Children's Hospital Los Angeles (CHLA) is a nationally ranked, freestanding acute care children's hospital in the East Hollywood district of Los Angeles, on Sunset Boulevard at the corner of Vermont Avenue. The hospital has been academically affiliated with the Keck School of Medicine of the University of Southern California since 1932 and the hospital features 401 pediatric beds. The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults generally aged 0–21 throughout California and the west coast. The hospital also sometimes treats adults that require pediatric care. The hospital has a rooftop helipad and is an ACS verified level I pediatric trauma center, one of a few in the region. The hospital features a regional pediatric intensive-care unit and an American Academy of Pediatrics verified level IV neonatal intensive care unit.

East Hollywood is a densely populated neighborhood of 78,000+ residents that is part of the Hollywood area of the central region of Los Angeles, California. It is notable for being the site of Los Angeles City College, Barnsdall Park, and a hospital district. There are seven public and five private schools, a Los Angeles Public Library branch, and three hospitals. Almost two-thirds of the people living there were born outside the United States, and 90% were renters. In 2000, the neighborhood had high percentages of never-married people and single parents.