The Office is an American television sitcom broadcast on NBC. Created as an adaptation by Greg Daniels of the British series of the same name, it is a mockumentary that follows the day-to-day lives of the employees of the Scranton, Pennsylvania branch of Dunder Mifflin, a fictional paper supply company; the series ran on NBC in the United States from March 24, 2005 to May 16, 2013. Additionally, nine spin-off series of webisodes of The Office have been aired on NBC.com. The Office aired a short first season in 2005; this was followed by a full-length second season in 2005–06 that consisted of 22 episodes, a third season in 2006–07, with 25 episodes. Due to the 2007–2008 Writers Guild of America strike, the fourth season that aired in 2007–08 consisted of 19 episodes; the fifth season aired during 2008–09 and consisted of 28 episodes. The sixth season aired during 2009–10 and consisted of 26 episodes; the seventh season aired during 2010–11 and consisted of 26 episodes. The eighth season aired during 2011–12 and consisted of 24 episodes.
The ninth season aired during 2012–13 and consisted of 25 episodes. A total of 201 episodes of The Office aired over nine seasons; the first set of webisodes, titled The Accountants, consisted of ten episodes and ran between the second and third seasons. Kevin's Loan ran between the fourth and fifth seasons; the Outburst consisted of four episodes. Blackmail consisted of four episodes. Subtle Sexuality consisted of three episodes; the Mentor consisted of four episodes. The 3rd Floor consisted of three episodes; the Podcast consisted of three episodes. The latest webisode series, The Girl Next Door aired at the end of the seventh season and had two episodes. All nine seasons are available on DVD in regions 1, 2, 4. Starting with season five, the series is available on Blu-ray; this list is ordered by the episodes' original air dates and not by the production code numbers provided by NBC's official episode guide, which show the order in which episodes were filmed. Season one aired between March 24 and April 26, 2005.
It debuted as a midseason replacement for Committed. It carried over general plot ideas from the earlier British series created by Stephen Merchant and Ricky Gervais, the threat of wholesale downsizing. However, only the pilot was a direct adaptation of one of the UK version's episodes; this season introduced the main characters, established the general plot as a documentary crew is recording the lives of the employees of the fictitious Dunder Mifflin Paper Company. In a mockumentary format, it shows Michael Scott, regional manager of the Scranton branch office, as he tries to convince the filmmakers of the documentary that he presides over a happy, well-running office. Meanwhile, sales rep Jim Halpert finds methods to undermine Dwight Schrute. Season two of The Office premiered on September 20, 2005, ended on May 11, 2006. NBC ordered only six episodes for the season, in September, ordered seven more. On November 3, 2005, NBC ordered an additional three, in the end it had ordered a full season of 22 episodes.
Season two featured the first "super-sized" 40-minute episode of The Office. The second season further developed into the plot of the fear of company downsizing, along with the introduction of new characters and developing some of the minor ones—especially that of Dwight; as Michael starts a relationship with his boss Jan Levenson and Jim's relationship become one of the focal points of the season. Their compatibility becomes more obvious as Jim's feelings for Pam continue to grow, while she struggles with her relationship with the warehouse worker Roy Anderson. Season three premiered on September 21, 2006, ended on May 17, 2007, it featured 25 episodes, including two hour-long episodes, four "super-sized" episodes, guest directors such as J. J. Abrams, Joss Whedon and Harold Ramis; the season marked the move of main character Jim Halpert from Scranton to Stamford, introduced Rashida Jones as Karen Filippelli, Ed Helms as Andy Bernard as recurring characters. Helms would be promoted to series regular.
The main plot for the early episodes of the season deals with a recurring problem in seasons one and two—the problem of company downsizing—while in the latter half of the season, inter-office relationships became a major plot point. Metacritic, which assigns normalized ratings out of 100 to critics' reviews, calculated an average score of 85/100 based on five collected reviews, indicating "universal acclaim". NBC ordered a full fourth season of The Office consisting of 30 episodes, which included five one-hour specials. However, the 2007–2008 Writers Guild of America strike shut down production for nearly five months in the middle of the season; because of the shutdown, the fourth season of The Office only consisted of 19 half-hour episodes, ten of which were paired as five hour-long episodes. The season premiered on September 27, 2007. Season four marked the departure of Karen Filippelli as a regular character, although she appeared for a few seconds in th
Quincy Township is a township in Franklin County, United States. The population was 5,541 at the 2010 census, down from 5,846 at the 2000 census; the township has the name of 6th President of the United States. The township is in southeastern Franklin County, bordered to the east by Adams County; the borough of Mont Alto is surrounded by the northern part of the township but is a separate municipality. The western half of the township is part of the Great Appalachian Valley, an agricultural area with elevations in the township ranging from 650 to 1,100 feet, while the eastern half is on the slopes and crests of South Mountain, the highest point of, the summit of Snowy Mountain, with an elevation exceeding 2,080 feet; the Appalachian Trail traverses the eastern side of the township. Pennsylvania Route 997 crosses the center of the township, leading north through Mont Alto to Scotland, south to Waynesboro. Pennsylvania Route 316 passes through the western part of the township, leading north to Chambersburg, the county seat, south to Waynesboro.
Pennsylvania Route 233 runs east from Mont Alto through the northern part of the township, passing Mont Alto State Park and leading north into Guilford Township and to Caledonia State Park. The unincorporated community of Old Forge is in the southeastern part of the township, where the East Branch of Antietam Creek emerges from South Mountain. Other unincorporated communities include Quincy, which lies along PA 997 between Mont Alto and Waynesboro, South Mountain, in the northeast corner of the township and home of the South Mountain Restoration Center. According to the United States Census Bureau, the township has a total area of 45.2 square miles, of which 0.01 square miles, or 0.02%, is water. Antrim Township Guilford Township Hamiltonban Township, Washington Township As of the census of 2000, there were 5,846 people, 1,816 households, 1,416 families residing in the township; the population density was 130.9 people per square mile. There were 1,917 housing units at an average density of 42.9/sq mi.
The racial makeup of the township was 95.84% White, 2.22% African American, 0.12% Native American, 0.48% Asian, 0.02% Pacific Islander, 0.68% from other races, 0.63% from two or more races. Hispanic or Latino of any race were 1.18% of the population. There were 1,816 households, out of which 30.8% had children under the age of 18 living with them, 66.7% were married couples living together, 6.9% had a female householder with no husband present, 22.0% were non-families. 18.9% of all households were made up of individuals, 10.8% had someone living alone, 65 years of age or older. The average household size was 2.67 and the average family size was 3.02. In the township the population was spread out, with 23.3% under the age of 18, 13.9% from 18 to 24, 22.9% from 25 to 44, 20.4% from 45 to 64, 19.6% who were 65 years of age or older. The median age was 37 years. For every 100 females, there were 100.1 males. For every 100 females age 18 and over, there were 90.9 males. The median income for a household in the township was $41,214, the median income for a family was $47,350.
Males had a median income of $30,451 versus $23,663 for females. The per capita income for the township was $16,816. About 4.2% of families and 8.5% of the population were below the poverty line, including 13.1% of those under age 18 and 10.3% of those age 65 or over. Quincy Township official website
Zimmermann is a luxury Australian brand of fashion. Zimmermann was founded in 1991 by Simone Zimmermann. Sisters Nicky and Simone Zimmermann founded the label in 1991, while the first store was opened in 1992, it all started in Sydney, when Nicky Zimmermann, who attended the design school in East Sydney, began designing garments from her parent’s garage and selling them at Paddington markets where she could see first-hand how women responded to her clothing. Her sister Simone joined her in 1991. Zimmermann presents their ready-to-wear collections each year in both Australia and the USA at New York Fashion Week. In the following years, the Zimmermann label extended to Swim Separates and Accessories. After the expansion, Zimmermann started making ready-to-wear collections available outside of Australia. In 2008 Zimmermann launched its online boutique at zimmermannwear.com. Since the launching in the USA in 2011, Zimmermann has followed a Northern Hemisphere calendar for collection release; this includes Spring/Summer and Resort collections for Ready to Wear, Summer and Resort for Swim.
The Zimmermann brand now includes the lines Ready-to-Wear and Resort, Accessories. The Zimmermann label has received acclaim from household names such as Beyoncé, Kendall Jenner and Bella Hadid, Margot Robbie, Chrissy Teigen, Karlie Kloss, Jessica Alba, Kate Hudson, Paris Jackson, Jessica Biel, all who have been sighted in Zimmermann designs; the brand received the Australian Fashion Laureate Award in 2014, AFI Best Swimwear Designer, Prix de Marie Claire Best Swimwear Brand, Prix de Marie Claire Best Swimwear Designer. Nicky Zimmermann has been a member of the Australian Fashion Week Advisory Board and has been a mentor for the QANTAS Spirit of Australia Youth Awards. Nicky was a founding board member of the Australian Fashion Chamber. Zimmermann has 27 stores located throughout Australia, the USA, the UK; the collections are stocked in stores internationally, including Barney’s, Saks 5th Avenue, Bergdorf Goodman, Selfridges and Harvey Nichols. Zimmermann is featured on Net-A- Porter. Zimmermann maintains showrooms in Sydney, France, New York, Los Angeles
Oxygen is the chemical element with the symbol O and atomic number 8. It is a member of the chalcogen group in the periodic table, a reactive nonmetal, an oxidizing agent that forms oxides with most elements as well as with other compounds. By mass, oxygen is the third-most abundant element in the universe, after helium. At standard temperature and pressure, two atoms of the element bind to form dioxygen, a colorless and odorless diatomic gas with the formula O2. Diatomic oxygen gas constitutes 20.8% of the Earth's atmosphere. As compounds including oxides, the element makes up half of the Earth's crust. Dioxygen is used in cellular respiration and many major classes of organic molecules in living organisms contain oxygen, such as proteins, nucleic acids and fats, as do the major constituent inorganic compounds of animal shells and bone. Most of the mass of living organisms is oxygen as a component of water, the major constituent of lifeforms. Oxygen is continuously replenished in Earth's atmosphere by photosynthesis, which uses the energy of sunlight to produce oxygen from water and carbon dioxide.
Oxygen is too chemically reactive to remain a free element in air without being continuously replenished by the photosynthetic action of living organisms. Another form of oxygen, ozone absorbs ultraviolet UVB radiation and the high-altitude ozone layer helps protect the biosphere from ultraviolet radiation. However, ozone present at the surface is a byproduct of thus a pollutant. Oxygen was isolated by Michael Sendivogius before 1604, but it is believed that the element was discovered independently by Carl Wilhelm Scheele, in Uppsala, in 1773 or earlier, Joseph Priestley in Wiltshire, in 1774. Priority is given for Priestley because his work was published first. Priestley, called oxygen "dephlogisticated air", did not recognize it as a chemical element; the name oxygen was coined in 1777 by Antoine Lavoisier, who first recognized oxygen as a chemical element and characterized the role it plays in combustion. Common uses of oxygen include production of steel and textiles, brazing and cutting of steels and other metals, rocket propellant, oxygen therapy, life support systems in aircraft, submarines and diving.
One of the first known experiments on the relationship between combustion and air was conducted by the 2nd century BCE Greek writer on mechanics, Philo of Byzantium. In his work Pneumatica, Philo observed that inverting a vessel over a burning candle and surrounding the vessel's neck with water resulted in some water rising into the neck. Philo incorrectly surmised that parts of the air in the vessel were converted into the classical element fire and thus were able to escape through pores in the glass. Many centuries Leonardo da Vinci built on Philo's work by observing that a portion of air is consumed during combustion and respiration. In the late 17th century, Robert Boyle proved. English chemist John Mayow refined this work by showing that fire requires only a part of air that he called spiritus nitroaereus. In one experiment, he found that placing either a mouse or a lit candle in a closed container over water caused the water to rise and replace one-fourteenth of the air's volume before extinguishing the subjects.
From this he surmised that nitroaereus is consumed in both combustion. Mayow observed that antimony increased in weight when heated, inferred that the nitroaereus must have combined with it, he thought that the lungs separate nitroaereus from air and pass it into the blood and that animal heat and muscle movement result from the reaction of nitroaereus with certain substances in the body. Accounts of these and other experiments and ideas were published in 1668 in his work Tractatus duo in the tract "De respiratione". Robert Hooke, Ole Borch, Mikhail Lomonosov, Pierre Bayen all produced oxygen in experiments in the 17th and the 18th century but none of them recognized it as a chemical element; this may have been in part due to the prevalence of the philosophy of combustion and corrosion called the phlogiston theory, the favored explanation of those processes. Established in 1667 by the German alchemist J. J. Becher, modified by the chemist Georg Ernst Stahl by 1731, phlogiston theory stated that all combustible materials were made of two parts.
One part, called phlogiston, was given off when the substance containing it was burned, while the dephlogisticated part was thought to be its true form, or calx. Combustible materials that leave little residue, such as wood or coal, were thought to be made of phlogiston. Air did not play a role in phlogiston theory, nor were any initial quantitative experiments conducted to test the idea. Polish alchemist and physician Michael Sendivogius in his work De Lapide Philosophorum Tractatus duodecim e naturae fonte et manuali experientia depromti described a substance contained in air, referring to it as'cibus vitae', this substance is identical with oxygen. Sendivogius, during his experiments performed between 1598 and 1604, properly recognized that the substance is equivalent to the gaseous byproduct released by the thermal decomposition of potassium nitrate. In Bugaj's view, the isolation of oxygen and the proper association of the substance to that part of air, required for life, lends sufficient weight to the discovery of oxygen by Sendivogius
MiR-296 is a family of microRNA precursors found in mammals, including humans. The ~ 22 nucleotide mature; this sequence associates with RISC which effects RNA interference.miR-296 has been named an "angiomiR" due to being characterised as a microRNA which regulates angiogenesis, the process of growth and creation of new blood vessels. MiR-296 is thought to have a specific role in cancer in promoting tumour angiogenesis, it achieves this by targeting HGS mRNA, reducing its expression in endothelial cells which results in greater number of VEGF receptors.miR-296 has predicted target sites in the transcription factor NANOG and may contribute to carcinogenesis by dysregulating p53. Page for microRNA mir-296 at Rfam