Cyprenorphine is an opioid drug. It is related to more well-known opioids such as buprenorphine, used as an analgesic and for the treatment of opioid addiction, diprenorphine, used as an antidote to reverse the effects of other opioids. Cyprenorphine has mixed agonist–antagonist effects at opioid receptors, like those of buprenorphine; however the effects of cyprenorphine are somewhat different, as it produces pronounced dysphoric and hallucinogenic effects which limit its potential use as an analgesic. Cyprenorphine has been shown to suppress the intake of sweet solution but doesn't suppress the increase in food consumption that's produced by the alpha-2-adrenoceptor antagonist idazoxan. Idazoxan may lead to the release of endogenous opioid peptides and increase food intake, this effect is attenuated by -naloxone but not by the mu/delta-antagonist cyprenorphine
Edward Porter Williams was an American businessman who co-founded the Sherwin-Williams Company with Henry Sherwin. Born in Cleveland, Ohio, he graduated from Cleveland Central High School in 1859 earned a bachelor's and master's degree from Western Reserve College. Edward and his brother Charles joined the Army in 1862, along with the entire Western Reserve College and student alike, they were assigned to Company B, 85th Ohio and held a short-term assignment at Camp Chase guarding Confederate prisoners. He mustered out at Columbus and had to be carried there on a cot, as he was recovering from typhoid fever. Edward married Mary Louise Mason. Children: Edward Mason Williams, Sarah Granger Williams, Lewis Mason Williams, Reba Louise Williams, Walter Williams. In 1865, Edward and his brother Charles, along with Edward L Day entered the glass business in Kent, Ohio as Day & Williams, he left that company in 1870. Edward P. Williams was Executive Vice President and a member of the board of directors of the company at the time of his death.
Edward Porter Williams is buried at Lakeview Cemetery in Ohio. Edward Williams at Find a Grave
The SS British Premier was a tanker built by Palmers Shipbuilding and Iron Company in 1922, registered in London and operated by the British Tanker Company. During the Second World War, she was used on convoy duties to bring oil from the Persian Gulf around the Cape of Good Hope and to the United Kingdom She was part of Convoy SLS-60 in late December 1940, but was straggling behind the main group when she came under attack by a German U-boat and was sunk with heavy loss of life, her final convoy was to have taken her from Abadan to Swansea, via Freetown, which she reached on 22 December. Two days she was still straggling, when she was spotted by U-65, commanded by Hans-Gerrit von Stockhausen. At 16:41, U-65 sank British Premier, she went down with the loss of 32 of her crew, including her Master, Francis Dalziel, a gunner. There were thirteen survivors, nine of whom were picked up by the cruiser HMS Hawkins on 3 January 1941 and taken to Freetown; the remaining four were not picked up until 3 February, when they were rescued by the destroyer HMS Faulknor, having spent 41 days in an open boat, 25 of those days without any food.
"SS British Premier". Www.tynebuiltships.co.uk. Retrieved 13 March 2017