Additionally, The n-termini residues of the transmembrane region has shown selectivity for Na+, since mutations within this region has altered function and of Na+ conductance. ASIC's have a fist-like extracellular region that consumes most of the proteins structure. Within its "fist-like" structure there is a wrist, finger, thumb and β-ball domains; the "palm" makes up most of the extracellular domain, formed by seven β-sheets, where as the rest of the secondary structural domains are composed of α-helical segments.
Distinguished by its specific amino acid configurations, the extracellular region is fundamental to the induction of activation/inactivation along with pH gating. The specific β-sheet loop area between the "palm" and "thumb" domains has shown involvement in the signal transduction from the extracellular domain to the transmembrane regions, resulting in a conformational change of the ASIC to its open state. However, it remains inconclusive of which particular residues interact with protons to activate the channel. In 2009, studies may have established a relationship between the aromatic residues Tyr72, Pro287, Trp288 and proton-gating of the ASIC; these residues form an acidic pocket that express electrostatic potentials that are responsible for pH-dependency in channel activation and modulation. This pocket in the extracellular domain acts as a reserve for cations to concentrate to further assist in Na+ influx. Glycosylation is apparent within the extracellular region, playing an important role in the trafficking the channel to the membrane's surface as well as establishing the ASIC's sensitivity to pH levels.
Further experimental evidence has indicated that Ca2+ may play a pivotal role in modulating proton affinity of ASIC gating both within the pore and on the extracellular domain. The role of the ASIC is to sense reduced levels of extracellular pH and result in a response or signal from the neuron; the ligand that binds to the activation site has long been thought to be protons. Under increased acidic conditions, a proton binds to the channel in the extracellular region, activating the ion channel to go through conformational change therefore opening transmembrane domain 2; this results in the influx of sodium ions through the lumen of TMD2. All ASICs are permeable to sodium ions; the only variant is ASIC1a which has a low permeability to calcium ions. The influx of these cations results in membrane depolarization. Voltage-gated Ca2+ channels are activated resulting in an influx of calcium into the cell; this causes depolarization of an excitatory response released. In ASIC1a, Ca2+ increase inside the cell is a result of calcium influx directly through the channel.
Once activated the ASIC can go on to t
Hyperdimension Neptunia mk2
Hyperdimension Neptunia mk2 is a 2011 role-playing video game developed by Idea Factory and Compile Heart, with assistance from Nippon Ichi Software, Gust Corporation, 5pb. and the founded company Comcept by Keiji Inafune. It is the sequel to the previous game named Hyperdimension Neptunia, announced on April 12, 2011 for the PlayStation 3, as the second installment in the Hyperdimension Neptunia franchise, is followed by Hyperdimension Neptunia Victory, it was released on August 18, 2011 in Japan, was released in February 2012 in the United States and Europe. This is the first and so far only game in the series to receive a Mature rating from the ESRB in North America; the sequel contains both new and returning characters, the gameplay has been updated so as to remove the random encounter feature. New maps and a brand new world feature as well, the cutscenes have been upgraded from the old 2D visual novel style cutscenes. Hyperdimension Neptunia Mk2 was made available as a downloadable title on the PlayStation Network in August 2012.
A portable remaster titled Hyperdimension Neptunia Re. It was released on 20 March 2014 in Japan, in January 2015 in North America and Europe. Re. While in a dungeon, various actions can be performed the Treasure Search and the Symbol Attack; when the O button is pressed, the player scans the area to find hidden treasure. Enemies now wander the map, when the player character comes within their sight range, a red exclamation point will appear, they will chase the player. Hitting it with a Symbol Attack gives the player's party the upper hand, may sometimes defeat the enemy. If the latter occurs, no rewards are gained. If the player character is approached from behind, the battle will start with a Back Attack and the enemy will gain the advantage. Other items within dungeons include Sharicite Symbols that trigger events, Save Points, Common Items, Gathering Points that release ingredients for item synthesis, a dungeon exit; when the player comes in contact with an enemy on the field or during an event, battle starts.
Each character's turn is gauged by their Action Points. Normal attacks and items consume AP until the points run out; each character is assigned SP, or Skill Points, for performing skills or activating HDD in the case of the CPUs or the CPU Candidates. Skills vary in range and attack power. One skill can be used per turn, after which the character's turn ends, regardless of current AP remaining. HDD requires 100 SP to activate; this is done by using the HDD ON command, once activated, the character will consume SP until it runs out, after which the character will revert. Up to 100 SP can be carried in between battles. Movement is gauged by a blue circle around the character; this marks the area within. Certain normal moves may shorten this circle; the turn order of the battle is controlled with the Agility stat. The higher a character's Agility, the sooner their turn will come; the command menu is used for performing various actions. The character may use skills, activate HDD, or end their turn, they may switch between standby characters using AP and SP, escape from unscripted battles, or use items.
As in the first game, draining an enemy's GP, or Guard Points, forces that target into Guard Break mode. In this state, the defense stat and resistances of the target are reduced until the enemy's GP recovers. GP depletes faster. Normal combos can be edited by inserting extra commands; these commands appear after the first normal attack. Normal combos branch off into three types: Rush, Heavy Hits, Break. Rush attacks involve high hit counts. Heavy Hits deplete enemy HP faster. Break attacks deplete enemy GP faster. By executing certain commands in specific patterns and consuming a set amount of AP, a combo finisher called an EX Finish is performed; the type of EX Finish is related to the command used to execute it. Status conditions can affect combat. Whenever a target is affected by Poison, they continuously receive 1/16th of their max health in damage. Heal continuously recovers 1/16th of their max health instead; when affected by Skillseal, Skills are disabled. When affected by Paralysis, the character is immobile and their turn is skipped.
When a CPU or CPU Candidate is affected by Virus, the HDD ON command becomes locked, if the target is in HDD, they forcibly revert. The Chirper serves as the main communication system in each landmass; this allows the player to view. NPCs with chat bubbles highlighted in purple indicate events; when the player visits the Guild located in each landmass, they may accept quests. The quest types range between defeating a certain number of enemies to collecting a certain number of items. Once a quest is completed and reported, the player receives rewards denoted by the posted quest, the CPU Shares for that city are altered. Item synthesis can take place in every landmass. Once the recipe for a certain item is obtained, the player may craft that item in the synthesis shop by consuming the required ingredients that a recipe calls for. In some cases, to synthesize an item, a specific ch
Application-specific integrated circuit
An application-specific integrated circuit is an integrated circuit customized for a particular use, rather than intended for general-purpose use. For example, a chip designed to run in a digital voice recorder or a high-efficiency bitcoin miner is an ASIC. Application-specific standard products are intermediate between ASICs and industry standard integrated circuits like the 7400 series or the 4000 series; as feature sizes have shrunk and design tools improved over the years, the maximum complexity possible in an ASIC has grown from 5,000 logic gates to over 100 million. Modern ASICs include entire microprocessors, memory blocks including ROM, RAM, EEPROM, flash memory and other large building blocks; such an ASIC is termed a SoC. Designers of digital ASICs use a hardware description language, such as Verilog or VHDL, to describe the functionality of ASICs. Field-programmable gate arrays are the modern-day technology for building a breadboard or prototype from standard parts. For smaller designs or lower production volumes, FPGAs may be more cost effective than an ASIC design in production.
The non-recurring engineering cost of an ASIC can run into the millions of dollars. Therefore, device manufacturers prefer FPGAs for prototyping and devices with low production volume and ASICs for large production volumes where NRE costs can be amortized across many devices; the initial ASICs used gate array technology. An early successful commercial application was the gate array circuitry found in the low-end 8-bit ZX81 and ZX Spectrum personal computers, introduced in 1981 and 1982; these were used by Sinclair Research as a low-cost I/O solution aimed at handling the computer's graphics. Customization occurred by varying a metal interconnect mask. Gate arrays had complexities of up to a few thousand gates. Versions became more generalized, with different base dies customized by both metal and polysilicon layers; some base dies include random-access memory elements. In the mid-1980s, a designer would choose an ASIC manufacturer and implement their design using the design tools available from the manufacturer.
While third-party design tools were available, there was not an effective link from the third-party design tools to the layout and actual semiconductor process performance characteristics of the various ASIC manufacturers. Most designers used factory-specific tools to complete the implementation of their designs. A solution to this problem, which yielded a much higher density device, was the implementation of standard cells; every ASIC manufacturer could create functional blocks with known electrical characteristics, such as propagation delay and inductance, that could be represented in third-party tools. Standard-cell design is the utilization of these functional blocks to achieve high gate density and good electrical performance. Standard-cell design is intermediate between § Gate-array and semi-custom design and § Full-custom design in terms of its non-recurring engineering and recurring component costs as well as performance and speed of development. By the late 1990s, logic synthesis tools became available.
Such tools could compile HDL descriptions into a gate-level netlist. Standard-cell integrated circuits are designed in the following conceptual stages referred to as electronics design flow, although these stages overlap in practice: Requirements engineering: A team of design engineers starts with a non-formal understanding of the required functions for a new ASIC derived from requirements analysis. Register-transfer level design: The design team constructs a description of an ASIC to achieve these goals using a hardware description language; this process is similar to writing a computer program in a high-level language. Functional verification: Suitability for purpose is verified by functional verification; this may include such techniques as logic simulation through test benches, formal verification, emulation, or creating and evaluating an equivalent pure software model, as in Simics. Each verification technique has advantages and disadvantages, most several methods are used together for ASIC verification.
Unlike most FPGAs, ASICs cannot be reprogrammed once fabricated and therefore ASIC designs that are not correct are much more costly, increasing the need for full test coverage. Logic synthesis: Logic synthesis transforms the RTL design into a large collection called of lower-level constructs called standard cells; these constructs are taken from a standard-cell library consisting of pre-characterized collections of logic gates performing specific functions. The standard cells are specific to the planned manufacturer of the ASIC; the resulting collection of standard cells and the needed electrical connections between them is called a gate-level netlist. Placement: The gate-level netlist is next processed by a placement tool which places the standard cells onto a region of an integrated circuit die representing the final ASIC; the placement tool attempts to find an optimized placement of the standard cells, subject to a variety of specified constraints. Routing: An electronics routing tool takes the physical placement of the standard cells and uses the netlist to create the electrical connections between them.
Since the search space is large, this process will produce a "sufficient" rather than "globally optimal" solution. The output is a file which can be used to create a set of photomasks enabling a semiconductor fabrication facility
Andrea Illy is an Italian businessman. He is the Chairman of illycaffè S.p. A. A family coffee business founded in Trieste in 1933, he has additionally been Chairman of Altagamma since 2013. Illy was born on 2 September 1964 in Trieste, Italy and is the son of Ernesto Illy, he started his studies in Switzerland and graduated with a degree in Chemistry from the University of Trieste. He subsequently took a Master Executive at SDA Bocconi, attended the six-week Advanced Management program at Harvard Business School, the Executive Program at Singularity University, Silicon Valley. In 2003, he joined the Advisory Board of SDA Bocconi. Illy has three daughters. In 1990, he joined the family business as a supervisor of the quality control department. Inspired by his previous experience in Japan, Illy started the Total Quality Program, which established standards for the company and coffee industry. In 1994 he was appointed CEO of illycaffè S.p. A. and held that position until 2016. He has been Chairman of the company since 2005.
At illycaffè, he developed several projects: The "Università del caffè" with the objective of developing and spreading the culture of coffee in the world. The retail business at global level, with 230 stores and monobrand illy. "Iperespresso" the new capsules system to prepare espresso coffee, based on a two phases extraction chamber. Illy contributed to Expo Milan 2015 by curating the Coffee Cluster, a 43,000-square foot pavilion hosting 10 coffee-producing countries, while illycaffè has been Official Coffee Partner of the Universal Exhibition. In 1996, Illy was chosen as "Marketing Superstar" by the American magazine Advertising Age. In 1999, he undertook the role of president of A. S. I. C. While today he is Honorary President. Between 2003 and 2006 he was a member of the Advisory Board of the SDA Bocconi School of Management. In 2004, he was awarded the title of "Imprenditore dell ` Anno" by Young Italia. In 2012, he co-founded the LH Forum reflection group, the Movement for the positive economy created by Jacques Attali.
From 2012 until March 2016, he was Chairman of the Promotion and Market Development Committee of the International Coffee Organization. In 2012 and 2013 he was Board member and President of the Sustainability Committee of the coffee and tea leading Dutch multinational company D. E Master Blenders 1753. Since 2013, he is part of the Board of Governors of the Bank of Italy for the seat of Trieste. In April 2013, he was elected Chairman of Fondazione Altagamma gathering High-End Italian Cultural and Creative Companies, of which he was a member of the Board of Directors since 1999 and, as a representative of the food industry, vice-president since 2007. In December 2015 he was reconfirmed as Chairman for the 2016-2018 period, he was named Cavaliere del Lavoro by the President of the Italian Republic in 2018. Illy, Andrea. Espresso coffee: the chemistry of quality. London: Academic Press. Illy, Andrea. "Espresso coffee: the science of quality". Amsterdam. Elsevier academic press. Illy, Andrea. L'aroma del mondo: un viaggio nell'universo e nell'emozione del caffè.
Milano, Hoepli. Illy, Andrea. A Coffee Dream. Torino. Codice Edizioni. Illy, Ernesto; the complexity of coffee. Scientific American, pag.10. Ernesto Illy Riccardo Illy illycaffè "Andrea Illy". Illycaffè. Archived from the original on 13 July 2011. Retrieved 9 February 2011. Davidson, Andrew. "The original Mr Bean". The Sunday Times. Retrieved 9 February 2011. Illycaffè International Website Reuters.com Bio on charitybuzz.com The Times: The original Mr Bean Bio on theguardian.com Bio on ceeman.com Bio on FT.com Bio on nytimes.com Bio on gec.co Expo Milan YT channel Usapavillion.com Bio on bbs.unibo.it ASIC official site Bio on theglobalist.com Bio on clubs.london.com LH Forum YT channel Bio on weforum.org Bio on Expo site Wwd.com Fondazione Altagamma official site The New York Times: Coffehouses as Fashion Boutiques