Alkylglycerophosphoethanolamine phosphodiesterase

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alkylglycerophosphoethanolamine phosphodiesterase
Identifiers
EC number 3.1.4.39
CAS number 62213-15-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, an alkylglycerophosphoethanolamine phosphodiesterase (EC 3.1.4.39) is an enzyme that catalyzes the chemical reaction

1-alkyl-sn-glycero-3-phosphoethanolamine + H2O 1-alkyl-sn-glycerol 3-phosphate + ethanolamine

Thus, the two substrates of this enzyme are 1-alkyl-sn-glycero-3-phosphoethanolamine and H2O, whereas its two products are 1-alkyl-sn-glycerol 3-phosphate and ethanolamine.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds, the systematic name of this enzyme class is 1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase. This enzyme is also called lysophospholipase D, this enzyme participates in ether lipid metabolism.

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1FJ2.

References[edit]

  • Wykle RL, Schremmer JM (1974). "A lysophospholipase D pathway in the metabolism of ether-linked lipids in brain microsomes". J. Biol. Chem. 249 (6): 1742–6. PMID 4855486.