Benzoin aldolase

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benzoin aldolase
EC number4.1.2.38
CAS number122097-01-2
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a benzoin aldolase (EC is an enzyme that catalyzes the chemical reaction

benzoin 2 benzaldehyde

Hence, this enzyme has one substrate, benzoin, and one product, benzaldehyde.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase (benzaldehyde-forming)—the systematic name of benzoin is 2-hydroxy-1,2-diphenylethanone. Other names in common use include benzaldehyde lyase, and 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase. It employs one cofactor, thiamin diphosphate.

Structural studies[edit]

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2AG0, 2AG1, and 2UZ1.


  • Gonzalez B, Vicuna R (1989). "Benzaldehyde lyase, a novel thiamine PPi-requiring enzyme, from Pseudomonas fluorescens biovar I". J. Bacteriol. 171 (5): 2401&ndash, 5. PMC 209914. PMID 2496105.