Aspartylglucosaminidase

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AGA
Protein AGA PDB 1apy.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAGA, Aga, AW060726, AGU, ASRG, GA, aspartylglucosaminidase
External IDsMGI: 104873 HomoloGene: 13 GeneCards: AGA
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for AGA
Genomic location for AGA
Band4q34.3Start177,430,770 bp[1]
End177,442,503 bp[1]
RNA expression pattern
PBB GE AGA 216064 s at fs.png

PBB GE AGA 204333 s at fs.png

PBB GE AGA 204332 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000027
NM_001171988

NM_001005847
NM_001205054

RefSeq (protein)

NP_000018
NP_001165459

NP_001005847
NP_001191983

Location (UCSC)Chr 4: 177.43 – 177.44 MbChr 8: 53.51 – 53.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase is an enzyme that in humans is encoded by the AGA gene.[5]

Aspartylglucosaminidase is an amidohydrolase enzyme involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme.[5]

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