From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Calicivirin (EC, Camberwell virus processing peptidase, Chiba virus processing peptidase, Norwalk virus processing peptidase, Southampton virus processing peptidase, norovirus virus processing peptidase, calicivirus trypsin-like cysteine protease, calicivirus TCP, calicivirus 3C-like protease, calicivirus endopeptidase, rabbit hemorrhagic disease virus 3C endopeptidase) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

Endopeptidase with a preference for cleavage when the P1 position is occupied by Glu- and the P1- position is occupied by Gly-

Viruses that are members of the genus Norovirus (family Caliciviridae) are a major cause of epidemic acute viral gastroenteritis.


  1. ^ Meyers, G.; Rossi, C.; Thiel, H.J. (2004). "Calicivirus endopeptidases". In Barrett, A.J.; Rawlings, N.D.; Woessner, J.F. Handbook of Proteolytic Enzymes (2nd ed.). London: Elsevier. pp. 1380–1382. 
  2. ^ Wirblich, C.; Sibilia, M.; Boniotti, M.B.; Rossi, C.; Thiel, H.J.; Meyers, G. (1995). "3C-like protease of rabbit hemorrhagic disease virus: identification of cleavage sites in the ORF1 polyprotein and analysis of cleavage specificity". J. Virol. 69: 7159–7168. PMC 189637Freely accessible. PMID 7474137. 
  3. ^ Martin Alonso, J.M.; Casais, R.; Boga, J.A.; Parra, F. (1996). "Processing of rabbit hemorrhagic disease virus polyprotein". J. Virol. 70: 1261–1265. PMC 189940Freely accessible. PMID 8551592. 
  4. ^ Liu, B.; Clarke, I.N.; Lambden, P.R. (1996). "Polyprotein processing in Southampton virus: identification of 3C-like protease cleavage sites by in vitro mutagenesis". J. Virol. 70: 2605–2610. PMC 190109Freely accessible. PMID 8642693. 
  5. ^ Liu, B.L.; Viljoen, G.J.; Clarke, I.N.; Lambden, P.R. (1999). "Identification of further proteolytic cleavage sites in the Southampton calicivirus polyprotein by expression of the viral protease in E. coli". J. Gen. Virol. 80: 291–296. doi:10.1099/0022-1317-80-2-291. PMID 10073687. 

External links[edit]