Combretastatin B-1

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Combretastatin B-1
Combretastatin B-1.PNG
IUPAC name
Other names
Combretastatin B1
3D model (JSmol)
Molar mass 334.36 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Combretastatin B-1 is a combretastatin and a dihydrostilbenoid. It can be found in Combretum caffrum, the Eastern Cape South African bushwillow tree[1] or in Combretum kraussii, the forest bushwillow.[2]

It can be produced by selective hydrogenation of Combretastatin A-1.[1]

It is a potent inhibitor of microtubule assembly in vitro.[1]


  1. ^ a b c Pettit, G. R.; Singh, S. B.; Niven, M. L.; Hamel, E.; Schmidt, J. M. (1987). "Isolation, Structure, and Synthesis of Combretastatins A-1 and B-1, Potent New Inhibitors of Microtubule Assembly, Derived from Combretum caffrum". Journal of Natural Products. 50 (1): 119–131. doi:10.1021/np50049a016. PMID 3598594. 
  2. ^ Uteroactive constituents from Combretum kraussii. Bridget K Brookes, Olga V Doudoukina, Lynn C Katsoulis and Joy H D Veale, South African Journal of Chemistry, Dec 99, Vol. 52, Issue 4, page 127 (abstract)