London is the capital and largest city of both England and the United Kingdom. Standing on the River Thames in the south-east of England, at the head of its 50-mile estuary leading to the North Sea, London has been a major settlement for two millennia. Londinium was founded by the Romans; the City of London, London's ancient core − an area of just 1.12 square miles and colloquially known as the Square Mile − retains boundaries that follow its medieval limits. The City of Westminster is an Inner London borough holding city status. Greater London is governed by the Mayor of the London Assembly. London is considered to be one of the world's most important global cities and has been termed the world's most powerful, most desirable, most influential, most visited, most expensive, sustainable, most investment friendly, most popular for work, the most vegetarian friendly city in the world. London exerts a considerable impact upon the arts, education, fashion, healthcare, professional services and development, tourism and transportation.
London ranks 26 out of 300 major cities for economic performance. It is one of the largest financial centres and has either the fifth or sixth largest metropolitan area GDP, it is the most-visited city as measured by international arrivals and has the busiest city airport system as measured by passenger traffic. It is the leading investment destination, hosting more international retailers and ultra high-net-worth individuals than any other city. London's universities form the largest concentration of higher education institutes in Europe. In 2012, London became the first city to have hosted three modern Summer Olympic Games. London has a diverse range of people and cultures, more than 300 languages are spoken in the region, its estimated mid-2016 municipal population was 8,787,892, the most populous of any city in the European Union and accounting for 13.4% of the UK population. London's urban area is the second most populous in the EU, after Paris, with 9,787,426 inhabitants at the 2011 census.
The population within the London commuter belt is the most populous in the EU with 14,040,163 inhabitants in 2016. London was the world's most populous city from c. 1831 to 1925. London contains four World Heritage Sites: the Tower of London. Other landmarks include Buckingham Palace, the London Eye, Piccadilly Circus, St Paul's Cathedral, Tower Bridge, Trafalgar Square and The Shard. London has numerous museums, galleries and sporting events; these include the British Museum, National Gallery, Natural History Museum, Tate Modern, British Library and West End theatres. The London Underground is the oldest underground railway network in the world. "London" is an ancient name, attested in the first century AD in the Latinised form Londinium. Over the years, the name has attracted many mythicising explanations; the earliest attested appears in Geoffrey of Monmouth's Historia Regum Britanniae, written around 1136. This had it that the name originated from a supposed King Lud, who had taken over the city and named it Kaerlud.
Modern scientific analyses of the name must account for the origins of the different forms found in early sources Latin, Old English, Welsh, with reference to the known developments over time of sounds in those different languages. It is agreed; this was adapted into Latin as Londinium and borrowed into Old English, the ancestor-language of English. The toponymy of the Common Brythonic form is much debated. A prominent explanation was Richard Coates's 1998 argument that the name derived from pre-Celtic Old European *lowonida, meaning "river too wide to ford". Coates suggested that this was a name given to the part of the River Thames which flows through London. However, most work has accepted a Celtic origin for the name, recent studies have favoured an explanation along the lines of a Celtic derivative of a proto-Indo-European root *lendh-, combined with the Celtic suffix *-injo- or *-onjo-. Peter Schrijver has suggested, on these grounds, that the name meant'place that floods'; until 1889, the name "London" applied to the City of London, but since it has referred to the County of London and Greater London.
"London" is sometimes written informally as "LDN". In 1993, the remains of a Bronze Age bridge were found on the south foreshore, upstream of Vauxhall Bridge; this bridge either reached a now lost island in it. Two of those timbers were radiocarbon dated to between 1750 BC and 1285 BC. In 2010 the foundations of a large timber structure, dated to between 4800 BC and 4500 BC, were found on the Thames's south foreshore, downstream of Vauxhall Bridge; the function of the mesolithic structure is not known. Both structures are on the south bank. Although there is evidence of scattered Brythonic settlements in the area, the first major settlement was founded by the Romans about four years after the invasion
Sydney Brenner was a South African biologist. In 2002, he shared the Nobel Prize in Physiology or Medicine with H. Robert Horvitz and Sir John E. Sulston. Brenner made significant contributions to work on the genetic code, other areas of molecular biology while working in the Medical Research Council Laboratory of Molecular Biology in Cambridge, England, he established the roundworm Caenorhabditis elegans as a model organism for the investigation of developmental biology, founded the Molecular Sciences Institute in Berkeley, United States. Brenner was born in the town of Germiston in the Transvaal, South Africa, on 13 January 1927, his parents and Morris Brenner, were Jewish immigrants. His father, a cobbler, came to South Africa from Lithuania in 1910, his mother from Riga, Latvia, in 1922, he had a sister, Phyllis. He was educated at the University of the Witwatersrand. Having joined university at the age of 15, it was noted during his second year that he would be too young to qualify for the practice of medicine at the conclusion of his six-year medical course, he was therefore allowed to complete a Bachelor of Science degree in Anatomy and Physiology.
He stayed on for two more years doing an Honours degree and an MSc degree, supporting himself by working part-time as a laboratory technician. During this time he was taught by Raymond Dart and Robert Broom, his master thesis was in the field of cytogenetics. In 1951 he received the Bachelor of Bachelor of Surgery degree. Brenner received an 1851 Exhibition Scholarship from the Royal Commission for the Exhibition of 1851 which enabled him to complete a Doctor of Philosophy degree at the University of Oxford as a postgraduate student of Exeter College, supervised by Cyril Hinshelwood. Following his DPhil, Brenner did postdoctoral research at the University of Berkeley, he spent the next 20 years at the Laboratory of Molecular Biology in Cambridge. There, during the 1960s, he contributed to molecular biology an emerging field. In 1976 he joined the Salk Institute in California. Together with Jack Dunitz, Dorothy Hodgkin, Leslie Orgel, Beryl M. Oughton, he was one of the first people in April 1953 to see the model of the structure of DNA, constructed by Francis Crick and James Watson.
All were impressed by the new DNA model Brenner who subsequently worked with Crick in the Cavendish Laboratory at the University of Cambridge and the newly opened Medical Research Council Laboratory of Molecular Biology. According to the late Beryl Oughton Rimmer, they all travelled together in two cars once Dorothy Hodgkin announced to them that they were off to Cambridge to see the model of the structure of DNA. Brenner made several seminal contributions to the emerging field of molecular biology in the 1960s; the first was to prove. This insight separated the coding function from structural constraints as proposed in a clever code by George Gamow; this led Francis Crick to propose the concept of the adaptor or as it is now known "transfer RNA". The physical separation between the anticodon and the amino acid on a tRNA is the basis for the unidirectional flow of information in coded biological systems; this is known as the central dogma of molecular biology i.e. that information flows from nucleic acid to protein and never from protein to nucleic acid.
Following this adaptor insight, Brenner proposed the concept of a messenger RNA, based on interpreting the work of Elliot "Ken" Volkin and Larry Astrachan. With Francis Crick, Leslie Barnett and Richard J. Watts-Tobin, Brenner genetically demonstrated the triplet nature of the code of protein translation through the Crick, Barnett, Watts-Tobin et al. experiment of 1961, which discovered frameshift mutations. This insight provided early elucidation of the nature of the genetic code. Leslie Barnett helped. Brenner, with George Pieczenik, created the first computer matrix analysis of nucleic acids using TRAC, which Brenner continues to use. Crick, Brenner and Pieczenik returned to their early work on deciphering the genetic code with a pioneering paper on the origin of protein synthesis, where constraints on mRNA and tRNA co-evolved allowing for a five-base interaction with a flip of the anticodon loop, thereby creating a triplet code translating system without requiring a ribosome; this model requires a overlapping code.
The published scientific paper is rare in that its collaborators include three authors who independently became Nobel laureates. Brenner focused on establishing Caenorhabditis elegans as a model organism for the investigation of animal development including neural development. Brenner chose this 1-millimeter-long soil roundworm because it is simple, is easy to grow in bulk populations, turned out to be quite convenient for genetic analysis. One of the key methods for identifying important function genes was the screen for roundworms that had some functional defect, such as being uncoordinated, leading to the identification of new sets of proteins, such as the set of UNC proteins. For this work, he shared the 2002 Nobel Prize in Physiology or Medicine with H. Robert Horvitz and John Sulston; the title of his Nobel lecture on December 2002, "Nature's Gift to Science", is a homage to this nematode.
Institut de France
The Institut de France is a French learned society, grouping five académies, including the Académie française. The Institute, located in Paris, manages 1,000 foundations, as well as museums and châteaux open for visit, it awards prizes and subsidies, which amounted to a total of over €27 million per year in 2017. Most of these prizes are awarded by the Institute on the recommendation of the académies; the building was constructed as the Collège des Quatre-Nations by Cardinal Mazarin, as a school for students from new provinces attached to France under Louis XIV. The Institut de France was established on 25 October 1795, by the French government. In 2017, Xavier Darcos was named the Institut de France's chancellor. Académie française – initiated 1635, suppressed 1793, restored 1803 as a division of the institute. Académie des inscriptions et belles-lettres – initiated 1663. Académie des sciences – initiated 1666. Académie des beaux-arts – created 1816 as the merger of the Académie de peinture et de sculpture Académie de musique and Académie d'architecture Académie des sciences morales et politiques – initiated 1795, suppressed 1803, reestablished 1832.
The Royal Society of Canada, initiated 1882, was modeled after the Institut de France and the Royal Society of London. The Lebanese Academy of Sciences, known by its French name "Académie des Sciences du Liban", is broadly fashioned after the French Academy of Sciences, with which it continues to develop joint programs. Collège des Quatre-Nations National academy List of museums in Paris List of honorary societies Media related to Institut de France at Wikimedia Commons Official website Notes on the Institut de France from the Scholarly Societies project
A primate is a eutherian mammal constituting the taxonomic order Primates. Primates arose 85–55 million years ago from small terrestrial mammals, which adapted to living in the trees of tropical forests: many primate characteristics represent adaptations to life in this challenging environment, including large brains, visual acuity, color vision, altered shoulder girdle, dexterous hands. Primates range in size from Madame Berthe's mouse lemur, which weighs 30 g, to the eastern gorilla, weighing over 200 kg. There are 190 -- 448 species of living primates, depending on. New primate species continue to be discovered: over 25 species were described in the first decade of the 2000s, eleven since 2010. Primates are divided into two distinct suborders; the first is the strepsirrhines - lemurs and lorisids. The second is haplorhines - the "dry-nosed" primates - tarsier and ape clades, the last of these including humans. Simians are monkeys and apes, cladistically including: the catarrhines consisting of the Old World monkeys and apes.
Forty million years ago, simians from Africa migrated to South America by drifting on debris, gave rise to the New World monkeys. Twenty five million years ago the remaining Old World simians split into Old World monkeys. Common names for the simians are the baboons, macaques and great apes. Primates have large brains compared to other mammals, as well as an increased reliance on visual acuity at the expense of the sense of smell, the dominant sensory system in most mammals; these features are more developed in monkeys and apes, noticeably less so in lorises and lemurs. Some primates are trichromats, with three independent channels for conveying color information. Except for apes, primates have tails. Most primates have opposable thumbs. Many species are sexually dimorphic. Primates have slower rates of development than other sized mammals, reach maturity and have longer lifespans. Depending on the species, adults may live in solitude, in mated pairs, or in groups of up to hundreds of members; some primates, including gorillas and baboons, are terrestrial rather than arboreal, but all species have adaptations for climbing trees.
Arboreal locomotion techniques used include leaping from tree to tree and swinging between branches of trees. Primates are among the most social of animals, forming pairs or family groups, uni-male harems, multi-male/multi-female groups. Non-human primates have at four types of social systems, many defined by the amount of movement by adolescent females between groups. Most primate species remain at least arboreal: the exceptions are some great apes and humans, who left the trees for the ground and now inhabit every continent. Close interactions between humans and non-human primates can create opportunities for the transmission of zoonotic diseases virus diseases, including herpes, ebola and hepatitis. Thousands of non-human primates are used in research around the world because of their psychological and physiological similarity to humans. About 60% of primate species are threatened with extinction. Common threats include deforestation, forest fragmentation, monkey drives, primate hunting for use in medicines, as pets, for food.
Large-scale tropical forest clearing for agriculture most threatens primates. The English name "primates" is derived from Old French or French primat, from a noun use of Latin primat-, from primus; the name was given by Carl Linnaeus. The relationships among the different groups of primates were not understood until recently, so the used terms are somewhat confused. For example, "ape" has been used either as an alternative for "monkey" or for any tailless human-like primate. Sir Wilfrid Le Gros Clark was one of the primatologists who developed the idea of trends in primate evolution and the methodology of arranging the living members of an order into an "ascending series" leading to humans. Used names for groups of primates such as "prosimians", "monkeys", "lesser apes", "great apes" reflect this methodology. According to our current understanding of the evolutionary history of the primates, several of these groups are paraphyletic: a paraphyletic group is one which does not include all the descendants of the group's common ancestor.
In contrast with Clark's methodology, modern classifications identify only those groupings that are monophyletic. The cladogram below shows one possible classification sequence of the living primates: groups that use common names are shown on the right. All groups with scientific names are monophyletic, the sequence of scientific classification reflects the evolution
Government of the United Kingdom
The Government of the United Kingdom, formally referred to as Her Majesty's Government, is the central government of the United Kingdom of Great Britain and Northern Ireland. It is commonly referred to as the UK Government or the British Government; the government is led by the Prime Minister. The prime minister and the other most senior ministers belong to the supreme decision-making committee, known as the Cabinet; the government ministers all sit in Parliament, are accountable to it. The government is dependent on Parliament to make primary legislation, since the Fixed-terms Parliaments Act 2011, general elections are held every five years to elect a new House of Commons, unless there is a successful vote of no confidence in the government or a two-thirds vote for a snap election in the House of Commons, in which case an election may be held sooner. After an election, the monarch selects as prime minister the leader of the party most to command the confidence of the House of Commons by possessing a majority of MPs.
Under the uncodified British constitution, executive authority lies with the monarch, although this authority is exercised only by, or on the advice of, the prime minister and the cabinet. The Cabinet members advise the monarch as members of the Privy Council. In most cases they exercise power directly as leaders of the Government Departments, though some Cabinet positions are sinecures to a greater or lesser degree; the current prime minister is Theresa May, who took office on 13 July 2016. She is the leader of the Conservative Party, which won a majority of seats in the House of Commons in the general election on 7 May 2015, when David Cameron was the party leader. Prior to this and the Conservatives led a coalition from 2010 to 2015 with the Liberal Democrats, in which Cameron was prime minister; the Government is referred to with the metonym Westminster, due to that being where many of the offices of the government are situated by members in the Government of Scotland, the Welsh Government and the Northern Ireland Executive in order to differentiate it from their own.
A key principle of the British Constitution is. This is called responsible government; the United Kingdom is a constitutional monarchy in which the reigning monarch does not make any open political decisions. All political decisions are taken by Parliament; this constitutional state of affairs is the result of a long history of constraining and reducing the political power of the monarch, beginning with Magna Carta in 1215. Parliament is split into the House of Commons; the House of Commons is the more powerful. The House of Lords is the upper house and although it can vote to amend proposed laws, the House of Commons can vote to overrule its amendments. Although the House of Lords can introduce bills, most important laws are introduced in the House of Commons – and most of those are introduced by the government, which schedules the vast majority of parliamentary time in the Commons. Parliamentary time is essential for bills to be passed into law, because they must pass through a number of readings before becoming law.
Prior to introducing a bill, the government may run a public consultation to solicit feedback from the public and businesses, may have introduced and discussed the policy in the Queen's Speech, or in an election manifesto or party platform. Ministers of the Crown are responsible to the House. For most senior ministers this is the elected House of Commons rather than the House of Lords. There have been some recent exceptions to this: for example, cabinet ministers Lord Mandelson and Lord Adonis sat in the Lords and were responsible to that House during the government of Gordon Brown. Since the start of Edward VII's reign in 1901, the prime minister has always been an elected member of Parliament and therefore directly accountable to the House of Commons. A similar convention applies to the Chancellor of the Exchequer, it would be politically unacceptable for the budget speech to be given in the Lords, with MPs unable to directly question the Chancellor now that the Lords have limited powers in relation to money bills.
The last Chancellor of the Exchequer to be a member of the House of Lords was Lord Denman, who served as interim Chancellor of the Exchequer for one month in 1834. Under the British system, the government is required by convention and for practical reasons to maintain the confidence of the House of Commons, it requires the support of the House of Commons for the maintenance of supply and to pass primary legislation. By convention, if a government loses the confidence of the House of Commons it must either resign or a General Election is held; the support of the Lords, while useful to the government in getting its legislation passed without delay, is not vital. A government is not required to resign if it loses the confidence of the Lords and is defeated in key votes in that House; the House of Commons is thus the Responsible house. The prime minister is held to account during Prime Minister's Questions which provides an opportunity for MPs from all parties to question the PM on any subject
Fellow of the Academy of Medical Sciences
Fellowship of the Academy of Medical Sciences is an award for medical scientists who are judged by the Academy of Medical Sciences for the "excellence of their science, their contribution to medicine and society and the range of their achievements". Fellows are entitled to use the post-nominal letters FMedSci.
Health policy can be defined as the "decisions and actions that are undertaken to achieve specific healthcare goals within a society". According to the World Health Organization, an explicit health policy can achieve several things: it defines a vision for the future. There are many categories of health policies, including global health policy, public health policy, mental health policy, health care services policy, insurance policy, personal healthcare policy, pharmaceutical policy, policies related to public health such as vaccination policy, tobacco control policy or breastfeeding promotion policy, they may cover topics of financing and delivery of healthcare, access to care, quality of care, health equity. Health-related policy and its implementation is complex. Conceptual models can help show the flow from health-related policy development to health-related policy and program implementation and to health systems and health outcomes. Policy should be understood as more than a national law or health policy that supports a program or intervention.
Operational policies are the rules, regulations and administrative norms that governments use to translate national laws and policies into programs and services. The policy process encompasses decisions made at a national or decentralized level that affect whether and how services are delivered. Thus, attention must be paid to policies at multiple levels of the health system and over time to ensure sustainable scale-up. A supportive policy environment will facilitate the scale-up of health interventions. There are many topics in the politics and evidence that can influence the decision of a government, private sector business or other group to adopt a specific policy. Evidence-based policy relies on the use of science and rigorous studies such as randomized controlled trials to identify programs and practices capable of improving policy relevant outcomes. Most political debates surround personal health care policies those that seek to reform healthcare delivery, can be categorized as either philosophical or economic.
Philosophical debates center around questions about individual rights and government authority, while economic topics include how to maximize the efficiency of health care delivery and minimize costs. The modern concept of healthcare involves access to medical professionals from various fields as well as medical technology, such as medications and surgical equipment, it involves access to the latest information and evidence from research, including medical research and health services research. In many countries it is left to the individual to gain access to healthcare goods and services by paying for them directly as out-of-pocket expenses, to private sector players in the medical and pharmaceutical industries to develop research. Planning and production of health human resources is distributed among labour market participants. Other countries have an explicit policy to ensure and support access for all of its citizens, to fund health research, to plan for adequate numbers and quality of health workers to meet healthcare goals.
Many governments around the world have established universal health care, which takes the burden of healthcare expenses off of private businesses or individuals through pooling of financial risk. There are a variety of arguments against universal healthcare and related health policies. Healthcare is an important part of health systems and therefore it accounts for one of the largest areas of spending for both governments and individuals all over the world. Many countries and jurisdictions integrate a human rights philosophy in directing their healthcare policies; the World Health Organization reports that every country in the world is party to at least one human rights treaty that addresses health-related rights, including the right to health as well as other rights that relate to conditions necessary for good health. The United Nations' Universal Declaration of Human Rights asserts that medical care is a right of all people: UDHR Article 25: "Everyone has the right to a standard of living adequate for the health and well-being of himself and of his family, including food, clothing and medical care and necessary social services, the right to security in the event of unemployment, disability, old age or other lack of livelihood in circumstances beyond his control."In some jurisdictions and among different faith-based organizations, health policies are influenced by the perceived obligation shaped by religious beliefs to care for those in less favorable circumstances, including the sick.
Other jurisdictions and non-governmental organizations draw on the principles of humanism in defining their health policies, asserting the same perceived obligation and enshrined right to health. In recent years, the worldwide human rights organization Amnesty International has focused on health as a human right, addressing inadequate access to HIV drugs and women's sexual and reproductive rights including wide disparities in maternal mortality within and across countries; such increasing attention to health as a basic human right has been welcomed by the leading medical journal The Lancet. There remains considerable controversy regarding policies on who would be paying the costs of medical care for all people and under what circumstances. For example, government spending on healthcare is sometimes used as a global indicator of a government's commitment to the health of its people. On the other hand, one school of thought emerging from the United States rejects the notion of health care financing through taxpayer funding as incompatible with the