A US Navy general surgeon and an operating room nurse performing a laparoscopic cholecystectomy
Cholecystectomy is the surgical removal of the gallbladder. Cholecystectomy is a common treatment of symptomatic gallstones and other gallbladder conditions; in 2011, cholecystectomy was the 8th most common operating room procedure performed in hospitals in the United States. Cholecystectomy can be performed either laparoscopically, using a video camera, or via an open surgical technique.[page needed]
The surgery is usually successful in relieving symptoms, but up to 10% of people may continue to experience similar symptoms after cholecystectomy, a condition called postcholecystectomy syndrome. Complications of cholecystectomy include bile duct injury, wound infection, bleeding, retained gallstones, abscess formation and stenosis (narrowing) of the bile duct.
- 1 Medical use
- 2 Contraindications
- 3 Risks and complications
- 4 Procedure
- 5 Long-term prognosis
- 6 Considerations
- 7 Alternatives to surgery
- 8 Epidemiology
- 9 History
- 10 See also
- 11 Further reading
- 12 References
Pain and complications caused by gallstones are the most common reasons for removal of the gallbladder, the gallbladder can also be removed in order to treat biliary dyskinesia or gallbladder cancer.
Gallstones are incredibly common but 50–80% of people with gallstones are asymptomatic and do not need surgery; their stones are noticed incidentally on imaging tests of the abdomen (such as ultrasound or CT) done for some other reason. Of the more than 20 million people in the US with gallstones, only about 30% will eventually require cholecystectomy to relieve symptoms (pain) or treat complications.
Biliary colic, or pain caused by gallstones, occurs when a gallstone temporarily blocks the bile duct that drains the gallbladder. Typically, pain from biliary colic is felt in the right upper part of the abdomen, is moderate to severe, and goes away on its own after a few hours when the stone dislodges. Biliary colic usually occurs after meals when the gallbladder contracts to push bile out into the digestive tract, after a first attack of biliary colic, more than 90% of people will have a repeat attack in the next 10 years. Repeated attacks of biliary colic are the most common reason for removing the gallbladder, and lead to about 300,000 cholecystectomies in the US each year.
Cholecystitis, or inflammation of the gallbladder caused by interruption in the normal flow of bile, is another reason for cholecystectomy. It is the most common complication of gallstones; 90-95% of acute cholecystitis is caused by gallstones blocking drainage of the gallbladder. If the blockage is incomplete and the stone passes quickly, the person experiences biliary colic. If the gallbladder is completely blocked and remains so for a prolonged period, the person develops acute cholecystitis.
Pain in cholecystitis is similar to that of biliary colic, but lasts longer than 6 hours and occurs together with signs of infection such as fever, chills, or an elevated white blood cell count. People with cholecystitis will also usually have a positive Murphy sign on physical exam - meaning that when a doctor asks the patient to take a deep breath and then pushes down on the upper right side of their abdomen, the patient stops their inhalation due to pain from the pressure on their inflamed gallbladder.
5-10% of acute cholecystitis occurs in people without gallstones, and for this reason is called acalculous cholecystitis. It usually develops in people who have abnormal bile drainage secondary to a serious illness, such as people with multi-organ failure, serious trauma, recent major surgery, or following a long stay in the intensive care unit.
People with repeat episodes of acute cholecystitis can develop chronic cholecystitis from changes in the normal anatomy of the gallbladder, this can also be an indication for cholecystectomy if the person has ongoing pain.
Cholangitis and gallstone pancreatitis
Cholangitis and gallstone pancreatitis are rarer and more serious complications from gallstone disease. Both can occur if gallstones leave the gallbladder, pass through the cystic duct, and get stuck in the common bile duct, the common bile duct drains the liver and pancreas, and a blockage there can lead to inflammation and infection in both the pancreas and biliary system. While cholecystectomy is not usually the immediate treatment choice for either of these conditions, it is often recommended to prevent repeat episodes from additional by gallstones getting stuck.:940,1017
Gallbladder cancer (also called carcinoma of the gallbladder) is a rare indication for cholecystectomy. In cases where cancer is suspected, the open technique for cholecystectomy is usually performed.
There are no specific contraindications for cholecystectomy, and in general it is considered a low-risk surgery.
However, anyone who cannot tolerate surgery under general anesthesia should not undergo cholecystectomy. People can be split into high and low risk groups using a tool such as the ASA physical status classification system; in this system, people who are ASA categories III, IV, and V are considered high risk for cholecystectomy. Typically this includes very elderly people and people with co-existing illness, such as end-stage liver disease with portal hypertension and whose blood does not clot properly. Alternatives to surgery are briefly mentioned below.
Risks and complications
All surgery carries risk of serious complications including damage to nearby structures, bleeding, infection, or even death, the operative death rate in cholecystectomy is about 0.1% in people under age 50 and about 0.5% in people over age 50. The greatest risk of death comes from co-existing illness like cardiac or pulmonary disease.
A serious complication of cholecystectomy is biliary injury, or damage to the bile ducts. Laparoscopic cholecystectomy has a higher risk of bile duct injury than the open approach, with injury to bile ducts occurring in 0.3% to 0.5% of laparoscopic cases and 0.1% to 0.2% of open cases. In laparoscopic cholecystectomy, approximately 25-30% of biliary injuries are identified during the operation; the rest become apparent in the early post-operative period.[page needed]
Damage to the bile ducts is very serious because it causes leakage of bile into the abdomen. Signs and symptoms of a bile leak include abdominal pain, tenderness, fever and signs of sepsis several days following surgery, or through laboratory studies as rising total bilirubin and alkaline phosphatase. Complications from a bile leak can follow a person for years and can lead to death. Bile leak should always be considered in any patient who is not recovering as suspected after cholecystectomy. Most bile injuries require repair by a surgeon with special training in biliary reconstruction. If biliary injuries are properly treated and repaired, more than 90% of patients can have a long-term successful recovery.
A review of decades of safety data about in laparoscopic cholecystectomy found the following complications to be most prevalent:
|Retained stone in the common bile duct||0.50%|
Leakage from the stump of the cystic duct is a complication that is more common with the laparoscopic approach than the open approach but is still rare, occurring in less than 1% of procedures; it is treated by drainage followed by insertion of a bile duct stent.
Conversion to open cholecystectomy
Experts agree that many biliary injuries in laparoscopic cases are caused by difficulties seeing and identifying the anatomy clearly. If the surgeon has problems identifying anatomical structures, they might need to convert from laparoscopic to open cholecystectomy.
Before surgery, a complete blood count and liver function tests are usually obtained. Prophylactic treatment is given to prevent deep vein thrombosis. Use of prophylactic antibiotics is controversial; however, a dose may be given prior to surgery to prevent infection in certain people at high risk. Gas may be removed from the stomach with an OG or NG tube. A Foley catheter may be used to empty the patient's bladder.
Laparoscopic cholecystectomy uses several (usually 4) small incisions in the abdomen to allow the insertion of operating ports, small cylindrical tubes approximately 5 to 10 mm in diameter, through which surgical instruments are placed into the abdominal cavity. The laparoscope, an instrument with a video camera and light source at the end, illuminates the abdominal cavity and sends a magnified image from inside the abdomen to a video screen, giving the surgeon a clear view of the organs and tissues, the cystic duct and cystic artery are identified and dissected, then ligated with clips and cut in order to remove the gallbladder. The gallbladder is then removed through one of the ports.
As of 2008, 90% of cholecystectomies in the United States were done laparoscopically. Laparoscopic surgery is thought to have fewer complications, shorter hospital stay, and quicker recovery than open cholecystectomy.
Single incision laparoscopic surgery (SILS) or laparoendoscopic single site surgery (LESS) is a technique in which a single incision is made through the navel, instead of the 3-4 four small different incisions used in standard laparoscopy. There appears to be a cosmetic benefit over conventional four-hole laparoscopic cholecystectomy, and no advantage in postoperative pain and hospital stay compared with standard laparascopic procedures. There is no scientific consensus regarding risk for bile duct injury with SILS versus traditional laparoscopic cholecystectomy.
Natural orifice transluminal
Natural orifice transluminal endoscopic surgery (NOTES) is an experimental technique where the laparoscope is inserted through natural orifices and internal incisions, rather than skin incisions, to access to the abdominal cavity, this offers the potential to eliminate visible scars. Since 2007, cholecystectomy by NOTES has been performed anecdotally via transgastric and transvaginal routes, as of 2009 the risk of gastrointestinal leak, difficulty visualizing the abdominal cavity and other technical limitations limited further adoption of NOTES for cholecystectomy.
In open cholecystectomy, a surgical incision of around 8 to 12 cm is made below the edge of the right rib cage and the gallbladder is removed through this large opening, typically using electrocautery. Open cholecystectomy is often done if difficulties arise during a laparascopic cholecystecomy, for example, the patient has unusual anatomy, the surgeon cannot see well enough through the camera, or the patient is found to have cancer, it can also done if the patient has severe cholecystitis, emphysematous gallbladder, fistulization of gallbladder and gallstone ileus, cholangitis, cirrhosis or portal hypertension, and blood dyscrasias.
After removal, the gallbladder should be sent for pathological examination to confirm the diagnosis and look for any incidental cancer. Incidental cancer of the gallbladder is found in approximately 1% of cholecystectomies.:1019 If cancer is present in the gallbladder, it's usually necessary to re-operate to remove parts of the liver and lymph nodes and test them for additional cancer.
After surgery, most patients are admitted to the hospital for routine monitoring, for uncomplicated laparoscopic cholecystectomies, people may be discharged on the day of surgery after adequate control of pain and nausea. Patients who were high-risk, those who required emergency surgery, and or those undergoing open cholecystectomy usually need to stay in the hospital several days after surgery.
In 95% of people undergoing cholecystectomy as treatment for simple biliary colic, removing the gallbladder completely resolves their symptoms.
Up to 10% of people who undergo cholecystectomy develop a condition called postcholecystectomy syndrome. Symptoms are typically similar to the pain and discomfort of biliary colic with persistent pain in the upper right abdomen and commonly include gastrointestinal distress (dyspepsia).
Some people following cholecystectomy may develop diarrhea. The cause is unclear, but is presumed to be due to disturbances in the biliary system that speed up enterohepatic recycling of bile salts, the terminal ileum, the portion of the intestine where these salts are normally reabsorbed, becomes overwhelmed, doesn't absorb everything, and the person develops diarrhea. Most cases resolve within weeks or a few months, though in rare cases the condition can last for years, it can be controlled with medication such as cholestyramine.[medical citation needed]
It is generally safe for pregnant women to undergo laparoscopic cholecystectomy during any trimester of pregnancy. Early elective surgery is recommended for women with symptomatic gallstones to decrease the risk of spontaneous abortion and pre-term delivery. Without cholecystectomy, more than half of such women will have recurrent symptoms during their pregnancy, and nearly one in four will develop a complication, such as acute cholecystitis, that requires urgent surgery. Acute cholecystitis is the second most common cause of acute abdomen in pregnant women after appendectomy.
Porcelain gallbladder (PGB), a condition where the gallbladder wall shows calcification on imaging tests, was previously considered a reason to remove the gallbladder because it was thought that people with this condition had a high risk of developing gallbladder cancer. However, recent studies have shown that there is no strong association between gallbladder cancer and porcelain gallbladder, and that PGB alone is not a strong enough indication for a prophylactic cholecystectomy.
Alternatives to surgery
There are several alternatives to cholecystectomy for people who do not want surgery, or in whom the benefits of surgery would outweigh the risks.
Conservative management for biliary colic involves a "watch and wait" approach--treating symptoms as-needed with oral medications. Experts agree that this is the preferred treatment for people with gallstones but no symptoms. Conservative management may also be appropriate for people with mild biliary colic, as the pain from colic can be managed with pain medications like NSAIDS (ex: ketorolac) or opioids.
Conservative management for acute cholecystitis involves treating the infection without surgery, it is usually only considered in patients at very high risk for surgery or other interventions listed below. It consists of treatment with intravenous antibiotics and fluids.
ERCP, short for endoscopic retrograde cholangiopancreatography, is an endoscopic procedure that can remove gallstones or prevent blockages by widening parts of the bile duct where gallstones frequently get stuck. ERCP is often used to retrieve stones stuck in the common bile duct in patients with gallstone pancreatitis or cholangitis; in this procedure, an endoscope, or small, long thin tube with a camera on the end, is passed through the mouth and down the throat. The doctor advances the camera through the stomach and into the first part of the small intestine to reach the opening of the bile duct, the doctor can inject a special, radiopaque dye through the endoscope into the bile duct to see stones or other blockages on x-ray. ERCP does not require general anaesthesia and can be done outside of the operating room. While ERCP can be used to remove a specific stone that is causing a blockage to allow drainage, it cannot remove all stones in the gallbladder. Thus, it is not considered a definitive treatment and people with recurrent complications from stones will still likely need a cholecystectomy.
Cholecystostomy is the drainage of the gallbladder via insertion of a small tube through the abdominal wall. This is usually done using guidance from imaging scans to find the right place to insert the tube. Cholecystostomy can be used for people who need immediate drainage of the gallbladder but have a high risk of complications from surgery under general anaesthesia, such as elderly people and those with co-existing illnesses. Draining pus and infected material through the tube reduces inflammation in and around the gallbladder, it can be a lifesaving procedure, without requiring that the person undergo emergency surgery.
The procedure does come with significant risks and complications -- in one retrospective study of patients who received percutaneous cholecystostomy for acute cholecystitis, 44% developed choledocholithiasis (one or more stones stuck in the common bile duct), 27% had tube dislodgment, and 23% developed postoperative abscess.
For some people, drainage with cholecystostomy is enough and they don't need to have the gallbladder removed later, for others, percutaneous cholecystostomy allows them to improve enough in the short term that they can get surgery at a later time. There is no clear evidence one way or another to indicate that surgical removal after cholecystostomy is best for high-risk surgical patients with acute cholecystitis.
About 600,000 people receive a cholecystectomy in the United States each year.:855
In a study of Medicaid-covered and uninsured U.S. hospital stays in 2012, cholecystectomy was the most common operating room procedure.
Carl Langenbuch performed the first successful cholecystectomy at the Lazarus hospital in Berlin on July 15, 1882. Before this, surgical therapy for symptomatic gallstones was limited to cholecystostomy, or gallstone removal. Langenbuch's rationale for developing the new technique stemmed from 17th century studies in dogs that demonstrated the gallbladder to be nonessential and medical opinion among his colleagues that gallstones formed in the gallbladder, although the technique was initially controversial, cholecystecomy became established as a lower mortality procedure than cholecystostomy by the 20th century.
Erich Mühe performed the first laparoscopic cholecystectomy on September 12, 1985 in Böblingen, Germany. Mühe was inspired to develop a technique for laparascopic cholecystectomy by the first laparascopic appendectomy, performed by gynecologist Kurt Semm in 1980. He subsequently designed an optical laparoscope with a working channel large enough to fit a distended gallbladder. Mühe presented his technique to the Congress of the German Surgical Society in 1986, claiming reduced postoperative pain and shorter hospitalization, his work was met with strong resistance by the German surgical establishment and he had difficulty communicating it in English. It was consequently ignored. Mühe's work was further disparaged in 1987, when he was charged with manslaughter for a postoperative patient death that was mistakenly attributed to his innovative technique, he was exonerated in 1990 after further investigation. His pioneering work was eventually recognized by the German Surgical Society Congress in 1992.
Philippe Mouret performed laparascopic cholecystectomy on March 17, 1987 in Lyon, France, his technique was rapidly adopted and improved in France. It was subsequently introduced to the rest of the world over the next three years. Driven by popularity among patients, the laparascopic technique became preferred over open surgery and noninvasive treatments for gallstones.
"Operation Brochures for Patients: Cholecystectomy". American College of Surgeons.
- Abraham S, Rivero HG, Erlikh IV, Griffith LF, Kondamudi VK (May 2014). "Surgical and nonsurgical management of gallstones". American Family Physician. 89 (10): 795–802. PMID 24866215.
- "Characteristics of Operating Room Procedures in U.S. Hospitals, 2011 - Statistical Brief #170". www.hcup-us.ahrq.gov. Retrieved 2018-01-24.
- Mulholland MW, Lillemoe KD, Doherty GM, Upchurch GR, Alam HB, Pawlik TM. Greenfield's surgery : scientific principles & practice (Sixth ed.). Philadelphia. ISBN 978-1-4698-9001-2. OCLC 933274207.
- Jaunoo SS, Mohandas S, Almond LM (2010). "Postcholecystectomy syndrome (PCS)". International Journal of Surgery. 8 (1): 15–7. doi:10.1016/j.ijsu.2009.10.008. PMID 19857610.
- "The National Institutes of Health (NIH) Consensus Development Program: Gallstones and Laparoscopic Cholecystectomy". consensus.nih.gov. Retrieved 2018-03-20.
- Townsend CM, Evers BM, Mattox KL, Beauchamp RD (June 2016). Sabiston textbook of surgery : the biological basis of modern surgical practice (20th ed.). Philadelphia, PA. ISBN 978-0-323-29987-9. OCLC 951748294.
- Agresta F, Campanile FC, Vettoretto N, Silecchia G, Bergamini C, Maida P, Lombari P, Narilli P, Marchi D, Carrara A, Esposito MG, Fiume S, Miranda G, Barlera S, Davoli M (May 2015). "Laparoscopic cholecystectomy: consensus conference-based guidelines". Langenbeck's Archives of Surgery. 400 (4): 429–53. doi:10.1007/s00423-015-1300-4. PMID 25850631.
- Doherty GM (2015). Doherty GM, ed. CURRENT Diagnosis & Treatment: Surgery (14 ed.). New York, NY: McGraw-Hill Education.
- "Gallstones". NIDDK. November 2013. Archived from the original on 28 July 2016. Retrieved 27 July 2016.
- "Gallstone Disease: Diagnosis and Management of Cholelithiasis, Cholecystitis and Choledocholithiasis. Clinical Guideline 188". October 2014. PMID 25473723.
- Velasco JM (October 2015). Essential surgical procedures. Philadelphia, PA. ISBN 978-0-323-37567-2. OCLC 949278311.
- Goldman L (2011). Goldman's Cecil Medicine (24th ed.). Philadelphia: Elsevier Saunders. ISBN 978-1-4377-2788-3.
- Kimura Y, Takada T, Strasberg SM, Pitt HA, Gouma DJ, Garden OJ, Büchler MW, Windsor JA, Mayumi T, Yoshida M, Miura F, Higuchi R, Gabata T, Hata J, Gomi H, Dervenis C, Lau WY, Belli G, Kim MH, Hilvano SC, Yamashita Y (January 2013). "TG13 current terminology, etiology, and epidemiology of acute cholangitis and cholecystitis". Journal of Hepato-Biliary-Pancreatic Sciences. 20 (1): 8–23. doi:10.1007/s00534-012-0564-0. PMID 23307004.
- Kimura Y, Takada T, Kawarada Y, Nimura Y, Hirata K, Sekimoto M, Yoshida M, Mayumi T, Wada K, Miura F, Yasuda H, Yamashita Y, Nagino M, Hirota M, Tanaka A, Tsuyuguchi T, Strasberg SM, Gadacz TR (2007). "Definitions, pathophysiology, and epidemiology of acute cholangitis and cholecystitis: Tokyo Guidelines". Journal of Hepato-Biliary-Pancreatic Surgery. 14 (1): 15–26. doi:10.1007/s00534-006-1152-y. PMC . PMID 17252293.
- "Treatment of Gallstones and Gallbladder Disease". Society for Surgery of the Alimentary Tract. Retrieved 2018-03-27.
- Abbasoğlu O, Tekant Y, Alper A, Aydın Ü, Balık A, Bostancı B, Coker A, Doğanay M, Gündoğdu H, Hamaloğlu E, Kapan M, Karademir S, Karayalçın K, Kılıçturgay S, Şare M, Tümer AR, Yağcı G (2016). "Prevention and acute management of biliary injuries during laparoscopic cholecystectomy: Expert consensus statement". Ulusal Cerrahi Dergisi. 32 (4): 300–305. doi:10.5152/UCD.2016.3683. PMC . PMID 28149133.
- Stewart L (April 2014). "Iatrogenic biliary injuries: identification, classification, and management". The Surgical Clinics of North America. 94 (2): 297–310. doi:10.1016/j.suc.2014.01.008. PMID 24679422.
- Pucher PH, Brunt LM, Davies N, Linsk A, Munshi A, Rodriguez HA, Fingerhut A, Fanelli RD, Asbun H, Aggarwal R (March 2018). "Outcome trends and safety measures after 30 years of laparoscopic cholecystectomy: a systematic review and pooled data analysis". Surgical Endoscopy. doi:10.1007/s00464-017-5974-2. PMID 29556977.
- Siiki A, Rinta-Kiikka I, Sand J, Laukkarinen J (May 2015). "Biodegradable biliary stent in the endoscopic treatment of cystic duct leak after cholecystectomy: the first case report and review of literature". Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A. 25 (5): 419–22. doi:10.1089/lap.2015.0068. PMID 25853929.
- Malik AM, Laghari AA, Talpur AH, Khan A (October 2008). "Iatrogenic biliary injuries during laparoscopic cholecystectomy. A continuing threat". International Journal of Surgery. 6 (5): 392–5. doi:10.1016/j.ijsu.2008.07.005. PMID 18823829.
- Brunicardi FC, Andersen DK, Dunn DL, Hunter JG, Matthews JB, Pollock RE, Billiar TR (2014). Schwartz's principles of surgery (Tenth ed.). ISBN 978-0-07-179674-3.
- Sanabria A, Dominguez LC, Valdivieso E, Gomez G (December 2010). "Antibiotic prophylaxis for patients undergoing elective laparoscopic cholecystectomy". The Cochrane Database of Systematic Reviews (12): CD005265. doi:10.1002/14651858.CD005265.pub2. PMID 21154360.
- Overby DW, Apelgren KN, Richardson W, Fanelli R (October 2010). "SAGES guidelines for the clinical application of laparoscopic biliary tract surgery". Surgical Endoscopy. 24 (10): 2368–86. doi:10.1007/s00464-010-1268-7. PMID 20706739.
- Shackelford's surgery of the alimentary tract. Yeo, Charles J., (Eighth edition ed.). Philadelphia, PA. 2018. ISBN 0323402321. OCLC 1003489504.
- Ingraham AM, Cohen ME, Ko CY, Hall BL (August 2010). "A current profile and assessment of north american cholecystectomy: results from the american college of surgeons national surgical quality improvement program". Journal of the American College of Surgeons. 211 (2): 176–86. doi:10.1016/j.jamcollsurg.2010.04.003. PMID 20670855.
- Yamashita Y, Takada T, Kawarada Y, Nimura Y, Hirota M, Miura F, Mayumi T, Yoshida M, Strasberg S, Pitt HA, de Santibanes E, Belghiti J, Büchler MW, Gouma DJ, Fan ST, Hilvano SC, Lau JW, Kim SW, Belli G, Windsor JA, Liau KH, Sachakul V (January 2007). "Surgical treatment of patients with acute cholecystitis: Tokyo Guidelines". Journal of Hepato-Biliary-Pancreatic Surgery. 14 (1): 91–7. doi:10.1007/s00534-006-1161-x. PMC . PMID 17252302.
- Lirici MM, Tierno SM, Ponzano C (October 2016). "Single-incision laparoscopic cholecystectomy: does it work? A systematic review". Surgical Endoscopy. 30 (10): 4389–99. doi:10.1007/s00464-016-4757-5. PMID 26895901.
- Gaillard M, Tranchart H, Lainas P, Dagher I (October 2015). "New minimally invasive approaches for cholecystectomy: Review of literature". World Journal of Gastrointestinal Surgery. 7 (10): 243–8. doi:10.4240/wjgs.v7.i10.243. PMID 26523212.
- Chamberlain RS, Sakpal SV (September 2009). "A comprehensive review of single-incision laparoscopic surgery (SILS) and natural orifice transluminal endoscopic surgery (NOTES) techniques for cholecystectomy". Journal of Gastrointestinal Surgery. 13 (9): 1733–40. doi:10.1007/s11605-009-0902-y. PMID 19412642.
- Kapoor VK (March 2001). "Incidental gallbladder cancer". The American Journal of Gastroenterology. 96 (3): 627–9. doi:10.1111/j.1572-0241.2001.03597.x. PMID 11280526.
- Gurusamy KS, Rossi M, Davidson BR (August 2013). "Percutaneous cholecystostomy for high-risk surgical patients with acute calculous cholecystitis". The Cochrane Database of Systematic Reviews (8): CD007088. doi:10.1002/14651858.CD007088.pub2. PMID 23939652.
- "ERCP: MedlinePlus Medical Encyclopedia". medlineplus.gov. Retrieved 2018-03-19.
- Furtado R, Le Page P, Dunn G, Falk GL (February 2016). "High rate of common bile duct stones and postoperative abscess following percutaneous cholecystostomy". Annals of the Royal College of Surgeons of England. 98 (2): 102–6. doi:10.1308/rcsann.2016.0004. PMC . PMID 26741665.
- Lopez-Gonzalez L, Pickens GT, Washington R, Weiss AJ (October 2014). "Characteristics of Medicaid and Uninsured Hospitalizations, 2012". HCUP Statistical Brief #183. Rockville, MD: Agency for Healthcare Research and Quality.
- Jarnagin WR, Belghiti J, Blumgart LH (2012). Blumgart's surgery of the liver, biliary tract, and pancreas (5th ed.). Philadelphia: Elsevier Saunders. p. 6. ISBN 978-1-4557-4606-4.
- Reynolds, Walker Jr. (2001). "The First Laparoscopic Cholecystectomy". Journal of the Society of Laparoendoscopic Surgeons. 5 (1): 89–94.
- Polychronidis A, Laftsidis P, Bounovas A, Simopoulos C (2008). "Twenty years of laparoscopic cholecystectomy: Philippe Mouret--March 17, 1987". Jsls. 12 (1): 109–11. PMID 18402752.
- Litynski GS (1998). "Erich Mühe and the rejection of laparoscopic cholecystectomy (1985): a surgeon ahead of his time". Jsls. 2 (4): 341–6. PMID 10036125.
- Stern V (10 June 2013). "The first Lap Chole in Europe: A 'Criminal' Is Vindicated". General Surgery News. Retrieved 4 October 2017.
- Coccolini F, Catena F, Pisano M, Gheza F, Fagiuoli S, Di Saverio S, Leandro G, Montori G, Ceresoli M, Corbella D, Sartelli M, Sugrue M, Ansaloni L (June 2015). "Open versus laparoscopic cholecystectomy in acute cholecystitis. Systematic review and meta-analysis". International Journal of Surgery. 18: 196–204. doi:10.1016/j.ijsu.2015.04.083. PMID 25958296.
- Laparoscopic Cholecystectomy : an Evidence-based Guide. Agresta, Ferdinando,, Campanile, Fabio Cesare,, Vettoretto, Nereo,. Cham [Switzerland]. 2014. ISBN 9783319054070. OCLC 880422516.