Acylglycerone-phosphate reductase

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acylglycerone-phosphate reductase
EC number1.1.1.101
CAS number37250-35-4
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, an acylglycerone-phosphate reductase (EC is an enzyme that catalyzes the chemical reaction

1-palmitoylglycerol 3-phosphate + NADP+ palmitoylglycerone phosphate + NADPH + H+

Thus, the two substrates of this enzyme are 1-palmitoylglycerol 3-phosphate and NADP+, whereas its 3 products are palmitoylglycerone phosphate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase. Other names in common use include palmitoyldihydroxyacetone-phosphate reductase, palmitoyl dihydroxyacetone phosphate reductase, palmitoyl-dihydroxyacetone-phosphate reductase, acyldihydroxyacetone phosphate reductase, and palmitoyl dihydroxyacetone phosphate reductase. This enzyme participates in glycerophospholipid and ether lipid metabolism.


  • LaBelle EF Jr; Hajra AK (1972). "Enzymatic reduction of alkyl and acyl derivatives of dihydroxyacetone phosphate by reduced pyridine nucleotides". J. Biol. Chem. 247 (18): 5825&ndash, 34. PMID 4403490.