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Skeletal formula
Ball-and-stick model of chlorphentermine
Clinical data
Synonyms p-Chloro-α,α-dimethylphenethylamine
Routes of
Oral, Insufflated, Rectal
ATC code
Legal status
Legal status
Pharmacokinetic data
Elimination half-life 40 hours
Excretion Renal
CAS Number
PubChem CID
ECHA InfoCard 100.006.651 Edit this at Wikidata
Chemical and physical data
Formula C10H14ClN
Molar mass 183.68 g/mol
3D model (JSmol)
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Chlorphentermine (trade names Apsedon, Desopimon, Lucofen) is a serotonergic appetite suppressant of the amphetamine family. Developed in 1962, it is the 4-chloro derivative of the better known appetite suppressant phentermine,[1] which is still in current use.

Chlorphentermine acts as a highly selective serotonin releasing agent (SRA).[2] It is not a psychostimulant and has little or no abuse potential, but is classed as a Schedule III drug in the USA due mainly to its similarity to other appetite suppressants such as diethylpropion which have been more widely abused. It is no longer used due mainly to safety concerns, as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex which were found to cause pulmonary hypertension and cardiac fibrosis following prolonged use.[3]

The plasma half-life is about five days.[4] It was withdrawn from the market in the UK in 1974.[4]

See also[edit]


  1. ^ Gylys, JA; Hart, JJ; Warren, MR (Sep 1962). "Chlorphentermine, a new anorectic agent". Journal of Pharmacology and Experimental Therapeutics. 137: 365–73. 
  2. ^ Rothman RB, Baumann MH, Dersch CM, Romero DV, Rice KC, Carroll FI, et al. (2001). "Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin". Synapse. 39 (1): 32–41. doi:10.1002/1098-2396(20010101)39:1<32::AID-SYN5>3.0.CO;2-3. PMID 11071707. 
  3. ^ Rothman, RB; Ayestas, MA; Dersch, CM; Baumann, MH (Aug 1999). "Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension". Circulation. 100 (8): 869–75. doi:10.1161/01.cir.100.8.869. 
  4. ^ a b Craddock, D (1976). "Anorectic drugs: use in general practice". Drugs. 11 (5): 378–93. doi:10.2165/00003495-197611050-00002. PMID 782835.