Carbondale is a city in Jackson County, Illinois, United States, within the Southern Illinois region informally known as "Little Egypt". As of the 2020 census, the city had a population of 25,083, making it the most populous city in Southern Illinois outside the Metro East region of Greater St. Louis.

Jackson County is a county located in the U.S. state of Illinois with a population of 52,974 at the 2020 census. Its county seat is Murphysboro, and its most populous city is Carbondale, home to the main campus of Southern Illinois University. The county was incorporated on January 10, 1816, and named for Andrew Jackson. The community of Brownsville served as the fledgling county's first seat.