Osmotic-controlled release oral delivery system

The osmotic-controlled release oral delivery system is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, the resulting osmotic pressure is used to push the active drug through the opening in the gastrointestinal tract. OROS is a trademarked name owned by ALZA Corporation, which pioneered the use of osmotic pumps for oral drug delivery. Osmotic release systems have a number of major advantages over other controlled-release mechanisms, they are less affected by factors such as pH, food intake, GI motility, differing intestinal environments. Using an osmotic pump to deliver drugs has additional inherent advantages regarding control over drug delivery rates; this allows for much more precise drug delivery over an extended period of time, which results in much more predictable pharmacokinetics.

However, osmotic release systems are complicated, somewhat difficult to manufacture, may cause irritation or blockage of the GI tract due to prolonged release of irritating drugs from the non-deformable tablet. The Elementary Osmotic Pump was developed by ALZA in 1974, was the first practical example of an osmotic pump based drug release system for oral use, it was introduced to the market in the early 1980s in Osmosin and Acutrim, but unexpectedly severe issues with GI irritation and cases of GI perforation led to the withdrawal of Osmosin. Merck & Co. developed the Controlled-Porosity Osmotic Pump with the intention of addressing some of the issues that led to Osmosin's withdrawal via a new approach to the final stage of the release mechanism. Unlike the EOP, the CPOP had no pre-formed hole in the outer shell for the drug to be expelled out of. Instead, the CPOP's semipermeable membrane was designed to form numerous small pores upon contact with water through which the drug would be expelled via osmotic pressure.

The pores were formed via the use of a pH insensitive leachable or dissolvable additive such as sorbitol. Both the EOP and CPOP were simple designs, were limited by their inability to deliver poorly soluble drugs; this led to the development of an additional internal "push layer" composed of material that would expand as it absorbed water, which pushed the drug layer out of the exit hole at a controlled rate. Osmotic agents such as sodium chloride, potassium chloride, or xylitol are added to both the drug and push layers to increase the osmotic pressure; the initial design developed in 1982 by ALZA researchers was designated the Push-Pull Osmotic Pump, Procardia XL was one of the first drugs to utilize this PPOP design. In the early 1990s, an ALZA-funded research program began to develop a new dosage form of methylphenidate for the treatment of children with attention deficit hyperactivity disorder. Methylphenidate's short half-life required multiple doses to be administered each day to attain long-lasting coverage, which made it an ideal candidate for the OROS technology.

Multiple candidate pharmacokinetic profiles were evaluated and tested in an attempt to determine the optimal way to deliver the drug, important given the puzzling failure of an existing extended-release formulation of methylphenidate to act as expected. The zero-order release profile that the PPOP was optimal at delivering failed to maintain its efficacy over time, which suggested that acute tolerance to methylphenidate formed over the course of the day; this explained why Ritalin SR was inferior to twice-daily Ritalin IR, led to the hypothesis that an ascending pattern of drug delivery was necessary to maintain clinical effect. Trials designed to test this hypothesis were successful, ALZA subsequently developed a modified PPOP design that utilized an overcoat of methylphenidate designed to release and raise serum levels, followed by 10 hours of first-order drug delivery from the modified PPOP design; this design was called the Push-Stick Osmotic Pump, utilized two separate drug layers with different concentrations of methylphenidate in addition to the push layer.

OROS medications include

HMS Prince of Wales (1794)

HMS Prince of Wales was a 98-gun second rate ship of the line of the Royal Navy, launched on 28 June 1794 at Portsmouth. In the spring of 1795, she served as the flagship of Admiral Henry Harvey who commanded a squadron in the North Sea and participated in the Battle of Groix in 1795. Prince of Wales served as the flagship of Admiral Robert Calder at the Battle of Cape Finisterre in 1805, she was not present at Trafalgar. In consequence of the strong feeling against him for his conduct at Cape Finisterre, Calder had demanded a court-martial. Nelson was ordered to send Calder home, allowed him to return in his own flagship though battle was imminent. Calder left in early October 1805. Prince of Wales was broken up in December 1822. Media related to HMS Prince of Wales at Wikimedia Commons