Coahoma County is a county located in the U.S. state of Mississippi. As of the 2020 census, the population was 21,390. Its county seat is Clarksdale.

Clarksdale is a city in and the county seat of Coahoma County, Mississippi, United States. It is located along the Sunflower River. Clarksdale is named after John Clark, a settler who founded the city in the mid-19th century when he established a timber mill and business. Clarksdale is in the Mississippi Delta region and is an agricultural and trading center. Many African-American musicians developed the blues here, and took this original American music with them to Chicago and other northern cities during the Great Migration.