POU domain, class 1, transcription factor 1 known as POU1F1, is a transcription factor for growth hormone. PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development; the POU family is so named because the first 3 members identified were PIT1 and OCT1 of mammals, Unc-86 of C. elegans. PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone and prolactin. PIT1 is important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit by thyrotropin-releasing hormone and cyclic AMP. Pituitary-specific positive transcription factor 1 has been shown to interact with GATA2 and PITX1. PIT1+protein,+human at the US National Library of Medicine Medical Subject Headings Transcription+Factor+Pit-1 at the US National Library of Medicine Medical Subject Headings
The 2012 Marion Blue Racers season was the 2nd season for the United Indoor Football League franchise. On July 5, 2011, the Blue Racers announced they were leaving the CIFL to join the Ultimate Indoor Football League; the Blue Racers were added as a member of the Northern Conference, re-uniting with, their arch-rivals, the Cincinnati Commandos. On August 17, 2011, Lorenzo Styles was named the 3rd head coach in franchise history. In February, team CEO and General Manager, LaMonte Coleman, took a coaching position with the Pittsburgh Power of the Arena Football League; the following day, Ryan Sawyer was named the team's interim general manager while Coleman was coaching in Pittsburgh. On March 30, 2012, Styles resigned as the head coach of the Blue Racers after compiling a 3-1 record, citing personal reason as the reason for his resignation. Offensive Coordinator Marc Huddleston, took over as the team's head coach; the team remained a strong pipeline for the Pittsburgh Power, as both the team's kickers, Trey Kramer and Seth Burkholder, signed with the team.
The Blue Racers finished the season with a 7–4 record, earning the 3rd seed in the UIFL North playoff. The team traveled to play the second seeded Erie Explosion, where the game was played at a high school field, where the team had built walls for the playing field, it is the first time. The Explosion went on to defeat the Blue Racers 56–47, after the Blue Racers had led 22–0 early in the game. Key: Win Tie Loss Bye y - clinched regular-season title x - clinched playoff spot
Charlotte Wilhelmine Christiane Marie of Hesse-Darmstadt, was by marriage Duchess of Mecklenburg-Strelitz. Charlotte was a daughter of Prince George William of Hesse-Darmstadt from his marriage to Countess Maria Louise Albertine of Leiningen-Falkenburg-Dagsburg, daughter of Count Christian Karl Reinhard of Leiningen-Dachsburg-Falkenburg-Heidesheim; the princess was first engaged with the hereditary prince Peter Frederick William of Oldenburg, but the engagement was dissolved again as a result of the onset of Peter's mental illness. Charlotte married Charles of Mecklenburg-Strelitz, on 28 September 1784 in Darmstadt, he was married to Charlotte's older sister Friederike, who had died in childbirth. She thus became stepmother for her sister's five surviving children - nephews; the couple lived in Hanover, where Charles served as Governor-General for his brother-in-law, King George. Charlotte died after the birth of her only child, a year after their marriage. Charles resigned from his post in Hanover and moved to Charlotte's mother in Darmstadt, who took care of his children.
Her only child from her marriage to Charles was: Charles and President of the Prussian State Council Carl Friedrich Günther: Anecdotes, character descriptions and memoirs from the Hessian area... p. 172 Political Journal, p. 1274 Luise Schorn-Schütte: Queen Louise, p. 12
Lorenzo Dechalus, known professionally as Lord Jamar, is an American rapper, record producer and social commentator. He is a member of the hip hop group Brand Nubian, which formed in 1989. Jamar is a frequent guest on VladTV, where he has drawn attention for his comments on social issues such as racism and homophobia. Jamar began his career as a member of Brand Nubian, whose 1990 album One for All is regarded as one of the greatest hip hop albums of all time; the group has released a total of six albums. As an actor, he is best known for his role of Supreme Allah on the TV series Oz, he has appeared on Law & Order: Special Victims Unit, Third Watch, The Sopranos. He has done production work for artists such as Dead Prez, whom he discovered, Shaka Amazulu the 7th and Tom Browne, he released his debut solo album The 5% Album on June 27, 2006. Like his onscreen character on Oz, Jamar is a member of the Nation of Earths. Jamar co-hosts a podcast, Yanadameen Godcast, with fellow rapper Rah Digga. Jamar garnered controversy after releasing a diss track towards Kanye West on February 4, 2013 titled "Lift Up Your Skirt," and stated that "gay has no place in hip-hop", which led to him being characterized by some in the media as homophobic.
Jamar denied the homophobia accusations by tweeting that he "went to a gay wedding of a good friend not long ago". In a September 2013 interview on VladTV, Jamar declared that white rappers were "guests in hip hop", compared Eminem to Macklemore, made further remarks about white rappers and homosexuality. Eminem responded to Jamar with the track "Fall" from his 2018 album Kamikaze. Jamar responded to Eminem on his podcast; the 5% Album Lord Jamar at AllMusic Lord Jamar on IMDb
Barnaby Backwell was the member of Parliament for Bishop's Castle, Shropshire, in 1754. Barnaby Backwell was the second but first surviving son of Tyringham Backwell of Tyringham and Elizabeth, daughter of Sir Francis Child, Lord Mayor of London, he was the grandson of the financier Edward Backwell. Backwell was a partner in the bank of Samuel and Francis Child, said to have an income of £4,000 per annum. In the General election of 1754 he was elected to Parliament for Bishop's Castle, a "rotten borough", where his uncle Samuel Child had been the M. P. until his death in 1753. The borough was under the control of the Walcots. Backwell was classed as a Tory in Dupplin's list of 1754, he died the following October. He had married twice, firstly Margaret, the daughter of Samuel Clarke, a London merchant, secondly Sarah Gibbon, with whom he had a son and 3 daughters, his daughter, Elizabeth Tyringham, married William Praed. Http://www.historytoday.com/bevis-hiller/mysterious-case-elizabeth-canning