Cyclazodone

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Cyclazodone
Cyclazodone structure.svg
Clinical data
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
  • In general: legal
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
Formula C12H12N2O2
Molar mass 216.090 g/mol
3D model (JSmol)
Chirality Racemic mixture
 NYesY (what is this?)  (verify)

Cyclazodone is a centrally acting stimulant drug developed by American Cyanamid Company in the 1960s.[1] The drug is related to other drugs such as pemoline and thozalinone. It displayed a favorable therapeutic index and margin of safety than Pemoline and other N-lower-alkyl-substituted Pemoline derivatives.[2]

The patents concluded that Cyclazodone possessed properties efficacious in reducing fatigue and as a potential anorectic.[3] Structural congeners of Pemoline have been described as "excitants with unique properties distinguishing them from the sympathomimetic amines" whilst displaying less stimulatory activity and toxicity compared to amphetamine.[4]

It is a included under the World Anti-Doping Agency prohibited list.[5]

See also[edit]

References[edit]

  1. ^ US Patent 3,321,470 - 5-Arylidene-2Amino-2-Oxazolin-4-Ones
  2. ^ Val De Marne, Don Pierre R. L. Guidicelli, and Henry Najer. 5-Phenyl-2-Cyclopropylamino-4-Oxazolinone. Les Laboratoires Dausse, assignee. Patent US3609159. 28 Sept. 1971.
  3. ^ Val De Marne, Don Pierre R. L. Guidicelli, and Henry Najer. 5-Phenyl-2-Cyclopropylamino-4-Oxazolinone. Les Laboratoires Dausse, assignee. Patent GB1005738A. 29 Sept. 1965
  4. ^ Greenblatt EN, Osterberg AC. Some pharmacologic properties of thozalinone, a new excitant. Toxicol Appl Pharmacol. 1965;7(4):566-78.
  5. ^ World Anti-Doping Agency 2008 Prohibited List[permanent dead link]