Charcot–Marie–Tooth disease is one of the hereditary motor and sensory neuropathies of the peripheral nervous system characterized by progressive loss of muscle tissue and touch sensation across various parts of the body. Incurable, this disease is the most inherited neurological disorder, affects about one in 2,500 people. CMT was classified as a subtype of muscular dystrophy. Symptoms of CMT begin in early childhood or early adulthood, but can begin later; some people do not experience symptoms until their early 40s. The initial symptom is foot drop early in the course of the disease; this can cause hammer toe, where the toes are always curled. Wasting of muscle tissue of the lower parts of the legs may give rise to a "stork leg" or "inverted champagne bottle" appearance. Weakness in the hands and forearms occurs in many people. Loss of touch sensation in the feet and legs, as well as in the hands and arms occurs with various types of the disease. Early- and late-onset forms occur with'on and off' painful spasmodic muscular contractions that can be disabling when the disease activates.
High-arched feet or flat-arched feet are classically associated with the disorder. Sensory and proprioceptive nerves in the hands and feet are damaged, while unmyelinated pain nerves are left intact. Overuse of an affected hand or limb can activate symptoms including numbness and painful cramping. Symptoms and progression of the disease can vary. Involuntary grinding of teeth and squinting are prevalent, go unnoticed by the person affected. Breathing can be affected in some, as can hearing and neck and shoulder muscles. Scoliosis is common, causing hunching and loss of height. Hip sockets can be malformed. Gastrointestinal problems can be part of CMT, as can difficulty chewing and speaking. A tremor can develop as muscles waste. Pregnancy has been known to exacerbate CMT, as well as severe emotional stress. Patients with CMT must avoid periods of prolonged immobility such as when recovering from a secondary injury, as prolonged periods of limited mobility can drastically accelerate symptoms of CMT.
Pain due to postural changes, skeletal deformations, muscle fatigue, cramping is common in people with CMT. It can be mitigated or treated by physical therapies and corrective or assistive devices. Analgesic medications may be needed if other therapies do not provide relief from pain. Neuropathic pain is a symptom of CMT, like other symptoms of CMT, its presence and severity vary from case to case. For some people, pain can interfere with daily life activities. However, pain is not experienced by all people with CMT; when neuropathic pain is present as a symptom of CMT, it is comparable to that seen in other peripheral neuropathies, as well as postherpetic neuralgia and complex regional pain syndrome, among other diseases. Charcot -- Marie -- Tooth. Nerve signals are conducted by an axon with a myelin sheath wrapped around it. Most mutations in CMT affect the myelin sheath. CMT is a heterogeneous disease and the mutations linked to it may occur in a number of different genes. Based on the affected gene, CMT is categorized into several subtypes.
The most common cause of CMT is the duplication of a large region on the short arm of chromosome 17 that includes the gene PMP22. Some mutations affect the gene MFN2, on chromosome 1. Mutated MFN2 causes the mitochondria to form large clusters, or clots, which are unable to travel down the axon towards the synapses; this prevents the synapses from functioning. CMT can be produced by X-linked mutations, is named X-linked CMT. In CMTX, mutated connexons create non-functional gap junctions that interrupt molecular exchange and signal transport; the mutation can appear in GJB1 coding for connexin 32, a gap junction protein expressed in Schwann cells. Because this protein is present in oligodendrocytes, demyelination can appear in the CNS. Schwann cells create the myelin sheath, by wrapping its plasma membrane around the axon. Neurons, Schwann cells, fibroblasts work together to create a functional nerve. Schwann cells and neurons exchange molecular signals by gap junctions that regulate survival and differentiation.
Demyelinating Schwann cells causes function. They may cause axon degeneration, or they may cause axons to malfunction; the myelin sheath allows nerve cells to conduct signals faster. When the myelin sheath is damaged, nerve signals are slower, this can be measured by a common neurological test, electromyography; when the axon is damaged, this results in a reduced compound muscle action potential. CMT can be diagnosed through three different forms of tests: measurement of the speed of nerve impulses, a biopsy of the nerve, DNA testing. DNA testing can give a definitive diagnosis. CMT is first most noticed when someone develops lower leg weakness, such as foot drop, or foot deformities, including hammertoes and high arches, but signs alone do not lead to diagnosis. Patients must be referred to a physician specialising in rehabilitation medicine. To see signs of muscle weakness, the neurologist may ask patients to walk on their heels or to move part of their leg against an opposing force. To identify sensory loss, the neurologist tests for deep-tendon reflexes, such as the knee jerk, which are reduced or absent in CMT.
The doctor may ask the pa
Kriegeriales is an order of Fungi that are yeasts and can be found from a variety of places, ranging from arctic waters to tropical ferns. Most of the species now recognized as being members of Kriegeriales were for a long time placed as incertae sedis in class Microbotryomycetes; the order was described based on evidence from DNA sequence data that showed that a newly discovered Neotropical yeast genus and species, named Meredithblackwellia eburnea, was related to several unplaced species in genera Kriegeria and Glaciozyma and some other basidiomycete yeasts. Kriegeriales is divided into two families: Camptobasidiaceae. Camptobasidiaceae was described by R. T. Moore who placed it in Atractiellales However, DNA sequence data has now shown that Camptobasidium belongs to Microbotryomycetes rather than Atractiellomycetes. To date there are two genera described in Kriegeriaceae and Meredithblackwellia, two in Camptobasidiaceae and Glaciozyma. Most of the known species and strains of Kriegeriales are asexually reproducing yeasts that don’t have a known sexual state.
All are white or cream colored, with elongated cells. A handful of species have been studied in greater detail and for these it has been shown that the nuclear division of the yeast state occurs in the bud, a common character shared with most other basidiomycete yeasts. However, in M. eburnea, K. eriophori and Rhodotorula rosulata budding cells remain attached to each other at the base, forming characteristic clusters of cells that are otherwise unknown in basidiomycete yeasts. The species in Glaciozyma differ in. Only two members of Kriegeriales are known to form hyphal cells. Of these, K. eriophori has an asexual yeast state, leaving C. hydrophilum as the only species in the entire order, hyphal throughout its life cycle. Ultrastructural studies of these two hyphal species have determined that they have simple septal pores, as is true for all other known Pucciniomycotina. Species of Kriegeriales can be found in a variety of ecological niches; the members known to date include plant parasites, aquatic fungi, saprobes, or have unknown roles in nature.
Some have been isolated from psychrophilic environments and are associated with glaciers or the Antarctic sea. For example Glaciozyma antarctica was one of the first basidiomycete yeasts isolated from the Antarctic sea. Others have been isolated from the leaf surfaces of various plants both from temperate and tropical regions. Family Kriegeriaceae: Kriegeria eriophori Meredithblackwellia eburnea Rhodotorula glacialis Rhodotorula himalayensis Rhodotorula pilatii Rhodotorula psychrophenolica Rhodotorula psychrophila Rhodotorula rosulata Rhodotorula sp. KRP3844 Rhodotorula sp. FK.2.1 Rhodotorula sp. CBS11784Family Camptobasidiaceae: Camptobasidium hydrophilum Glaciozyma antarctica Glaciozyma watsonii Glaciozyma martinii Leucosporidium sp. AY30
Louis Rivier was a Swiss painter and stained glass artist. His father William Rivier was the pastor of the Free Church of Vaud. Louis was drawn to painting by Paul Robert. A member beginning in 1901 of the Waldensian Society of Fine Arts, which he would chair between 1929 and 1932, he moved to Paris in 1904 to learn painting and worked in the studio of Jean-Paul Laurens at the Académie Julian, he traveled to Belgium and Italy, fascinated by the primitive Flemish and Italian Renaissance. He exhibited at the Salon de la Société nationale des beaux-arts in Paris in 1914. Though he was a member of the Protestant Church and supported by the elite, Louis managed to break the mistrust of his church. From religious inspiration, elevated to the rank of "art missionary," his work is found in Protestant churches as frescoes or stained glass, notably in Mex, Denezy, Bottens or in the Lausanne churches of Terreaux, de Villard or de Saint-Jean de Cour, he is the author of 17 stained glass windows in the cathedral of Lausanne.
He decorated the Greek Orthodox Church of Lausanne Agios Gerassimos. In 1910, lacking the means to achieve before 1906 the paintings provided by the architect Gaspard André, Louis Rivier offered a monumental decoration for the Palais de Rumine. In 1914 Jean-Jacques Mercier offered to finance the artist for the duration of the work; the work of l'Aula began in 1915, which would last until 1923 and represented 1,000 square meters of paint. The style Rivier chose was in harmony historicist architecture of the palace and the destination of l'Aula; the mural combines science and religion in the service of uplifting humanity, a religious character consistent with the outcome of the Reformation. But the work of Rivier expresses an ambivalent feeling towards science which to certain details of the work, we note that it is rather subject to theology which he matches, in a medieval vision from their reports; the sides which are represented by twelve allegorical figures of faculties are overhung by an entire vault dedicated to religion.
On April 21, 1923, the newly transformed l'aula was the setting for the Conférence de Lausanne sur le Moyen-Orient. The decoration of l'Aula of the Palais de Rumine made the artist celebrated in the region thanks to laudatory book reviews published in the press, it won its author the title of Dr. Honoris causa of the University of Lausanne. In 1925, Rivier exhibited his works at the Grenette in front of the palace, it would attend other international exhibitions of sacred art. He became a recognized painter, a member of fine art societies in London, etc, his art criticism developed along with a biography devoted to the painter Paul Robert. Between 1937 and 1939, Rivier abandoned the tempera and invented a special process combining crayons, paint thinner and spray. In 1940, self-portrait in red and beret among the collection of the Uffizi Gallery in Florence, but if Rivier's technique evolved, his classic sources of inspiration hardly changed. The post-war period left it marginalized if its production characterized by easel painting and large murals continued to be appreciated in German Switzerland and abroad where he received a gold medal at the Salon de la Société des artistes français à Paris in 1949 and the Conseil supérieur des récompenses "Arts, Lettres" in Paris in 1958.
A major solo exhibition was dedicated to him in Rome in 1952. He became a corresponding member of the Institut de France and the Royal Society of Arts in London in 1948 and 1952, respectively. After 1963, various exhibitions were held in Switzerland, notably at the Musée cantonal des Beaux-Arts in Lausanne in 1985, the Kunsthaus in Aarau in 1986, at the Galerie Paul Vallotton in Lausanne in 1993, the Musée historique de Lausanne in 2013, on the fiftieth anniversary of the artist's death. "Louis Rivier". SIKART dictionary and database. Louis Rivier, Le peintre Paul Robert, Delachaux et Niestlé, Neuchâtel et Paris, 1927 Richard Heyd, Delachaux et Niestlé, Neuchâtel et Paris, 1943 Francesco Sapori, Libera Signoria delle Arti, Roma, 1952 Dictionnaire biographique de l'art suisse, Zurich, 1998, vol. 2, p. 877-878 Dario Gamboni, Louis Rivier et la peinture religieuse en Suisse romande, Payot Lausanne, 1985 Arthur-Louis Hofer, Eglise de Saint-Jean Lausanne, Editions Belle Rivière, Lausanne, 1997 Dave Lüthi, Les chapelles de l'Eglise libre vaudoise, Lausanne, 2000, p. 175-179 This article incorporates public domain material from websites or documents of the United States Department of Homeland Security.
Véronique Mauron, Marie-Odile Vaudou, Marie André, Anne Chaves-Rivier, Laurent Golay, François Boespflug, Edith Carey, David Auberson,Christophe Gallaz, Louis Rivier, L'intimité transfigurée, Till Schaap éditions, Berne, 2013 Page dedicated Louis Rivier Site of the Association of the Friends of Louis Rivier bibliographie
Lukhdhirji Engineering College,Morbi popularly known as L. E. College or LEC Morbi is located in the Morbi district, it was established as a polytechnic in 1931 known as Morvi Technical Institute and was upgraded to a full-fledged degree engineering college in 1951 when the Late Honorable H. H. Maharaja Thakore Shri Sir Lukhdhirji Waghji Sahib Bahadur GBE KCSI of Morvi state donated his palace with 40 acres of land on the bank of river Machhu and the institute was named after him; the institute is operated by the government of Gujarat and is affiliated with Gujarat Technological University. In 1951 The Late Honorable H. H. Maharaja Thakore Shri Sir Lukhdhirji Waghji Sahib Bahadur GBE KCSI of Morvi met Professor Sunder Singh Bhatia from the Dayalbagh Educational Institute and asked him to upgrade the Morvi Technical Institute to a full-fledged degree engineering college and become its first principal; the Maharaja had four palaces. The Nazarbag palace was donated to become. Another two palaces became the principal's private residence respectively.
The fourth palace was retained by the Maharaja as his personal residence. The campus is located on the banks of river Machhu in Gujarat; the campus is divided into clusters of buildings. The academic area consists of various departmental buildings, the administration block, the students amenities building, a badminton court and swimming pool; the academic area is divided into old campus and new campus: Old Campus: New Campus: Further college has separate boys and girls hostel which can accommodate around 1200 students. The hostel campus occupies the area of around 25 acres. Hostel Machhu A, Machhu B, Machhu D, Machhu E, New Hill, NVP and New Hostel are for boys and Hostel Machhu F & Machhu G are for girls; the college has its own cricket ground with pavilion. The institute has ten major academic departments: Department of Electrical Engineering Department of Civil Engineering Department of Mechanical Engineering Department of IT Engineering Department of Production Engineering Department of Chemical Engineering Department of Industrial Engineering Department of Power Electronics Engineering General Department Applied Mechanics DepartmentSiemens, in association with Government of Gujarat, has established a Center of Excellence in Industrial Machinery on the campus.
It organizes several certification courses like PLC Scada, NX and NX Advance, Induction Motor Training. Apart from conventional departments, L. E. College Morbi has several other important organizations and cells which are run jointly by students and institute and cater to the purpose as defined in their respective charter. Following aims; the association organizes reunion every year and along with it they organize'Annual Gold Medal Award Function' in which toppers of the most recent graduated batch are awarded a gold medal and a certificate by the alumni association. The institute is a part of Rajkot Battalion of NCC; the cadets from this institute participates in the camps and drills organized by NCC at state and national level and has brought laurels for the institute. Presently it is mentored by Prof. K. K. Dave from Mechanical Engineering Department; this department of established in 2012 by principle Prof. P. C. Vasani in order to promote extra curricular activities in the institute. Since its inception, COC has organized 4 techfests, several cultural activities such as Saptdhara, Matru Bhasa Divas, Annual Open House etc.
The department is one of the most dynamic department of the institute which organizes curricular and extra curricular activities and thus provides the platform to the students to showcase their talents and nurture their temperament. The department is chaired by Prof. M. H. Ayalani and has several dynamic and enthusiastic faculties associated with it like Prof. K. K. Dave, Prof. Jagruti Bheda etc. Electrical Engineering Students Association is a local student chapter at Electrical Engineering Department established by the enthusiasts of 2016 batch. Apart from technical lectures, symposiums etc. EESA organizes various non technical activities at the departmental level such as Welcome & Farewell Functions, College Days, Departmental Day etc. Training and placement cell was established in the year 1962. L. E. College Morbi gives equal emphasis on sports and every year Annual Sports Week is organized in the semester and various tournaments are organized in this week covering wide range of sports such as Volleyball, Badminton etc.
Students of L. E. College participate in University Sports Meets and National Sports Meet. College sports teams have bought laurels in various games like Cricket, Kho-Kho etc. in past. Vijayant is the annual techfest of the institute, its first edition was pioneered by 2012 batch and thus from onward, the fest is organized every year with great enthusiasm and attracts participation from different institutes across the state. The latest edition of VIJAYANT was organized on 19 and 20 March 2015, it had more than 1600 students participated in it. The theme of the techfest was'Born to Win'. Mr Arjun Modhwadia, Ex. Leader of Opposition, Gujarat Assembly Raghavan Iyengar, IT Professional Lukhdhirji Engineering College Lenco Alumni Association
Dusty Grave is an American musician, the lead singer and founder of Stellar Corpses. Dusty grew up in Santa Cruz, California playing in various punk rock and rockabilly bands; as a teen he worked at a FedEx Office. There he learned web and graphic design which he now does for a living in addition to playing music. Dusty founded Stellar Corpses in 2005, he came up with the band name, an astronomy term for a dead star as well as the logo while in college pursuing a degree in psychology. Much of the band's aesthetic is based around The Lost Boys film. Between 2005 and 2016 Stellar Corpses released their Respect the Dead EP and two full length albums: Welcome to the Nightmare and Dead Stars Drive-In along with extensive touring throughout Europe, USA and Mexico. Dead Stars Drive-In featured several notable guest musicians including Hunter Burgan, Jade Puget, Mike Fasano and Michael Graves; the album was engineered by Joe McGrath. The lead single from the album "Vampire Kiss" debuted at No. 9 on the alternative music charts.
In Aug 2017 Stellar Corpses was signed to Atomic Music Group, one of the biggest talent booking agencies in the United States. In 2019 Stellar Corpses members resigned due to demanding tour schedule, leaving Dusty as the sole original member. New members include Sky Vaughan-Jayne on guitar and backing vocals, Maniacal Maniacal from Rezurex on bass, Jack Cash on guitar and Todd Bowen on drums. Stellar Corpses toured with the new lineup in Fall 2019 along with Nekromantix. In 2016 Dusty moved to Los Angeles, he started the label as a way to promote the underground music scene. He announced the label along with acoustic performances in the original Bat Cave in Griffith Park; the first Batcave Records release was Stellar Corpses Hellbound Heart EP. In August 2019, Batcave Records and Cleopatra Records signed a partnership deal for future Batcave Records releases. In April 2018 Dusty co-founded BAT!, offered a record deal by Cleopatra Records after their first show. BAT! Includes Dusty as well as Rene Delamuerte from Nekromantix / The Brains and Daniel deLeon from Rezurex.
BAT! has been described as "reminiscent of The Damned, The Cramps and the Stray Cats, they enlist the help of fetish models and Dominatrixes to punish evildoers on stage."In May 10, 2019 BAT!'s first Album Bat Music For Bat People was released on Cleopatra Records in association with Batcave Records. They toured in the US playing lead guitar for Rezurex in support of Nekromantix. Dusty has talked about his struggles with alcohol and drug addiction, he first got sober in 2004 but relapsed during Stellar Corpses first tour in 2007. He crashed and totaled his car while drunk driving with police saying he should’ve died, he went to jail for the 13th time. In September 2009 he has remained drug and alcohol free. Dusty is a vegan
Eastland County is a county located in West-central Texas. As of the 2010 census, its population was 18,583; the county seat is Eastland. The county was founded in 1858 and organized in 1873, it is named for William Mosby Eastland, a soldier during the Texas Revolution and the only officer to die as a result of the "Black Bean executions" of the Mier Expedition. Two Eastland County communities and Ranger, have junior colleges. According to the U. S. Census Bureau, the county has a total area of 932 square miles, of which 926 square miles are land and 5.4 square miles are covered by water. Interstate 20 U. S. Highway 183 State Highway 6 State Highway 16 State Highway 36 State Highway 112 Stephens County Palo Pinto County Erath County Comanche County Brown County Callahan County Shackelford County As of the census of 2000, 18,297 people, 7,321 households, 5,036 families resided in the county; the population density was 20 people per square mile. The 9,547 housing units averaged 10 per square mile; the racial makeup of the county was 91.03% White, 2.18% African American, 0.48% Native American, 0.21% Asian, 0.02% Pacific Islander, 4.83% from other races, 1.25% from two or more races.
About 10.80 % of the population was Latino of any race. Of the 7,321 households, 27.70% had children under the age of 18 living with them, 55.40% were married couples living together, 9.50% had a female householder with no husband present, 31.20% were not families. About 28.6% of all households were made up of individuals, 16.20% had someone living alone, 65 years of age or older. The average household size was 2.39 and the average family size was 2.93. In the county, the population was distributed as 23.20% under the age of 18, 9.80% from 18 to 24, 22.30% from 25 to 44, 23.90% from 45 to 64, 20.90% who were 65 years of age or older. The median age was 41 years. For every 100 females, there were 94.10 males. For every 100 females age 18 and over, there were 90.60 males. The median income for a household in the county was $26,832, for a family was $33,562. Males had a median income of $25,598 versus $17,112 for females; the per capita income for the county was $14,870. About 12.10% of families and 16.80% of the population were below the poverty line, including 23.10% of those under age 18 and 14.80% of those age 65 or over.
Despite its small population, the county is home to two community colleges – Cisco College and Ranger College, located in their respective towns. Eastland County is part of the Abilene/Sweetwater/Brownwood television viewing area in West-central Texas. Local news media outlets include: KRBC-TV, KTXS-TV, KXVA, KTAB-TV. In the cities of Eastland and Cisco on Suddenlink Communications Cable Television service, residents can view the Dallas/Fort Worth market stations WFAA-TV and KERA-TV. Eastland County is served by four local newspapers: the Eastland Telegram, the Rising Star, Ranger Times, the Cisco Press. Cisco Eastland Gorman Ranger Carbon Rising Star Morton Valley Nimrod Olden Romney Desdemona Mangum National Register of Historic Places listings in Eastland County, Texas Recorded Texas Historic Landmarks in Eastland County Santa Claus Bank Robbery Eastland County government's website Eastland County in Handbook of Texas Online at the University of Texas Eastland-Callahan County Newspapers