The CMLL Universal Championship 2010 was a professional wrestling annual tournament produced by Consejo Mundial de Lucha Libre (CMLL) took take place over three CMLL Super Viernes shows between July 30, 2010 and August 13, 2010 in Arena México, Mexico City, Mexico. The CMLL Universal Championship is an annual tournament of CMLL Champions that was first held in 2009. All officially recognized male CMLL Champions participated in a 16-man tournament. In the finals CMLL World Middleweight Champion Jushin Thunder Liger defeated CMLL World Trios Champion La Sombra to win the tournament.

The CMLL Universal Championship is an annual lucha libre tournament held by the Mexican professional wrestling promotion Consejo Mundial de Lucha Libre (CMLL) since 2009. The tournament format is a "tournament of champions" with sixteen male CMLL champions participating. With the 2019 tournament CMLL has held nine tournaments in total with only two repeat winners, Último Guerrero who won in both 2009 and 2014 and El Terrible who won in 2012 and 2019.