Ceramide glucosyltransferase

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Ceramide glucosyltransferase
Identifiers
EC number 2.4.1.80
CAS number 37237-44-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Ceramide glucosyltransferase (or glucosylceramide synthase) is a glucosyltransferase enzyme involved in the production of glucocerebroside.[1]

It is classified under EC 2.4.1.80.

It is inhibited by miglustat and eliglustat, both drugs developed for the treatment of Gaucher disease.

See also[edit]

References[edit]

  1. ^ Ichikawa S, Sakiyama H, Suzuki G, Hidari KI, Hirabayashi Y (May 1996). "Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 4638–43. doi:10.1073/pnas.93.10.4638. PMC 39331Freely accessible. PMID 8643456. 

External links[edit]