ATP-dependent NAD(P)H-hydrate dehydratase

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ATP-dependent NAD(P)H-hydrate dehydratase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, an ATP-dependent NAD(P)H-hydrate dehydratase (EC is an enzyme that catalyzes the chemical reaction

ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide ADP + phosphate + NADH

The 3 substrates of this enzyme are ATP, (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine, and dinucleotide, whereas its 3 products are ADP, phosphate, and NADH.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds, the systematic name of this enzyme class is (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleot ide hydro-lyase (ATP-hydrolysing; NADH-forming). Other names in common use include reduced nicotinamide adenine dinucleotide hydrate dehydratase, ATP-dependent H4NAD(P)+OH dehydratase, (6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-, and dinucleotide hydro-lyase(ATP-hydrolysing).


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