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Charles A. Busiel

Charles Albert Busiel was an American manufacturer and the forty-fifth Governor of New Hampshire. Born at Meredith Village, New Hampshire, Busiel was educated at the public schools and Gilford Academy, he worked in the family hosiery mill training in all departments of the mill to learn the business. In 1863, he purchased the Pitman Manufactory, which he ran for a few years sold, he and two brothers continued in hosiery, he invested in railroads expanded into the banking and publishing industries. Elected as a Democrat in 1878, Busiel was a representative in the New Hampshire House of Representatives, he served several years as mayor of Laconia. In 1894, Busiel was elected Governor of New Hampshire and served from January 3, 1895 to January 7, 1897. During his tenure, financial programs were initiated to boost the state's economy, electric trolley and railroad services were promoted, he was President of the City Savings Bank. He was President of Lake Shore Director of the Concord & Montreal Railroad.

He was a delegate to Democratic National Convention from New Hampshire, 1880, mayor of Laconia, New Hampshire, 1893-1895. Busiel died August 1901, of coronary heart disease in Laconia, his death was less than two weeks after the death by drowning of his grandson and namesake, Charles Busiel Smith. He is interred in a mausoleum at the Union Cemetery in New Hampshire; the son of John W. and Julia Busiel, Busiel married, on November 21, 1864, Eunice Elizabeth Preston, daughter of Worcester and Nancy Preston, a native of Concord, New Hampshire. They had one child, Frances Evelyn Busiel, who married Wilson Longstreth Smith of Germantown, Pennsylvania. Busiel at New Hampshire's Division of Historic Resources Digital images.

HSD17B1

17β-Hydroxysteroid dehydrogenase 1 is an enzyme that in humans is encoded by the HSD17B1 gene. This enzyme oxidizes or reduces the C17 hydroxy/keto group of androgens and estrogens and hence is able to regulate the potency of these sex steroids This enzyme is responsible for the interconversion of estrone and estradiol and for the interconversion of androstenedione and testosterone: 17β-estradiol + NADP+ + ⇌ estrone + NADPH + H+ testosterone + NADP+ + ⇌ androstenedione + NADPH + H+The human 17β-HSD1 isozyme is specific for estrogens over androgens whereas the rodent isozyme is less specific. Human 17β-HSD1 was the first enzyme of the 17β-HSD family to be cloned and to have its sequence identified, its three-dimensional structure is the first example of any human steroid-converting enzyme. This enzyme contains a short-chain dehydrogenase domain that contains a characteristic 3-layer sandwich known as a Rossmann fold; the human enzyme contains 327 amino acids and exists as a homodimer with two identical subunits of 34.5 kDa The N-terminal short-chain dehydrogenase domain contains binding site for the NADP+/NADPH cofactor.

A narrow, hydrophobic C-terminal domain contains a binding pocket for the steroid substrate. Estradiol stimulates. Furthermore 17β-HSD1 levels positively correlate with estradiol and negatively correlate with DHT levels in breast cancer cells. Hence 17β-HSD1 represents a possible drug target for breast cancer treatment. 17β-Hydroxysteroid dehydrogenase

Jewish Historical Documentation Centre

The Jewish Historical Documentation Centre was an office headed by Simon Wiesenthal in Linz. The centre collected and promulgated information about war crimes, specific to crimes against the Jewish people as perpetrated by the Nazi Regime in Europe during the Second World War; the centre has been responsible for uncovering more than 1000 Nazi war criminals, including Adolf Eichmann, sometimes referred to as "the architect of the Holocaust". The office was interested in the whereabouts of alleged Nazi war criminals who may have escaped justice, including those individuals who escaped through the Nazi ratlines to havens in South America to Argentina, Paraguay and Chile; this Centre closed in 1954. Simon Wiesenthal was a Holocaust survivor, noted for his work as a Nazi hunter who pursued Nazi war criminals. After being liberated from the Mauthausen-Gusen concentration camp by the U. S. Army, Wiesenthal began gathering and preparing evidence on Nazi atrocities for the War Crimes Section of the United States Army.

When his association with the United States Army ended in 1947, Wiesenthal and thirty volunteers opened the Jewish Historical Documentation Centre in Linz, for the purpose of assembling evidence for future trials. However, as the Cold War between the United States and the Soviet Union intensified, both sides lost interest in prosecuting Germans, Wiesenthal's volunteers, succumbing to frustration, drifted away to more ordinary pursuits. In 1954, the office in Linz was closed, its files were given to the Yad Vashem Archives in Israel, except for the dossier on Adolf Eichmann. In 1959, acting on information provided by Wiesenthal and other Nazi hunters, Eichmann was captured by Mossad agents in Argentina, transported to Israel where he was tried and executed. Encouraged, in 1961, Simon Wiesenthal founded the Documentation Centre of the Association of Jewish Victims of the Nazi Regime in Vienna, which concentrated on the hunting of war criminals; the centre in Vienna was housed in a nondescript, sparsely furnished three-room office in Vienna's old Jewish quarter with a staff of four, including Wiesenthal The centre had open files on about 2,000 cases, Wiesenthal estimated that about 150,000 Nazis were involved in war crimes and that his office's extensive archives were just "the tip of the iceberg".

According to the centre, about 40,000 Nazis have been tried for war crimes since the end of the war, most were found guilty. The centre developed a department to track right-wing extremism. Since 2003, the association has been indexing its holdings with the aid of an electronic database to increase its availability for users; the Centre is an integral, but independent part of the Vienna Wiesenthal Institute for Holocaust Studies. Center of Contemporary Jewish Documentation Simon Wiesenthal, I Have Never Forgotten You, SWC, California, 2007 Simon Wiesenthal Archive