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Cyclostomata is a group of agnathans that comprises the living jawless fishes: the lampreys and hagfishes. Both groups have jawless mouths with horny epidermal structures that function as teeth, branchial arches that are internally positioned instead of external as in jawed fishes; the name Cyclostomata means "round mouths". It was named by Joan Crockford Beattie; this taxon is included in the paraphyletic superclass Agnatha, which includes several groups of extinct armored fishes called ostracoderms. Most fossil agnathans, such as galeaspids and osteostracans, are more related to vertebrates with jaws than to cyclostomes. Cyclostomes seem to have split off before the evolution of dentine and bone, which are present in many fossil agnathans, including conodonts. Biologists disagree about; the "vertebrate hypothesis" holds that lampreys are more related to gnathostomes than they are to the hagfish. The "cyclostome hypothesis", on the other hand, holds that lampreys and hagfishes are more related, making cyclostomata monophyletic.

Most studies based on anatomy have supported the vertebrate hypothesis, while most molecular phylogenies have supported the cyclostome hypothesis. There are exceptions in both cases, however. Similarities in the cartilage and muscles of the tongue apparatus provide evidence of sister-group relationship between lampreys and hagfishes, and at least one molecular phylogeny has supported the vertebrate hypothesis. The embryonic development of hagfishes was once held to be drastically different from that of lampreys and gnathostomes, but recent evidence suggests that it is more similar than thought, which may remove an obstacle to the cyclostome hypothesis. There is at present no consensus on the correct topology. Both hagfishes and lampreys for different reasons. In hagfishes the left gonad degenerates during their ontogeny and only the right gonad develops, whereas in lampreys the left and right gonads fuse into one. There are no gonoducts present. Hagfishes have direct development, but lamprey go through a larval stage followed by metamorphosis into a juvenile form.

Lamprey larvae live in freshwater and are called ammocoetes, are the only vertebrates with an endostyle, an organ used for filter feeding, otherwise found only in tunicates and lancelets. During metamorphosis the lamprey endostyle develops into the thyroid gland; the cyclostomata evolved oxygen transport hemoglobins independently from the jawed vertebrates. Hagfishes and lampreys lack a thymus, spleen and sympathetic chain ganglia. Neither species has internal eye muscles and hagfishes lack external eye muscles. Both groups have only a single olfactory organ with a single nostril; the nasal duct opens into the pharynx in hagfishes. The branchial basket is attached to the cranium; the mouth apparatus in hagfishes and adult lampreys has some similarities, but differ from one another. Lampreys have tooth plates on the top of a tongue-like piston cartilage, the hagfish have a fixed cartilagous plate on the floor of its mouth with groves that allows tooth plates to slide backwards and forwards over it like a conveyor belt, are everted as they move over the edge of the plate.

Hagfishes have a keratinous palatine tooth hanging from the roof of the mouth. Unlike jawed vertebrates, which have three semicircular canals in each inner ear, lampreys have only two and hagfishes just one; the semicircular canal of hagfishes contains both stereocilia and a second class of hair cells a derived trait, whereas lampreys and other vertebrates have stereocilia only. Because the inner ear of hagfishes has two forms of sensory ampullae, their single semicircular canal is assumed to be a result of two semicircular canals that have merged into just one; the hagfish blood is isotonic with seawater, while lampreys appears to use the same gill-based mechanisms of osmoregulation as marine teleosts. Yet the same mechanisms are apparent in the mitochondria-rich cells in the gill epithelia of hagfishes, but never develops the ability to regulate the blood's salinity if they are capable of regulating the ionic concentration of Ca and Mg ions, it has been suggested that the hagfish ancestors evolved from an anadromous or freshwater species that has since adapted to saltwater over a long time, resulting in higher electrolyte levels in its blood.

The lamprey intestine has a typhlosole that increases the inner surface like the spiral valve does in some jawed vertebrates. The spiral valve in the latter develops by twisting the whole gut, while the lamprey typhlosole is confined to the mucous membrane of the intestines; the mucous membranes of hagfishes have a primitive typhlosole in the form of permanent zigzag ridges. This trait could be a primitive one, since it is found in some sea squirts such as Ciona; the intestinal epiphelia of lampreys have ciliated cells, which have not been detected in hagfishes. Because ciliated intestines are found in Chondrostei and the early stages of some teleosts, it is considered a primitive condition, lost in hagfishes. Related text and image resources Nelson, Joseph S.. Fishes of the World. John Wiley & Sons, Inc. ISBN 0-471-25031-7

Red Tape (album)

Red Tape is an album by the American southern rock band Atlanta Rhythm Section, released in 1976.. "Jukin" – 3:43 "Mixed Emotions" – 3:20 "Shanghied" – 2:14 "Police! Police!" – 3:11 "Beautiful Dreamers" – 3:26 "Oh What a Feeling" – 2:39 "Free Spirit" – 3:35 "Another Man's Woman" – 9:47 Barry Bailey - guitar Buddy Buie - vocals J. R. Cobb - guitar, background vocals Dean Daughtry - keyboards Paul Goddard - bass guitar Ronnie Hammond - vocals, background vocals Robert Nix - percussion, background vocals Producer: Buddy Buie Engineer: Rodney Mills Album Singles

Patayin sa Sindak si Barbara (1995 film)

Patayin sa Sindak si Barbara is a 1995 Philippine psychological horror film directed by Chito S. Roño and written by Ricardo Lee, it is a remake of the 1974 horror film by Celso Ad. Castillo. Being the loving older sister, Barbara has always been overly indulgent of her little sister Ruth's every whim. Years Barbara meets and falls in love with Nick, mutually smitten with her, but the spoiled Ruth confesses to her older sister that she too is in love with Nick and threatens to kill herself if he does not marry her. So with a heavy heart, Barbara once again passively accommodates Ruth's demands and convinces Nick to court her younger sister instead. In a twisted act of devotion, Nick reluctantly agrees to prove his love for Barbara. After the wedding, Barbara decides to start a new life abroad, to give Nick a chance to fall in love with Ruth and for Barbara to get over her feelings for him, her past comes back to haunt her when Barbara receives news that her younger sister has killed herself and was witnessed by Ruth's only daughter Karen.

Barbara returns to the Philippines to mourn her sister and comfort her unstable niece. But strange events happen upon Barbara's return and she learns the reason surrounding Ruth's mysterious death. Throughout their marriage, Ruth felt that Nick never loved her, but instead still harboured feelings for her sister. In a state of paranoid delusion, she suspects that Nick was having an affair and used his business trips to the United States as an excuse to rendezvous with Barbara. In a jealous rage, she commits suicide and haunts the household and everyone she deemed who have wronged her, it was revealed that since Barbara left her for the US, she indulged herself of everything that can ease her helplessness which includes witchcraft and spiritual medium sessions. Through this she learned that after death she can return to the world of the living on a limited time to haunt and exact revenge on anyone she wants. Maestra Beatriz, whom Barbara sought advise and was responsible for teaching Ruth black magic offered help and have tried to make contact with her tormented soul via spiritual session together with Barbara and her maid.

During this session Ruth manages to kill the old woman. Through an act of sacrifice, Maestra Beatriz manages to drive away Ruth's spirit. All seems well, until Barbara and Nick learned that what happened during Barbara's encounter with Ruth's spirit was only temporary and now, since it was the 9th day of Ruth's passing, she now have grown more powerful and with the help of evil spirits whom she now have given purpose. Ruth appears and manages to convince Barbara to join her in the world of the tormented souls until Nick arrives just in time and instead sacrificed himself by holding the physical manifestation of Ruth and plunging both themselves to the fiery pits of hell. Lorna Tolentino as Barbara Dawn Zulueta as Ruth Duarte Tonton Gutierrez as Nick Duarte Antoinette Taus as Karen Duarte Anita Linda as Yaya Benita Amy Austria as Arlene Nonie Buencamino as Bidoy Angie Ferro as Maestra Beatriz Eva Aquino as Sofia Ernie Zarate as Priest Augusto Victa as Lawyer Cris Daluz as Bangkero Mina Ferrer as Dawn's Double The majority of the visual effects used in the film were handled by Cinevideo Arts Philippines.

Digital compositing was handled by Video Post. As part of the projects of the ABS-CBN Film Archives, the movie is one of the classic Filipino films that were digitally restored and remastered in HD. A special screening of the restored HD version of the film was held on April 6, 2016 at the UP Cine Adarna. Patayin Mo Sa Sindak Si Barbara – a 1974 Filipino film Patayin Sa Sindak Si Barbara – a Filipino TV series based on the 1974 film Patayin sa Sindak si Barbara on IMDb

Holme Fen

Holme Fen is a 269.4 hectare biological Site of Special Scientific Interest near Holme in Cambridgeshire. It is a National Nature Reserve and a Nature Conservation Review site, Grade I, it is part of the Great Fen project, which aims to create a 3,700 wetland wildlife area including Holme Fen, Woodwalton Fen and other areas. It is home to a variety of birds, including the Eurasian siskin and Lesser redpoll, around 450 species of fungi. Home Fen is described by Natural England as the finest example of birch woodland in lowland Britain. Part of it was a mere, drained in the nineteenth century, some relict wetland plants survive such as saw sedge and fen wood-rush. Two new lakes have been excavated. Holme Fen Holme Posts, is believed to be the lowest land point in Great Britain at 2.75 metres below sea level. In October 2015, archaeological work to recover a WW2 Spitfire, flown by Pilot Officer Harold Penketh, that crashed into Holme Fen on 22 November 1940, was undertaken. Led by Oxford Archaeology East's project director Stephen Macauley, the teams located and recovered artefacts from the crash.

A film of the excavation was shown at the Great Fen's Countryside Centre, Ramsey Heights on 27 September, 2019. The reserve is open to the public throughout the year. Several footpaths cross the site. Holme Fem is at the south-western edge of the former Whittlesey Mere, drained; the Great Fen Project aims to reconnect Holme Fen with nearby Woodwalton Fen, another vestigial fragment of wild fenland. Holme marks the south-western limit of Stage 2 of the Great Fen Project


Optimizely is an American company that makes customer experience optimization software for other companies. The Optimizely platform technology provides A/B testing tools, in which two versions of a web page can be compared for performance, multivariate testing. Optimizely enables personalization, which may be used for making data-driven decisions; the personalization capability can be used for serving online advertising. The company's headquarters are in San Francisco, California with offices in Amsterdam, Cologne, London, United Kingdom and Sydney, Australia. Optimizely was founded in 2010 by Dan Siroker and Pete Koomen, both of Google. Optimizely completed the Y Combinator seed accelerator program in the winter of 2010. In November 2010, Optimizely closed a US$1.2 million funding round from angel investors. The company became cash flow positive in 2011. In May 2012 Optimizely announced that it had raised new funding from Battery Ventures, GV, InterWest Partners. In April 2013, Optimizely raised $28 million in Series A round funding.

The round was led by Benchmark, with participation from Bain Capital Ventures and Optimizely's existing investors Battery Ventures, InterWest Partners, Google Ventures. Benchmark's Peter Fenton joined Optimizely's board of directors; as part of a larger international expansion plan, Optimizely announced in April 2013 the launch of their platform in nine additional languages: Danish, French, Italian, Portuguese and Swedish. On April 17, Optimizely held its first Opticon user conference, where they announced the launch of their new mobile app A/B testing software. In May 2014, Optimizely raised $57 million in Series B funding; the round was led by Andreessen Horowitz with participation from Benchmark and Bain Capital Ventures. As part of the round, Scott Weiss general partner at Andreessen Horowitz joined Optimizely's board of directors. In October 2015 the company released its second product for mobile and website personalization. In the same month Optimizely raised $58 million in Series C funding, led by Index Ventures, with participation from firms such as Andreessen Horowitz, Bain Capital Ventures, Battery Ventures, Benchmark Capital, Citi Ventures, Danhua Capital, Salesforce Ventures and Tenaya Capital.

As part of the round, Ilya Fushman of Index joined Optimizely's board of directors. On March 10, 2016 Optimizely laid off 40 employees, 10% of the workforce. In September 2016, the company released Optimizely X, with expanded solutions for web experimentation, recommendations, full stack and OTT. In July 2017, Jay Larson replaced Dan Siroker as the company's CEO. Pete Koomen was the company's CTO in 2012. Co-founder Dan Joseph Siroker became the company's Executive Chairman in July 2017. Optimizely's experimentation platform is called Optimizely X, with tools for web experimentation, recommendations, full stack and over-the-top content; the optimization is delivered in a software as a service model. Opticon is a user conference organized by Optimizely focused on web experience optimization; the first Opticon conference was held on April 17, 2014 in San Francisco, where Optimizely announced their mobile A/B testing product. The second Opticon conference was held on June 17 & 18, 2015 in San Francisco, where they announced a new Personalization product.

Marc Andreessen was the keynote speaker. Red Herring Top 100 North America 2013 Finalist Gartner's Cool Vendors in Web Computing 2013 Digital Analytics Association New Technology of the Year ” Awards for Excellence 2013 – Finalist The Forrester Wave Seven Most Significant Online Testing Platform Providers 2013 Forbes 30 Under 30, Optimizely CEO Dan Siroker San Francisco Business Times #1 Best Place to Work 2014 San Francisco Business Times #2 Best Place to Work 2015 Official website

Kevin Gryboski

Kevin John Gryboski is a former Major League Baseball pitcher and current head coach of Wilkes University's baseball team. At Bishop Hoban High School in Wilkes-Barre, Gryboski was a two-sport star in both baseball and basketball. In baseball, he was an All-Conference All-Star pick. Gryboski pitched for Wilkes University in Pennsylvania. Gryboski was selected by the Seattle Mariners in the 16th round of the 1995 Major League Baseball draft. Gryboski, a right-handed pitcher, was acquired by the Atlanta Braves in January 2002 and traded to the Texas Rangers in July 2005 for minor league pitcher Matt Lorenzo. Gryboski was known as "Groundball" Gryboski while playing with the Braves, he was once suspended by the Texas Rangers for "inappropriate actions". In 2018, Gryboski became of head coach of the Wilkes University Colonels baseball team. Along with pitching with the Wilkes Colonels, Kevin helps every year with the Wilkes baseball clinic for 6-12 year olds, where he teaches them the fundamentals of pitching.

Gryboski is married to Leah and they have two children: KJ and Kaylee. Career statistics and player information from Baseball-Reference, or Retrosheet Kevin Gryboski at Baseball Almanac Kevin Gryboski - San Francisco Giants - MLB - Yahoo! Sports