Beta-cubebene synthase

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Beta-cubebene synthase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Beta-cubebene synthase (EC, cop4, Mg25) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, beta-cubebene-forming).[1][2][3][4] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate beta-cubebene + diphosphate

Isolated from the fungus Coprinus cinereus.


  1. ^ Lee, S.; Chappell, J. (2008). "Biochemical and genomic characterization of terpene synthases in Magnolia grandiflora". Plant Physiol. 147: 1017–1033. doi:10.1104/pp.108.115824. PMC 2442544Freely accessible. PMID 18467455. 
  2. ^ Agger, S.; Lopez-Gallego, F.; Schmidt-Dannert, C. (2009). "Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus". Mol. Microbiol. 72: 1181–1195. doi:10.1111/j.1365-2958.2009.06717.x. PMC 2723806Freely accessible. PMID 19400802. 
  3. ^ Lopez-Gallego, F.; Agger, S.A.; Abate-Pella, D.; Distefano, M.D.; Schmidt-Dannert, C. (2010). "Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers". Chembiochem. 11: 1093–1106. doi:10.1002/cbic.200900671. PMC 2873112Freely accessible. PMID 20419721. 
  4. ^ Lopez-Gallego, F.; Wawrzyn, G.T.; Schmidt-Dannert, C. (2010). "Selectivity of fungal sesquiterpene synthases: role of the active site’s H-1α loop in catalysis". Appl. Environ. Microbiol. 76: 7723–7733. doi:10.1128/aem.01811-10. PMC 2988597Freely accessible. PMID 20889795. 

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