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Α-Methyltryptamine is a psychedelic and entactogen drug of the tryptamine class. It was developed as an antidepressant by workers at Upjohn in the 1960s, was used as an antidepressant in Russia under the trade name Indopan before being discontinued. ΑMT is tryptamine with a methyl substituent at the alpha carbon. This alpha substitution makes it a poor substrate for monoamine oxidase A, thereby prolonging αMT's half-life, allowing it to reach the brain and enter the central nervous system, its chemical relation to tryptamine is analogous to that of amphetamine to phenethylamine, amphetamine being α-methylphenethylamine. ΑMT is related to the neurotransmitter serotonin which explains its mechanism of action. The synthesis of αMT can be accomplished through several different routes, the two most known being the Nitroaldol Condensation between indole-3-carboxaldehyde and nitroethane under ammonium acetate catalysis and the condensation between indole-3-acetone and hydroxylamine followed by reduction of the obtained ketoxime with lithium aluminum hydride.

ΑMT acts as a balanced reuptake inhibitor and releasing agent of the main three monoamines. ΑMT has been shown as a reversible inhibitor of the enzyme monoamine oxidase in-vivo. In rats the potency of αMT as an MAO-A inhibitor in the brain was equal to that of harmaline at equimolar doses. Dexamphetamine did not enhance the 5-hydroxytryptophan-induced rise of serotonin at any level. A typical dose of harmaline for MAO inhibition is 150 mg, higher than any typical αMT dose so αMT's MAOI activity at typical doses will be significant but not total; the danger rises exponentially as αMT doses approach 150 mg due to increased monoamine release and increased MAO inhibition. 2-Oxo-αMT, 6-hydroxy-αMT, 7-hydroxy-αMT and 1′-hydroxy-αMT were detected as metabolites of αMT in male Wistar rats. Under the trade name Indopan, 5-10 milligrams were used for an antidepressant effect. With 20–30 milligrams, euphoria and psychedelic effects become apparent and can last as long as 12 hours. A dose exceeding 40 mg is considered strong.

In rare cases or extreme doses, the duration of effects might exceed 24 hours. Users report that αMT in freebase form is smoked, with doses between 5 milligrams. Reported side effects include anxiety, muscle tension, jaw tightness, pupil dilation, headaches and vomiting, among other effects that might be attributed to LSD, psilocybin, DMT, MDMA, such as open-eye visuals, closed eye visuals and an altered state of mind. In spite of some reported experiential similarities to MDMA, the chemicals are structurally unrelated. Like many other serotonin releasing agents, αMT's analog α-ethyltryptamine has been shown to produce long-lasting serotonergic neurotoxicity at high doses, it is possible. The 5-Methoxy analogue, 5-MeO-αMT is schedule 9 in Australia and αMT would be controlled as an analogue of this; as of October 2015 αMT is a controlled substance in China. In Denmark, the Danish Minister for the Interior and Health placed αMT to their lists of controlled substances. Canada has no mention of αMT in the Controlled Drugs and Substances Act.

ΑMT is listed under the Narcotics Act in schedule 1 in Germany. ΑMT is placed under Austrian law Group 6. ΑMT was controlled on the Schedule C list in Hungary in 2013. ΑMT was placed in 2013 on the List of Hazardous Substances in § 2 in Slovakia. ΑMT appeared on the Decree on Classification of Illicit Drugs in Slovenia. In Lithuania, αMT is controlled as a tryptamine derivative put under control in the 1st list of Narcotic Drugs and Psychotropic Substances which use is prohibited for medical purposes. ΑMT is legal in Spain. Sveriges riksdags health ministry Statens folkhälsoinstitut classified αMT as "health hazard" under the act Lagen om förbud mot vissa hälsofarliga varor as of Mar 1, 2005, in their regulation SFS 2005:26 listed as alfa-metyltryptamin, making it illegal to sell or possess. ΑMT was made illegal in the United Kingdom as of 7 January 2015, along with 5-MeO-DALT. This was following the events of 10 June 2014 when the Advisory Council on the Misuse of Drugs recommended that αMT be scheduled as a class A drug by updating the blanket ban clause on tryptamines.

The Drug Enforcement Administration placed αMT temporarily in schedule I of the Controlled Substances Act on April 4, 2003, pursuant to the temporary scheduling provisions of the CSA. On September 29, 2004, αMT was permanently controlled as a schedule I substance under the CSA. AMT, alfa-methyltryptamine is a controlled drug in Finland Deaths from αMT are rare but as a powerful monoamine releaser, injury can occur when excessive doses are taken or when taken with drugs such as MAOIs. Most fatalities are not verified but those which are involve excessive doses or coingestion with other drugs. A British teenager died after consuming 1 g of αMT in August 2013. TiHKAL entry αMT Entry in TiHKAL • info Erowid page on αMT Lycaeum page on αMT

Big Spring (Missouri)

Big Spring is one of the largest springs in the United States and the world. An enormous first magnitude spring, it rises at the base of a bluff on the west side of the Current River valley in the Missouri Ozarks. Located about four miles downstream from Van Buren, it is within the boundaries of the Ozark National Scenic Riverways, its visitor facilities are managed by the National Park Service, it is a contributing resource to Big Spring Historic District, listed on the National Register of Historic Places in 1981. The average flow of 470 cubic feet of water per second from Big Spring constitutes the second largest tributary of the Current River; the spring is by far the largest spring in the Ozark Plateau region. The only two springs in the Ozark region that approach the size of Big Spring are Greer Spring and Mammoth Spring. Maximum discharge of Big Spring must be estimated because backwater from the Current River makes accurate high water measurements impossible; the spring issues from the base of a limestone bluff, churning out aqua-blue water with great force, creating white caps quickly calming to a crystal clear channel.

The spring water travels about 1,000 feet. The water is about 58 degrees Fahrenheit, the spring is surrounded by a well maintained park and a steep valley hillside covered in hardwood forest. Most of the known drainage basin encompasses northern areas of the Eleven Point River watershed. Big Spring is increasing in size, as the groundwater continues to dissolve limestone in a vast karst system, continuation of stream capture in greater quantities; the spring is estimated to remove 175 tons of limestone during an average day. The amounts of limestone dissolved and removed by the spring system in one year is estimated to equal a one-mile long cave 30 feet high 50 feet wide, though that amount is dispersed among all parts of the karst system. List of Missouri rivers List of Arkansas rivers List of Ozark springs Karst spring Spring Ozark National Scenic Riverways

Joe Hill-Gibbins

Joe Hill-Gibbins is a British theatre and opera director. Hill-Gibbins was raised in Surrey, he attended a local comprehensive, George Abbot School, read Drama at Manchester University. Hill-Gibbins directed his first professional production, Wallace Shawn’s A Thought In Three Parts, at the Battersea Arts Centre as winner of the 2002 James Menzies-Kitchen Trust Award for young directors He trained at the Royal Court Theatre, both as an assistant director and script reader in the literary office. In 2004 he became Trainee Associate Director at the Royal Court, helping curate the Young Writer’s Festival for which he directed A Girl In A Car With A Man by Rob Evans. In 2006 Hill-Gibbins joined the staff of the Young Vic theatre. After directing Bertolt Brecht’s one-act comedy A Respectable Wedding in a new translation by Rory Bremner, he became an Associate Director. In 2010 he was appointed Deputy Artistic Director and directed acclaimed productions of Tennessee Williams' The Glass Menagerie and The Beauty Queen of Leenane by Martin McDonagh, which returned to the theatre in 2011.

In 2011 he directed Penelope Skinner's new play The Village Bike at the Royal Court. The Tragedy of King Richard the Second by William Shakespeare Edward II by Christopher Marlowe The Changeling by Thomas Middleton & William Rowley The Village Bike by Penelope Skinner The Glass Menagerie by Tennessee Williams The Beauty Queen of Leenane by Martin McDonagh The Girlfriend Experience by Alecky Blythe Bliss by Olivier Choinière, translated by Caryl Churchill Family Plays: The Good Family by Joakim Pirinen & The Khomenko Family Chronicles by Natalia Vorozhbit A Respectable Wedding by Bertolt Brecht, translated by Rory Bremner The Fever by Wallace Shawn A Girl In A Car With A Man by Rob Evans The One with the Oven by Emma Rosoman A Thought In Three Parts by Wallace Shawn

Joseph V. Melillo

Joseph V. Melillo was executive producer at the Brooklyn Academy of Music from 1999 to 2018, was named executive producer emeritus upon his departure, he is Columbia Artists' International Artistic Advisor, was a 2019 Director’s Fellow at the Center for Ballet and the Arts at New York University. Joseph V. Melillo earned a Bachelor of Arts degree in English and theater at Sacred Heart University in Fairfield, CT and a Masters of Fine Arts in speech and drama at Catholic University of America in Washington, DC. Melillo was responsible for the artistic direction of theater, music, visual art and more at the multi-venue arts center, which includes the Harvey Theater, Howard Gilman Opera House, Fishman Space, Rose Cinemas, BAMcafé. Prior to that, working with President/Executive Producer Harvey Lichtenstein, Melillo served as BAM’s producing director, following a six-year tenure as founding director of the BAM Next Wave Festival. Over 35 years at BAM, Melillo programmed the work of emerging and established artists such as Pina Bausch, Philip Glass, Trisha Brown, Bill T. Jones/Arnie Zane, Merce Cunningham, Robert Wilson, Urban Bush Women, Ivo van Hove, Ralph Lemon, Anne Bogart, Cheek by Jowl, Reggie Wilson, Mark Morris, Michelle Dorrance, among many others.

During his tenure, he worked alongside Karen Brooks Katy Clark. He forged artistic partnerships such as The Bridge Project—a three-year series of international theater engagements featuring a trans-Atlantic company of actors directed by Sam Mendes and produced by BAM, The Old Vic, Neal Street—and for seven seasons, DanceMotion USAsm, an international cultural diplomacy program in partnership with the US Department of State. In 1999, the BAM Rose Cinemas opened with four screens, including one dedicated to repertory and special series. Under Melillo’s guidance, in 2012—a year after celebrating 150 years—BAM expanded to include the Richard B. Fisher Building, it features the smaller, flexible Fishman Space, a third stage for BAM’s programs, as well as the Education department and childrens' programming. The history of Melillo’s programming at BAM is documented in two books: BAM: The Complete Works and BAM: The Next Wave Festival. BAM's extensive archive is publicly accessible through the Leon Levy Digital Archive.

Chevalier and Officier de L’ordre des Arts et des Lettres, France OBIE Award for International Programming Drama Desk Special Award for bringing works of distinction from around the world Honorary OBE for outstanding commitment to British performing arts in the US Knight of the Royal Order of the Polar Star for solidifying ties in performing arts between Sweden and the US Cultural ambassador for Taiwan for bringing the arts of Taiwan to US Honorary Doctorate of Humane Letters, St. Francis College, Brooklyn, NY Gaudium Award, Breukelein Institute National Medal of the Arts, received by Joseph V. Melillo and Karen B. Hopkins on behalf of BAM Knight of the National Order of Québec Bessie Awards, Presenter Award for Outstanding Curating Aga Khan Music Initiative, advisor Medal of Commander of the Ordre des Arts et des Lettres, France International Citation of Merit, International Society for the Performing Arts Melillo has served as an adjudicator/panelist for award-giving and honorary bodies including the Praemium Imperiale, Japan Art Association.

He has been on boards of directors. Https://

Winter Mountain

Winter Mountain is the stage name of singer-songwriter Joseph'Joe' Francis, based in Cornwall, UK. The brand of music is predominantly Indie Folk / Rock, he is becoming known for his songwriting abilities, high energy live soulful voice. A duo, Winter Mountain, toured the UK and Ireland extensively, becoming recognised for their close vocal harmonies and distinctive songwriting, they attracted the attention of many major record companies before signing to indie label'Charcoal Records' in 2011. In 2015, after releasing one album together, Smyth left Winter Mountain and Francis opted to keep the name for his solo work. In summer of 2016 Francis performed one of his first solo shows as Winter Mountain, opening for Seal; that same week, a solo Winter Mountain opened for The Feeling and the lead singer of Elbow, Guy Garvey. Winter Mountain released the self-produced'I Swear I Flew' on his'Astral Fox Records' label in November 2016. A song from the record,'The Lucky Ones', received radio play across the UK and Europe from multiple stations including BBC Radio 2.

Extensive grass roots touring followed the release, including a 2 week Spring Full Band Tour of the UK, Winter Mountains first with a backing group. Solo support sets for folk star and occasional Winter Mountain collaborator Seth Lakeman on his March'17 UK tour included performances at The Minack Theatre, The Hexagon and The Stables, Milton Keynes. In June 2017 Joe toured as support for Ben Ottewell, lead singer of British indie group Gomez on the Irish / UK leg of Ottewell's'A Man Apart' world tour. Hugely passionate about music from a young age, Francis got his first taste of songwriting and performing in local bars with school friends before going professional in his late teens; the signing of his first band to a London based Indie label led to Francis recording his debut album of original music at Abbey Road Studios, London. In 2008 Joe travelled to Memphis where he demoed some new material at Memphis. Francis and former member Martin Smyth met in 2009 while both were traveling by train to Memphis, Tennessee.

After the two performed and wrote together in Memphis, New York City, Francis visited Smyth at his home in Donegal and shortly afterwards formed Winter Mountain. They began touring after winning a ` battle of the bands' competition in Northern Ireland, their prize was two days at a local recording studio. They used the session to record what would become their debut EP, which featured five original songs. After a year of performing in pubs and folk clubs across the UK and Ireland, Winter Mountain were given the opportunity to accompany Northern Irish folk singer Cara Dillon at a theatre in Donegal, they presented their EP to Dillon's husband and manager Sam Lakeman and shortly afterwards, signed to Dillon and Lakemans fledgling label'Charcoal Records'. Their debut album'Winter Mountain', produced by Sam Lakeman and recorded at multiple vintage studios throughout the UK including Rockfields and State of the ark, was released in 2013 to much acclaim. Soon after the release Winter Mountain signed to Faber Music Publishing.

Smyth left Winter Mountain in 2015. In the year that followed Francis travelled The UK and France. Whilst on the road he wrote and demoed the songs that were to form Winter Mountains second album'I Swear I Flew'. Upon his return to Cornwall he began the process of recording the new songs at Cube Studios. During the recording process Francis set up his own'Astral Fox Records' and began planning the self-release of the album.'I Swear I Flew' was released to critical acclaim in November 2016. Winter Mountain has supported Seal, Ben Ottewell of Gomez, Guy Garvey of Elbow, The Feeling, Ocean Colour Scene, Leann Rhimes, Cara Dillon, Benny Gallagher, Seth Lakeman, Fleet Foxes, Paolo Nutini and Sean Watkins, Rosanne Cash, Richard Thompson, Grammy award winner Patty Griffin and others. Winter Mountain"I Swear I Flew"

The Most Assassinated Woman in the World

The Most Assassinated Woman in the World is a 2018 French mystery thriller and the debut feature film directed and produced by Franck Ribière. It stars Niels Schneider, Eric Godon, Sissi Duparc, André Wilms, Michel Fau; the leading lady of Grand Guignol Theatre in Paris, Paula Max, is known for being murdered in every show on stage. Someone starts to notice that there's a link between these murders and a series of murders in real-life; the film is the first Belgian movie made for Netflix. It was shot in a 1.85: 1 screen ratio through Spherical lens. It is loosely inspired by the life of actual French actress Paula Maxa. Filmed over the course of a month and a half on an estimated budget of €4,500,000, the film was released straight to Netflix after a premiere at the Brussels International Fantasy Film Festival in April 2018. In the early 1930s, Paula Maxa is one of the leading actresses at the Grand Guignol Theatre in Paris. Maxa is self-defined as the "most assassinated woman in the world" having become famous for being violently murdered on stage more than 10,000 times.

The theater director at the Grand Guignol is known for his gruesome stories and realistic gory special effects that leave audience members shocked and disgusted. Journalist "Jean" from Le Petit Journal is tasked with writing a critique of Maxa's performances, he seeks Maxa after her performance. On the way to her dressing room, he is given a bouquet of flowers by one of her costars to deliver to Maxa on behalf of one of her admirers; when he arrives in her dressing room, Maxa asks him to throw them away. The two are intrigued by one another, both noting they are not what either expected of a typical journalist or actress. After Maxa leaves for her next performance, Jean begins to look around her dressing room, notices the note attached to the flowers he brought her, which expresses her admirers love for her performances on stage, notably her deaths, how they cannot wait to murder her in real life. Jean reads that the note is from a J. After Jean leaves, an unknown man is seen entering Paula's dressing room, stealing the postcard on her mirror.

The next morning, Paula awakes with a scream from a nightmare in which a man wearing a mask and using a cane has followed her to a café and killed her. She has a vision of a girl in her bathtub, playing with dolls; the girl looks visibly deceased, with blue lips. Paula takes medication, the girl disappears. Jean is seen next at work with a stab wound on his hip; when a coworker tells Jean to have it checked by a doctor, Jean ignores him. He goes to see his boss. Although Jean wants to focus his story on the people of the theater, his boss reveals that he has been sent to investigate the link between numerous murders that have occurred in town and those portrayed on stage, he believes killers have been drawing inspiration from the fictitious murders for their real-life killings. That day, Jean goes to see Paula and asks her on a date. Paula arrives at work the next day and continues to have visions of the same girl from the bathtub, now on a beach, calling out to her by the name Marie-Therèse. Paula receives a package that night containing the new dress she is to wear for her performance, with a note that reads "This is the end, I am going to kill you one final time!" from the same sender.

Her date with Jean arrives and she is visibly distraught. At the same time, the unknown man from her dressing room is seen there again, this time smelling her perfume and trying on her wigs and makeup; the special effects director Paul asks him to leave. The man explains that he and Paul have a deal in which he delivers him dead bodies to use for the special effects in his plays, in return he is allowed to admire Paula, he explains that he has come to kill her. After their date and Jean go back to her apartment, she asks him how he got the wound on his hip, he explains that he was caught in an affair with a married woman, her husband delivered the stab wound to him when he caught them in the bathroom. Now that he has told her his secret, he asks her. Paula reveals that her sister Aimee ran away from home when she was younger to become an actress, they would meet in secret as to not alert their parents of her whereabouts, she tells him that during this time she began courting with a man named Jean, who had a limp and used a cane, due to a case of polio when he was younger.

One day, Jean offered to take her sister to the beach. When they arrived at the dunes, he became tried to rape Paula; as she tried to fight him, he beat her unconscious, with the last thing she remembers being him turning to rape her sister Aimee. When she awoke, Aimee's throat was slit and the man was gone. Paula reveals that she blames herself for not being able to save her sister or catch her killer, as she explains the man committed suicide before the police could arrest him, she tells Jean that she still hears the click of his cane when she is walking home at night, as though he is there. The two kiss and it is assumed. A woman named Violette is seen at a bar, flirting with the same man from Paula's dressing room, in hopes of having sex; the man accepts her advances and the two go back to his apartment. Once there, the man tries to kill her and Violette tries to escape; the man slices her throat and Violette dies. The special effects director, Paul, is seen the next morning reluctantly picking up Violette's body from the man.

At Le Petit Journal, Jean's coworker tells him t