Center of Media Education petitioned the Federal Trade Commission to investigate the data collection and use practices of the KidsCom.com website, take legal action since the data practices violated Section 5 of FTC Act concerning "unfair/deceptive practices". After the FTC completed its investigation, it issued the "KidsCom Letter" the report stated that the data collection and use practices were indeed subject to legal action; this resulted in the need to inform parents about the risks of children's online privacy, as well as to parental consent necessity. This utimately resulted in the drafting of COPPA; the Federal Trade Commission has the authority to issue regulations and enforce COPPA. Under the terms of COPPA, the FTC-designated "safe harbor" provisioning is designed to encourage increased industry self-regulation. Under this provision, industry groups and others may request Commission approval of self-regulatory guidelines to govern participants' compliance, such that website operators in Commission-approved programs would first be subject to the disciplinary procedures of the safe harbor program in lieu of FTC enforcement.
As of June 2016, the FTC has approved seven safe harbor programs operated by TRUSTe, ESRB, CARU, PRIVO, Inc. Samet Privacy, the Internet Keep Safe Coalition. In September 2011, the FTC announced proposed revisions to the COPPA rules, the first significant changes to the act since the issuance of the rules in 2000; the proposed rule changes expanded the definition of from children. The proposed rules presented a data retention and deletion requirement, which mandated that data obtained from children be retained only for the amount of time necessary to achieve the purpose that it was collected for, it added the requirement that operators ensure that any third parties to whom a child's information is disclosed have reasonable procedures in place to protect the information. The act applies to websites and online services operated for commercial purposes that are either directed towards children under 13 or have actual knowledge that children under 13 are providing information online. Most recognized non-profit organizations are exempt from most of the requirements of COPPA.
However, the Supreme Court ruled that non-profits operated for the benefit of their members' commercial activities are subject to FTC regulation and COPPA as well. The type of "verifiable parental consent", required before collecting and using information provided by children under 13 is based upon a "sliding scale" set forth in a Federal Trade Commission regulation that takes into account the manner in which the information is being collected and the uses to which the information will be put; the FTC has brought a number of actions against website operators for failure to comply with COPPA requirements, including actions against Girls' Life, American Pop Corn Company, Lisa Frank, Inc. Mrs. Fields Cookies, The Hershey Company. In February 2004, UMG Recordings, Inc. was fined US$400,000 for COPPA violations in connection with a web site that promoted the 13-year-old pop star Lil' Romeo and hosted child-oriented games and activities, Bonzi Software, which offered downloads of an animated figure "BonziBuddy" that provided shopping advice and trivia was fined US$75,000 for COPPA violations.
The owners of the Xanga website were fined US$1 million in 2006 for COPPA violations of allowing children under 13 to sign up for the service without getting their parent's consent. In 2016, the mobile advertising network inMobi was fined US$950,000 for tracking the geo-location of all users without their knowledge; the advertising software continuously tracked user location despite privacy preferences on the mobile device. Other websites that were directed towards children and fined due to COPPA include Imbee and Skid-e-Kids. In February 2019, the FTC issued a fine of $5.7 million to ByteDance for failing to comply with COPPA with their TikTok app. Byte Dance agreed to pay the largest COPPA fine since the bill's enactment and to add a kids-only mode to the TikTok app. Three dating apps by Wildec were pulled by Apple and Google from their respective app stores, after the FTC determined that the dating apps allowed users under 13 to register, that Wildec knew there were significant numbers of minor users, that this allowed inappropriate contact with minors.
On September 4, 2019, the FTC issued a fine of $17
The African Lion Safari was a wildlife park that Stafford Bullen opened in 1968. It operated near Warragamba on the outskirts of Sydney in New South Wales, Australia until 1991. There was a dolphinarium in the African Lion Safari. African Lion Safari was opened by Stafford Bullen in 1968. At the time, Bullen was still operating a travelling circus, but in 1969 he gave this venture a permanent home at Bullen's Animal World. For the opening, a promotional single of The Tokens' "The Lion Sleeps Tonight" was recorded by a band using the name "The Love machine"; the safari attracted up to 200,000 visitors each year. With the suburbs encroaching on the facility, extensive work required to upgrade the park following legislative changes, it closed in 1991 but continued to hold animals on site that were used in a circus but not displayed to the public. African Lion Safari opened in Warragamba, however sometime after this it relocated to neighbouring Wallacia, where it had a drive through area full of wild animals i.e. lions and tigers.
On 7 August 1995, several lionesses escaped from the park, roamed the nearby townships of Warragamba and Silverdale, killed a dog. The lioness responsible for killing the dog was shot by a park employee; as a result of the escape, the park was required to upgrade facilities. A bear escaped and was shot by residents, as reported by Michael Feeny "Dynasties: The Bullen Family". Abc.net.au. ABC Australia. 4 December 2006. Archived from the original on 30 December 2016. Retrieved 27 September 2010. 1980s Television Commercial on Youtube
Category F5 is the seventh studio album by American rapper Twista. The album marks the first collaboration with Chicago producer the Legendary Traxster since 2004's Kamikaze; the album was released on July 14, 2009. Scheduled to feature Kanye West, Busta Rhymes, Mr. Criminal, Tech N9ne, Static Major, guest appearances were pared down as many of the leaked songs were recorded, including the song "Problems" featuring Tech N9ne, cut because of sample-clearance problems; the track "She Got It" was cut because the tracks were not 100% ready, although it is thought the track will be made available in the coming months. "All Right" was included on iTunes as a bonus track. Notes "Birthday" features additional vocals performed by Marlin "Hookman" Bonds
GW501516 is a PPARδ receptor agonist, invented in a collaboration between Ligand Pharmaceuticals and GlaxoSmithKline in the 1990s, was entered into clinical development as a drug candidate for metabolic diseases and cardiovascular diseases, was abandoned in 2007 because animal testing showed that the drug caused cancer to develop in several organs. In 2007, research was published showing that high doses of GW501516 given to mice improved their physical performance; the World Anti-Doping Agency developed a test for GW501516 and other related chemicals and added them to the prohibited list in 2009. GW501516 was discovered during a research collaboration between GSK and Ligand Pharmaceuticals that began in 1992; the discovery of the compound was published in a 2001 issue of PNAS. Oliver et al. reported that they used "combinatorial chemistry and structure-based drug design" to develop it. One of the authors was the son of Leo Sternbach. R & D Focus Drug News reported that GSK began phase I trials of the compound for the treatment of hyperlipidemia in 2000 followed by phase I/II in 2002.
In 2003, Ligand Pharmaceuticals earned a $1 million payment as a result of GSK continuing phase I development. By 2007, GW501516 had completed two phase II clinical studies and other studies relating to obesity, diabetes and cardiovascular disease, but GSK abandoned further development of the drug in 2007 for reasons which were not disclosed at the time, it emerged that the drug was discontinued because animal testing showed that the drug caused cancer to develop in several organs, at dosages of 3 mg/kg/day in both mice and rats. Ronald M. Evans's laboratory purchased a sample of GW501516 and gave mice a much higher dose than had been used in GSK's experiments; the work was published in 2007 in Cell and was reported in the popular press including The New York Times and The Wall Street Journal. Concerns were raised prior to the 2008 Beijing Olympics that GW501516 could be used by athletes as an ergogenic performance-enhancing drug, not controlled by regulations or detected by standard tests.
One of the main researchers from the study on enhanced endurance developed a urine test to detect the drug, made it available to the International Olympic Committee. The World Anti-Doping Agency developed a test for GW501516 and other related PPARδ modulators, added such drugs to the prohibited list in 2009. GW501516 has been promoted on bodybuilding and athletics websites and by 2011 had been available for some time on the black market. In 2011, it was reported to cost $1,000 for 10 g. In 2012, WADA recategorised GW501516 from a gene doping compound to a "hormone and metabolic modulator". In 2013, WADA took the rare step of warning potential users of the compound of the possible health risks, stating that "clinical approval has not, will not be given for this substance". A number of athletes have tested positive for GW501516. At the Vuelta Ciclista a Costa Rica in December 2012, four Costa Rican riders tested positive for GW501516. Three of them received two-year suspensions, while the fourth received 12 years as it was his second doping violation.
In April 2013, Russian cyclist Valery Kaykov was suspended by cycling's governing body UCI after having tested positive for GW501516. Kaykov's team RusVelo dismissed him and in May 2013, Venezuelan Miguel Ubeto was provisionally suspended by the Lampre team. In February 2014, Russian race walker Elena Lashmanova tested positive for GW501516. In April 2019, heavyweight boxer Jarrell Miller tested positive for GW501516 which caused his challenge for Anthony Joshua's World Heavyweight titles to be cancelled. GW501516 is a selective agonist of the PPARδ receptor, it displays high affinity and potency for PPARδ with > 1,000 fold selectivity over PPARα and PPARγ. In rats, binding of GW501516 to PPARδ recruits the coactivator PGC-1α; the PPARδ/coactivator complex in turn upregulates the expression of proteins involved in energy expenditure. Furthermore, in rats treated with GW501516, increased fatty acid metabolism in skeletal muscle and protection against diet-induced obesity and type II diabetes was observed.
In obese rhesus monkeys, GW501516 increased high-density lipoprotein and lowered very-low-density lipoprotein. Acadesine GFT505 GW0742 Irisin Peroxisome proliferator-activated receptor Sodelglitazar SR9009
Holland McTyeire Thompson, was an American historian who wrote about the New South. Thompson was born in North Carolina, he graduated from the University of North Carolina. Thompson served as a high school principal at Concord High School in Concord, North Carolina from 1895–99, where he wrote an essay about the transformation of southern culture from a rural agricultural to textile/manufacturing way of life that he witnessed while an educator in Concord; this essay, in part, gained Thompson admittance to Columbia University where he received his Ph. D. in 1901, became a full professor of history at City College of New York. Thompson, while professor at CCNY, was among the leading scholar/historians of the social and industrial transformation of the New South in the early decades of the 20th century. Thompson married Isobel Graham Aitken of New York in 1905, they had one son, Lawrence. Thompson died on October 21, 1940. From the Cotton Field to the Cotton Mill: A Study of the Industrial Transition in North Carolina.
New York: Macmillan. OCLC 16411826 The New South: A Chronicle of Social and Industrial Evolution Yale Chronicles of America Series. New Haven: Yale University Press. OCLC 17361006 The Age of Invention: A Chronicle of Mechanical Conquest. New Haven: Yale University Press. OCLC 3616164 "Holland Thompson, 1873-1940". Retrieved 2008-05-19. Works by Holland Thompson at Project Gutenberg Works by or about Holland Thompson at Internet Archive
Zohmingliana Ralte is an Indian professional footballer who plays as a defender for Chennaiyin FC in the Indian Super League. Born in Aizawl, Ralte began his career at the academy of Mohun Bagan in 2005 before leaving the academy after one year due to being homesick, he joined the Rangdajied United youth team in 2007 before joining Shillong Lajong in 2008. While with Shillong Lajong Ralte played in the I-League and I-League 2nd Division. On 30 July 2012 it was announced that Ralte had signed with Pune F. C. of the I-League on a two-year deal. He made his league debut for Pune on 5 January 2013 against United Sikkim when he came on as a 92nd-minute substitute for James Moga. Ralte scored his first professional goal on 24 May 2015 as he headed in Arata Izumi's deflected corner in the sixth minute, in what proved to be the only goal in a 1-0 victory over his former club Shillong Lajong. In July 2015 Ralte was drafted to play for NorthEast United FC in the 2015 Indian Super League. Ralte signed for DSK Shivajians for one season.
In December 2016, Ralte signed for his home side Aizawl F. C. for 2016-17 I-League season. He guided them to lift the maiden I-League trophy. Ralte scored a crucial goal against Mohun Bagan, known to be the title winning goal of the season. On July 23rd 2017, Ralte was drafted to Bengaluru FC for upcoming ISL 2017-18. Aizawl FCI-League: 2016–17 Pune Football Club Profile