The Autostrada A29 is a 114.8 km (71.3 mi) motorway on the island of Sicily that links Palermo to Mazara del Vallo. The motorway is also called Autostrada del Sale because one of its branches ends at the Salt Pans between Marsala and Trapani. It's a four-lane motorway in its whole length.

Mazara del Vallo is a town and comune in the province of Trapani, southwestern Sicily, Italy. It lies mainly on the left bank at the mouth of the Mazaro river.