Bowdoin Square in Boston, Massachusetts was located in the West End. In the 18th and 19th centuries it featured residential houses, leafy trees, a church, hotel, theatre and other buildings. Among the notables who have lived in the square: physician Thomas Bulfinch; merchant Kirk Boott; and mayor Theodore Lyman. The urban renewal project in the West End in the 1950s removed Green Street and Chardon Street, which formerly ran into the square, and renamed some existing streets; it is now a traffic intersection at Cambridge Street, Bowdoin Street, and New Chardon Street.

George Parkman, a Boston Brahmin and a member of one of Boston's richest families, was a prominent physician, businessman, and philanthropist, as well the victim in the sensationally gruesome Parkman–Webster murder case, which shook Boston in 1849–1850.