ChEMBL or ChEMBLdb is a manually curated chemical database of bioactive molecules with drug-like properties. It is maintained by the European Bioinformatics Institute, of the European Molecular Biology Laboratory, based at the Wellcome Trust Genome Campus, Hinxton, UK; the database known as StARlite, was developed by a biotechnology company called Inpharmatica Ltd. acquired by Galapagos NV. The data was acquired for EMBL in 2008 with an award from The Wellcome Trust, resulting in the creation of the ChEMBL chemogenomics group at EMBL-EBI, led by John Overington; the ChEMBL database contains compound bioactivity data against drug targets. Bioactivity is reported in Ki, Kd, IC50, EC50. Data can be filtered and analyzed to develop compound screening libraries for lead identification during drug discovery. ChEMBL version 2 was launched in January 2010, including 2.4 million bioassay measurements covering 622,824 compounds, including 24,000 natural products. This was obtained from curating over 34,000 publications across twelve medicinal chemistry journals.
ChEMBL's coverage of available bioactivity data has grown to become "the most comprehensive seen in a public database.". In October 2010 ChEMBL version 8 was launched, with over 2.97 million bioassay measurements covering 636,269 compounds. ChEMBL_10 saw the addition of the PubChem confirmatory assays, in order to integrate data, comparable to the type and class of data contained within ChEMBL. ChEMBLdb can be downloaded by File Transfer Protocol, it is formatted in a manner amenable to computerized data mining, attempts to standardize activities between different publications, to enable comparative analysis. ChEMBL is integrated into other large-scale chemistry resources, including PubChem and the ChemSpider system of the Royal Society of Chemistry. In addition to the database, the ChEMBL group have developed resources for data mining; these include an integrated chemogenomics workbench focussed on kinases. The system incorporates and links sequence, structure and screening data. GPCR SARfari is a similar workbench focused on GPCRs, ChEMBL-Neglected Tropical Diseases is a repository for Open Access primary screening and medicinal chemistry data directed at endemic tropical diseases of the developing regions of the Africa and the Americas.
The primary purpose of ChEMBL-NTD is to provide a accessible and permanent archive and distribution centre for deposited data. July 2012 saw the release of a new malaria data service, sponsored by the Medicines for Malaria Venture, aimed at researchers around the globe; the data in this service includes compounds from the Malaria Box screening set, as well as the other donated malaria data found in ChEMBL-NTD. MyChEMBL, the ChEMBL virtual machine, was released in October 2013 to allow users to access a complete and free, easy-to-install cheminformatics infrastructure. In December 2013, the operations of the SureChem patent informatics database were transferred to EMBL-EBI. In a portmanteau, SureChem was renamed SureChEMBL. 2014 saw the introduction of the new resource ADME SARfari - a tool for predicting and comparing cross-species ADME targets. ChEMBL: Quick Tour on EBI Train OnLine ChEBI DrugBank ChEMBLdb Kinase SARfari ChEMBL-Neglected Tropical Disease Archive GPCR SARfari The ChEMBL-og Open data and drug discovery blog run by the ChEMBL team
The University of California Davis School of Law, referred to as UC Davis School of Law and known as King Hall and UC Davis Law, is an American Bar Association approved law school located in Davis, California on the campus of the University of California, Davis. The school received ABA approval in 1968, it joined the Association of American Law Schools in 1968. UC Davis School of Law is the smallest of the five law schools in the University of California system, with a total enrollment of just under 600 students; the school is located in a building named for Dr. Martin Luther King Jr. and referred to as King Hall. In 2016, US News & World Report ranked UC Davis 30th among top law schools in the U. S. and as the second-most diverse of the five law schools in the UC system. Princeton Review placed UC Davis tenth in the nation in the 2009 version of its annual ranking of faculty diversity among American law schools, it is listed as an "A-" in the March 2011 "Diversity Honor Roll" by The National Jurist: The Magazine for Law Students.
It is listed as an "A" in the January 2011 "Best Public Interest Law Schools" ratings by The National Jurist: The Magazine for Law Students. UC Davis Law has the smallest student body of the UC schools, but a higher student/faculty ratio than UCLA or Berkeley. UC Davis has been ranked as the fifth most-expensive public law school in the nation by U. S. News & World Report, it is ranked first for providing the most financial aid. UC Davis grants the second-most in financial aid in the country. UC Davis Law's King Hall Loan Repayment Assistance Program, founded in 1990 to help alumni working in low-income public-service law careers to repay student loans, was the first loan repayment assistance program established at any UC law school. According to Brian Leiter's Law School rankings, Davis ranks 23rd in the nation in terms of scholarly impact as measured by academic citations of tenure-stream faculty. Based on a 2001-2007 6 year average, 79.4% of UC Davis Law graduates passed the California State Bar exam.
In 2009, 89% of first-time test takers passed the California bar. For July 2012, 78.9% of first-time test takers passed the California bar exam. For July 2013, 85.0% of first-time test takers passed the California Bar Exam. For July 2014, 86% of first-time test takers passed the California bar exam. According to King Hall's official 2017 ABA-required disclosures, 79% of the Class of 2017 obtained full-time, long-term, JD-required employment nine months after graduation. King Hall's Law School Transparency under-employment score is 10.2%, indicating the percentage of the Class of 2017 unemployed, pursuing an additional degree, or working in a non-professional, short-term, or part-time job nine months after graduation. The total cost of attendance at King Hall for the 2013-2014 academic year is $68,346 for California residents and $80,591 for non-residents; the Law School Transparency estimated debt-financed cost of attendance for three years is $265,806 for residents. The law school completed a $30 million expansion project in 2011.
The project has added an additional wing to the law school's current building, increasing assignable space by nearly 30 percent to provide for additional classrooms, a new courtroom, named the Paul and Lydia Kalmanovitz Appellate Courtroom in honor of a $1 million gift to the project from the Kalmanovitz Charitable Foundation. The courtroom is used by the U. S. Court of Appeals for the Ninth Circuit, California Supreme Court, California Court of Appeal. Alan Brownstein and Bird Chair for the Study and Teaching of Freedom and Equality Gabriel "Jack" Chin, Professor of Law, specialist in fields of immigration law and criminal procedure Joel Dobris, Professor of Law, scholar of Trusts and Estates Angela P. Harris, Professor of Law, critical legal theory scholar Robert W. Hillman, Professor of Law, Fair Business Practices and Investor Advocacy Chair Edward Imwinkelried, Edward L. Barrett Jr. Professor of Law Kevin Johnson and Mabie-Apallas Professor of Public Interest Law and Chicana/o Studies, specialist in civil rights and Chicano/a rights law Miguel Méndez, Professor of Law, evidence law scholar Terry O'Neill, National Organization for Women, acting professor of law 1988-1989.
Rex R. Perschbacher, Daniel J. Dykstra Endowed Chair, former Dean of the Law School, 1998-2008 Cruz Reynoso, Associate Justice of the California Supreme Court 1982-1987, Professor Emeritus Martha West, former Associate Dean, he serves as Co-Reporter for the American Law Institute's Restatement of Foreign Relations Law: Jurisdiction and as a member of the State Department's Advisory Committee on International Law. Tani Cantil-Sakauye, the 28th and current Chief Justice of the California Supreme Court Craig F. Stowers, Associate Justice of the Alaska Supreme Court Kristina Pickering, Associate Justice of the Supreme Court of Nevada Clint Bolick, Associate Justice of the Supreme Court of Arizona F. Philip Carbullido, Associate Justice of the Supreme Court of Guam. S. Department of Labor Administrative Review Board.
Castle Mountain is a ski resort located in the Westcastle Valley of southwest Alberta, Canada in the Rocky Mountains. It is 270 kilometres from Calgary and the Calgary International Airport; the resort is renowned for an average 9 metres of snowfall yearly. Despite the name, Castle Mountain Resort is not on Castle Mountain, about 240 kilometres away within Banff National Park; the name is derived from the Castle Rivers, the nearby Windsor Mountain. Windsor Mountain was named by the Blakiston group of the Palliser Expedition as Castle Mountain, within days of the naming of the Banff peak by the Palliser group of the Palliser Expedition; the name was changed to Windsor Mountain due to its shape and visible'towers', which are still named as the Castle Peaks, which resemble Windsor Castle. The resort maintains 78 ski trails including 8 alpine bowls, with 15% beginner, 40% intermediate, 35% advanced, 10% expert terrain. Six lift systems with vertical rises from 445 to 50 m with the highest vertical being 863 m, are operated on the slopes of Mount Haig and Gravenstafel Ridge.
Castle Mountain Resort was opened in 1965. It was the site of the 1975 Canada Winter Games. Castle Mountain Resort Website