Cingestol

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Cingestol
Cingestol.svg
Clinical data
Trade names Lutisan
Synonyms 19-Nor-17α-pregn-5-en-20-yn-17β-ol; O.V. 28[1][2]
Routes of
administration
Oral
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
Formula C20H28O
Molar mass 284.43572 g/mol
3D model (JSmol)

Cingestol (INN, USAN) (former tentative brand name Lutisan),[3] also known as 17α-ethynylestr-5-en-17β-ol,[4] is a steroidal progestin of the 19-nortestosterone group[5][6] that was never marketed.[7] It was synthesized in 1969[7] and was developed in the 1970s by Organon as a low-dose, progestogen-only contraceptive,[8][9][10][11] but in 1984, was still described as "under investigation".[12] The drug is an isomer of lynestrenol with the double bond between C5 and C6.[1]

See also[edit]

References[edit]

  1. ^ a b M. Tausk (1975). Pharmacology of hormones. Thieme. p. 126,129. ISBN 978-3-13-518901-7. 
  2. ^ Concours médical. 1976. p. 1083. 
  3. ^ Registry of Toxic Effects of Chemical Substances. National Institute for Occupational Safety and Health. 1987. p. 2995. 
  4. ^ Janet Brotherton (1976). Sex hormone pharmacology. Academic Press. p. 12. ISBN 978-0-12-137250-7. 
  5. ^ Andrejus Korolkovas (16 August 1988). Essentials of Medicinal Chemistry. Wiley. ISBN 978-0-471-88356-2. 
  6. ^ WHO Technical Report Series. World Health Organization. 1981. p. 75. 
  7. ^ a b J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 279–. ISBN 978-1-4757-2085-3. 
  8. ^ Amnuay Tapingkae (1974). Directory of selected scholars and researchers in Southeast Asia. Regional Institute of Higher Education and Development. p. 687. 
  9. ^ Michael H. Briggs; Maxine Briggs (1976). Biochemical contraception: prospects for human development. Academic Press. p. 283. ISBN 978-0-12-134640-9. 
  10. ^ Aref I, Hefnawi F, Kandil O, Aziz MT (1973). "Effect of minipills on physiologic responses of human cervical mucus, endometrium, and ovary". Fertil. Steril. 24 (8): 578–83. doi:10.1016/s0015-0282(16)39850-8. PMID 4124151. 
  11. ^ Kićović PM, Kovacević S, Djokic LJ, Milojević S, Janoskov J, Behlilović B, Jeremić N (1974). "Clinical evaluation of a new low dose progestagen-only contraceptive containing cingestol". Int. J. Fertil. 19 (3): 171–5. PMID 4375129. 
  12. ^ Windsor Cooper Cutting; T. Z. Csáky; Byron A. Barnes (1984). Cutting's Handbook of Pharmacology: The Actions and Uses of Drugs. Appleton-Century-Crofts. p. 439. ISBN 978-0-8385-1418-4.