Children's Hospital Los Angeles (CHLA) is a nationally ranked, freestanding acute care children's hospital in the East Hollywood district of Los Angeles, on Sunset Boulevard at the corner of Vermont Avenue. The hospital has been academically affiliated with the Keck School of Medicine of the University of Southern California since 1932 and the hospital features 401 pediatric beds. The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults generally aged 0–21 throughout California and the west coast. The hospital also sometimes treats adults that require pediatric care. The hospital has a rooftop helipad and is an ACS verified level I pediatric trauma center, one of a few in the region. The hospital features a regional pediatric intensive-care unit and an American Academy of Pediatrics verified level IV neonatal intensive care unit.

UCLA Mattel Children's Hospital (MCH) at Ronald Reagan UCLA Medical Center is a nationally ranked pediatric acute care children's hospital located in Los Angeles, California. The hospital has 156 pediatric beds, is affiliated with the University of California, Los Angeles David Geffen School of Medicine, and is a member of UCLA Health. The hospital provides comprehensive pediatric specialties and subspecialties to pediatric patients aged 0–21 throughout California. Mattel Children's also sometimes treats adults that require pediatric care. UCLA Mattel Children's Hospital features an ACS verified pediatric level 1 trauma center. The UCLA Mattel Children's Hospital is located on the third and fifth floors of the newly constructed Ronald Reagan UCLA Medical Center.