Alternative-complement-pathway C3/C5 convertase

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Alternative-complement-pathway C3/C5 convertase
EC number
CAS number 80295-67-6
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Alternative-complement-pathway C3/C5 convertase (EC, complement component C3/C5 convertase (alternative), proenzyme factor B, properdin factor B, C3 proactivator, glycine-rich beta-glycoprotein, heat-labile factor, C3 convertase, C3b,Bb,CVF,Bb,C5 convertase, (C3b)n,Bb, complement C 3(C 5) convertase (amplification), alternative complement pathway C3(C5) convertase, C5 convertase, CVF,Bb, (CVF)-dependent glycine-rich-beta-glucoprotein, cobra venom factor-dependent C3 convertase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg- bond in complement component C5 alpha-chain to yield C5a and C5b

This enzyme is a bimolecular complex of complement fragment Bb with either C3b or cobra venom factor.

See also[edit]


  1. ^ Kerr, M.A. (1981). "Human factor B". Methods Enzymol. 80: 102–112. doi:10.1016/s0076-6879(81)80010-9. PMID 7043188. 
  2. ^ Morley, B.J.; Campbell, R.D. (1984). "Internal homologies of the Ba fragment from human complement component Factor B, as a class III MHC antigen". EMBO J. 3 (1): 153–157. PMC 557312Freely accessible. PMID 6323161. 
  3. ^ Müller-Eberhard, H.J. (1988). "Molecular organization and function of the complement system". Annu. Rev. Biochem. 57: 321–347. doi:10.1146/ PMID 3052276. 

External links[edit]