Mississippi Highway 12 is a state highway in northern Mississippi that runs 198.7 miles (319.8 km) west–east from MS 1 west of Hollandale at the Mississippi River to State Route 18 at the Alabama state line northeast of Columbus. MS 12 traverses three major regions of the state, the Mississippi Delta, the North Central Hills, and the Golden Triangle.
Westbound on MS 12 bridge over the Sunflower River from Humphreys County, Mississippi