Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids and mineralocorticoids, are involved in a wide range of physiological processes, including stress response, immune response, regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, behavior; some common occurring steroid hormones are cortisol, corticosterone and aldosterone. The main corticosteroids produced by the adrenal cortex are aldosterone. Glucocorticoids such as cortisol affect carbohydrate and protein metabolism, have anti-inflammatory, immunosuppressive, anti-proliferative, vasoconstrictive effects. Anti-inflammatory effects are mediated by blocking the action of inflammatory mediators and inducing anti-inflammatory mediators. Immunosuppressive effects are mediated by suppressing delayed hypersensitivity reactions by direct action on T-lymphocytes. Anti-proliferative effects are mediated by inhibition of epidermal cell turnover.
Vasoconstrictive effects are mediated by inhibiting the action of inflammatory mediators such as histidine. Mineralocorticoids such as aldosterone are involved in the regulation of electrolyte and water balance by modulating ion transport in the epithelial cells of the renal tubules of the kidney. Synthetic pharmaceutical drugs with corticosteroid-like effects are used in a variety of conditions, ranging from brain tumors to skin diseases. Dexamethasone and its derivatives are pure glucocorticoids, while prednisone and its derivatives have some mineralocorticoid action in addition to the glucocorticoid effect. Fludrocortisone is a synthetic mineralocorticoid. Hydrocortisone is used for replacement therapy, e.g. for adrenal insufficiency and congenital adrenal hyperplasia. Medical conditions treated with systemic corticosteroids: Topical formulations are available for the skin, lungs and bowels. Corticosteroids are used supportively to prevent nausea in combination with 5-HT3 antagonists. Typical undesired effects of glucocorticoids present quite uniformly as drug-induced Cushing's syndrome.
Typical mineralocorticoid side-effects are hypertension, steroid induced diabetes mellitus, poor sleep, hypernatremia without causing peripheral edema, metabolic alkalosis and connective tissue weakness. Wound healing or ulcer formation may be inhibited by the immunosuppressive effects. Clinical and experimental evidence indicates that corticosteroids can cause permanent eye damage by inducing central serous retinopathy; this should be borne in mind. There is experimental and clinical evidence that, at least in optic neuritis speed of treatment initiation is important. A variety of steroid medications, from anti-allergy nasal sprays to topical skin creams, to eye drops, to prednisone have been implicated in the development of CSR. Corticosteroids have been used in treating people with traumatic brain injury. A systematic review identified 20 randomised controlled trials and included 12,303 participants compared patients who received corticosteroids with patients who received no treatment; the authors recommended people with traumatic head injury should not be treated with corticosteroids.
Patients' response to inhaled corticosteroids has some basis in genetic variations. Two genes of interest are CHRH1 and TBX21. Both genes display some degree of polymorphic variation in humans, which may explain how some patients respond better to inhaled corticosteroid therapy than others. However, not all asthma patients respond to corticosteroids and large sub groups of asthma patients are corticosteroid resistant.\ Use of corticosteroids has numerous side-effects, some of which may be severe: Severe amebic colitis: Fulminant amebic colitis is associated with high case fatality and can occur in patients infected with the parasite Entamoeba histolytica after exposure to corticosteroid medications. Neuropsychiatric: steroid psychosis, anxiety, depression. Therapeutic doses may cause a feeling of artificial well-being; the neuropsychiatric effects are mediated by sensitization of the body to the actions of adrenaline. Therapeutically, the bulk of corticosteroid dose is given in the morning to mimic the body's diurnal rhythm.
An extensive review is provided by Gumina. Cardiovascular: Corticosteroids can cause sodium retention through a direct action on the kidney, in a manner analogous to the mineralocorticoid aldosterone; this can result in fluid hypertension. Metabolic: Corticosteroids cause a movement of body fat to the face and torso, resulting in "moon face", "buffalo hump", "pot belly" or "beer belly", cause movement of body fat away from the limbs; this has been termed corticosteroid-induced lipodystrophy. Due to the diversion of amino-acids to glucose, they are considered anti-anabolic, long term therapy can cause muscle wasting. Endocrine: By increasing the production of glucose from amino-acid breakdown and opposing the action of insulin, corticosteroid
35 Boys 5 Concepts is an EP by contestants of the South Korean survival show Produce 101 Season 2. It was released online for download on June 3, 2017, by CJ E&M. Produce 101 Season 2 was a South Korean survival show that aired on Mnet from April to June in 2017 where 101 male trainees from various entertainment companies competed to debut in an 11-member boy group which would promote until December 2018. On the 8th and 9th episode, the 35 remaining trainees were split into five teams and given five new songs from different producers, with different genres, they were tasked to perform these songs live in front of total audience of 2000. The nu-disco song "Show Time" was produced by Oh Sung Hwan, ASHTRAY and Kingmaker; the synth pop/funk song "I Know You Know" was produced by Jeff Lewis, nomad, MRey, Hyuk Shin who has worked with many major artists in K-pop industry, including Exo, Shinee, f, Girls' Generation and Teen Top. The Future EDM song "열어줘" was produced by Devine Channel who has composed BTS's Fire and VIXX's Shangri-La.
The hip hop song "Oh Little Girl" was produced by ASSBRASS and Phantom's Kiggen from Brand New Music, the deep house song "Never" was produced by Cube Entertainment's PENTAGON and Triple H. On June 3, 2017, "Never" by Nation's Sons achieved an all-kill on Instiz, charting at #1 on real-time charts of Melon, Bugs and Naver
Anthony Shaquille Brown is an American football cornerback for the Dallas Cowboys of the National Football League. He played college football at Purdue. Brown attended Hillsborough High School, where he was a two-year starter and received second-team All-Hillsborough County honors; as a junior, he tallied 69 tackles, one interception, one pass defensed and 4 receptions for 52 yards. In his last year he was a two-way player, posting 25 tackles, 2 interceptions, 3 passes defensed, 911 rushing yards, 14 rushing touchdowns, 18 receptions for 239 yards and one touchdown, he practiced track. Brown accepted a scholarship from Purdue University, he became a starter as a sophomore, registering 69 tackles, 3 tackles for loss, 3 passes defensed and one forced fumble. The next year, he posted 54 tackles, 5.5 tackles for loss, 1.5 sacks, 10 passes defensed, one fumble recovery. As a senior, he made 4 interceptions and 6 passes defensed. Source: The Dallas Cowboys selected Brown in the sixth round of the 2016 NFL Draft.
Brown was the 27th cornerback drafted in 2016. On May 18, 2016, the Dallas Cowboys signed Brown to a four-year, $2.47 million contract that includes a signing bonus of $134,947. Throughout training camp, Brown competed to be a backup cornerback against Josh Thomas, Isaiah Frey, Dax Swanson, Deji Olatoye. Head coach Jason Garrett named Brown the fourth cornerback on the depth chart to start the regular season, he began the season behind Brandon Carr, Morris Claiborne, Orlando Scandrick. He made his professional regular season debut in the Dallas Cowboys’ season-opener against the New York Giants and made one solo tackle during their 20–19 loss. On September 25, 2016, Brown earned his first career start in place of Orlando Scandrick, inactive due to a hamstring injury. Brown finished the Cowboys’ 31–17 victory against the Chicago Bears with four combined tackles. In Week 6, he collected a season-high 11 combined tackles during a 30–16 win at the Green Bay Packers. Brown began to see extended play beginning in Week 9 of the season after Morris Claiborne sustained a groin injury the previous week.
On December 11, 2016, Brown recorded two solo tackles, broke up a pass, made his first career interception as the Cowboys lost 10–7 at the New York Giants in Week 14. Brown intercepted a pass attempt by Giants’ quarterback Eli Manning, intended for wide receiver Victor Cruz in the fourth quarter, he finished his rookie season in 2016 with 55 combined tackles, eight pass deflections, one interception in 16 games and nine starts. The Dallas Cowboys earned a first round bye. On January 15, 2017, Brown recorded one tackle during a 34–31 loss to the Green Bay Packers in the NFC Divisional Round. Brown entered training camp as a possible candidate to win the role as a starting cornerback after Brandon Carr departed in free agency, he competed against Orlando Scandrick, Nolan Carroll, Chidobe Awuzie, Jourdan Lewis. Head coach Jason Garrett named Brown the fourth cornerback on the depth chart to begin the regular season, behind Orlando Scandrick, Nolan Carroll, Chidobe Awuzie, he appeared in the Dallas Cowboys’ season-opener against the New York Giants on Sunday Night Football and recorded one solo tackle, broke up a pass, intercepted a pass by Giants’ quarterback Eli Manning in the fourth quarter of their 19–3 victory.
The following week, he collected a season-high seven solo tackles during a 42–17 loss at the Denver Broncos in Week 2. He earned his first start of the season in Week 2 after Nolan Carroll suffered a concussion and was subsequently released on October 11, 2017. Brown started the next ten games, but was benched for Chidobe Awuzie in Week 13 and remained a backup for the last five games of the regular season. On December 31, 2017, Brown recorded six combined tackles, deflected a pass, made his first career sack in the Cowboys’ 6–0 win at the Philadelphia Eagles in Week 17. Brown sacked Eagles’ backup quarterback Nate Sudfeld for a 14-yard loss in the third quarter. Brown finished the 2017 NFL season with 56 combined tackles, 11 pass deflections, two interceptions, a sack in 16 games and ten starts. During training camp, Brown competed to be a starting cornerback against Byron Jones after Jones was moved from free safety to cornerback. Head coach Jason Garrett named Brown the third cornerback and first-team nickelback on the Cowboys’ depth chart to begin the regular season.
He was listed on the depth chart behind Byron Jones. Brown entered the 2019 season as the third cornerback on the depth chart behind Byron Jones and Chidobe Awuzie. In Week 11, Brown was ruled out the rest of the season, he finished the season playing in nine games with four starts, recording 17 tackles and five passes defensed. Dallas Cowboys bio Purdue bio
Henry Cockburn was a 15th-century Scottish prelate. Between 1461 and 1476, he was the Bishop of Ross. On 23 March 1461 he received papal provision to the bishopric of Ross vacant by the death of Thomas de Tulloch, he was consecrated sometime between 19 October 1463, when his name occurred in a Dunfermline Abbey document as bishop "elect and confirmed", 16 August 1464, when he witnessed a royal charter as consecrated bishop. He was at Arbroath Abbey when Richard Guthrie was elected Abbot of Arbroath on 3 November 1470. Bishop Cockburn was sent as part of an embassy to the Kingdom of England in 1473, he was in attendance at the Edinburgh parliament of 15 July 1476, witnessed a royal charter on 22 July. The episcopal see of Ross was vacant by 20 August, suggesting that Bishop Cockburn had died at some stage between 22 July or 20 August and although resignation or demotion is a possibility, there is no evidence pointing to such a unusual and notable occurrence. Henry Cockburn, as a cleric and prelate, was forbidden from marriage, but he is known to have had at least one son, John Cockburn.
Dowden, The Bishops of Scotland, ed. J. Maitland Thomson, Robert, An Historical Catalogue of the Scottish Bishops: Down to the Year 1688, Watt, D. E. R. Fasti Ecclesiae Scotinanae Medii Aevi ad annum 1638, 2nd Draft
Wall Street is a station on the IRT Lexington Avenue Line of the New York City Subway, located at the intersection of Broadway and Wall Street. It is served by the 4 train at the 5 train at all times except late nights; this station opened on June 12, 1905, as a one-stop extension of the original subway from Fulton Street. On January 6, 1994, Automated Fare Collection turnstiles went into service at this station, at the Whitehall Street station. In 1995, as a result of service reductions, the MTA was considering permanently closing one of the two Wall Street stations, as well as two other stations citywide, due to their proximity to each other. Either the IRT Broadway–Seventh Avenue Line station or the IRT Lexington Avenue Line station would have been closed. Wall Street is an underground, two-tracked station, with two side platforms that are offset from one another; the standard IRT name tablet mosaics are original as well as the fancy ceiling accents and the iron pillars. On the southbound platform are a disused wooden token booth, wooden restroom doors, an antique wooden ticket chopper.
The walls on the platforms are clad in pink stone at the bottom, followed by white tiles, the name of the station in white letters and blue mosaics, a terracotta frieze featuring a New Amsterdam step-gabled house with the palisade wall in front of it which gave Wall Street its name. There are south ends of the southbound platform. On the southbound side, the west side of Broadway, street exits are built into the facade of 71 Broadway, south of Rector Street, one on either side of the main entrance. North of Rector Street there are two staircases in front of the Trinity Churchyard fence, each with a faux kiosk, or canopy. At the north end of the station a street exit is built into the side of 111 Broadway, it has an opulent brass-toned banner proclaiming "Subway Entrance" atop the entrance, half a flight below ground. The exit has a Subway restaurant outside fare control. On the northbound side, three staircases lead to the east side of Broadway near Rector Street; the north end of the platform leads to a tunnel which connects on the left to a crossunder, on the right to a passageway exiting fare control and continuing to a street staircase at Cedar and Nassau Streets, to a connection to the Broad Street station on the BMT Nassau Street Line.
The original white tiles from the early 20th century were walled over with glossy dark blue tiles in the 1970s, with only the name of station allowed to stay. Similar remodeling work was done during that time with 51st Street station on the IRT Lexington Avenue Line, using beige tiles. In 2006, a project to renovate/restore the station back to its original appearance began; as of May 2006, the blue tiles mentioned above had been removed and remnants of the original white tile-work exposed. The condition of the original tiles was fair to poor to missing. All missing tiles were refitted based on original models. Lee Stookey. Subway Ceramics: A History and Iconography. 1994. ISBN 978-0-9635486-1-0 nycsubway.org – IRT East Side Line: Wall Street Wall Street - Rector Street entrance from Google Maps Street View Platforms from Google Maps Street View
"Albuquerque" is the last song of "Weird Al" Yankovic's Running with Scissors album. At 11 minutes and 22 seconds, it is the longest song Yankovic has released on any of his official studio albums. With the exception of the choruses and occasional bridges, the track is a spoken word narration about Yankovic's made-up life in Albuquerque, New Mexico, after winning a first-class one-way airplane ticket to the city. According to Yankovic, the song is in the style of the "hard-driving rock narrative" of artists like The Rugburns, Mojo Nixon and George Thorogood. Yankovic set off to write the lengthy song, considering it as a final track for Running with Scissors; the long meandering story was not expected to be popular and instead Yankovic wanted to compose a song "that's just going to annoy people for 12 minutes", making it feel like an "odyssey" for the listener after making it through to the end. Yankovic described writing the song as "free flowing," writing down a great deal of material he thought would be funny including previous anecdotes he had recorded, trimming it down to form a lengthy "semi-cohesive story."
The lyrics were too long to include in the liner notes for the album, though full lyrics were posted to Yankovic's website. The song starts by Al talking about his childhood with a paranoid mother who force-feeds him sauerkraut until he reaches age "twenty-six and a half". One day while listening to the radio, he hears about a contest in which contestants "guess the number of molecules on Leonard Nimoy's butt", he wins the contest. The grand prize is a first class one-way ticket to Albuquerque. During the flight, three of the engines burn out, causing the plane to crash and explode, killing everyone on board except him, he finds himself crawling, while carrying all of his belongings. He checks into a hotel. Although he asks multiple times who it is, he receives no answer; when he opens the door himself, he's greeted by a "big, fat hermaphrodite with a Flock of Seagulls haircut and only one nostril", who rushes in and grabs his prized possession: his lucky snorkel. The two engage in a fight, only for the man to escape with his snorkel.
He vows to stop at nothing until the mysterious man gets what he deserves, but decides to buy some doughnuts first. Upon driving to the local doughnut shop, he finds that they have run out of everything except for a box of crazed weasels, he purchases the box, only for the weasels inside to bite his face. As he runs around town screaming for help, he runs into a woman named Zelda, who points out the weasels on his face; the two fall in love, buy a house, have children. One night, after Zelda asks him about joining the Columbia Record Club, he freaks out due to his fear of commitment and they break up, never to see each other again. Shortly afterwards he gets his dream job at the Sizzler and makes employee of the month when extinguishing a grease fire using his own face, he tells an anecdote about the time he spotted his Sizzler co-worker Marty trying to carry a big couch up a flight of stairs. He asks if Marty needs help, to which Marty replies sarcastically, "No, I want you to cut off my arms and legs with a chainsaw."
Taking Marty Al complies. Marty points out that his remark was not serious, but Al questions how he was supposed to know; this reminds him of yet another incident in which a man tells him he "hasn't had a bite in three days". He responds by biting his jugular vein, but believes he "just can't take a joke" when he doesn't laugh. At this point, Al loses his train of thought, reveals that the point he was attempting to make was his hatred for sauerkraut, he ends the song by attempting to give advice to the listener, claiming that no matter how hard life is, there's "still a little place called Albuquerque". At the end of the song, faint laughter can be heard in the background; as Yankovic says, "That's Jim West laughing - I thought it would be a good way to end the album. He's cracking up because of the stupid chord he played at the end of the song." Contrary to Yankovic's belief that the song would not be popular, it was one of the best-received songs from the album, Yankovic incorporated the song as an encore to his tours.
When performing this song live, Yankovic has been known to extend the song, by listing off more types of doughnuts, including blueberry, raspberry, loganberry, Halle Berry, old-fashioned doughnuts and Nanaimo bars, as well as Saskatoon berry donuts. When performing this song live in Canada, Al is known to replace the dream job at Sizzler with one at Tim Hortons, a Canadian doughnut shop. During the guitar solo of the third chorus, Yankovic sometimes introduces West eagerly, but West plays "Mary Had a Little Lamb" instead of the real solo. Yankovic acts disappointed, West walks away acting ashamed. List of songs by "Weird Al" Yankovic Shaggy dog story