Colneleate synthase

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Colneleate synthase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Colneleate synthase (EC, 9-divinyl ether synthase, 9-DES, CYP74D, CYP74D1, CYP74 cytochrome P-450, DES1) is an enzyme with systematic name (8E)-9-((1E,3E)-nona-1,3-dien-1-yloxy)non-8-enoate synthase.[1][2][3][4] This enzyme catalyses the following chemical reaction

(9S,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoate (8E)-9-[(1E,3Z)-nona-1,3-dien-1-yloxy]non-8-enoate + H2O

This enzyme is a heme-thiolate protein (P450).


  1. ^ Stumpe, M.; Kandzia, R.; Gobel, C.; Rosahl, S.; Feussner, I. (2001). "A pathogen-inducible divinyl ether synthase (CYP74D) from elicitor-treated potato suspension cells". FEBS Lett. 507: 371–376. doi:10.1016/s0014-5793(01)03019-8. PMID 11696374. 
  2. ^ Itoh, A.; Howe, G.A. (2001). "Molecular cloning of a divinyl ether synthase. Identification as a CYP74 cytochrome P-450". J. Biol. Chem. 276: 3620–3627. doi:10.1074/jbc.m008964200. PMID 11060314. 
  3. ^ Fammartino, A.; Cardinale, F.; Gobel, C.; Mene-Saffrane, L.; Fournier, J.; Feussner, I.; Esquerre-Tugaye, M.T. (2007). "Characterization of a divinyl ether biosynthetic pathway specifically associated with pathogenesis in tobacco". Plant Physiol. 143: 378–388. doi:10.1104/pp.106.087304. PMC 1761965Freely accessible. PMID 17085514. 
  4. ^ Hamberg, M. (2005). "Hidden stereospecificity in the biosynthesis of divinyl ether fatty acids". FEBS J. 272: 736–743. doi:10.1111/j.1742-4658.2004.04510.x. PMID 15670154. 

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