The Dahme is a river that flows through the German states of Brandenburg and Berlin. It is a left bank tributary of the River Spree and is 95 kilometres long; the source of the Dahme is near the eponymous town Dahme. The river flows north through the towns of Märkisch Prieros. At Märkisch Buchholz the river is joined by the Dahme Flood Relief Canal that diverts water from the upper reaches of the River Spree at Leibsch. At Prieros the Dahme is joined by two tributaries, the Storkower Gewässer on the right bank and the Teupitzer Gewässer on the left bank. Both of these tributaries comprise a chain of linked lakes. North of Prieros the Dahme flows through a number of lakes, including the Dolgenzee, Krüpelsee and Krimnicksee before reaching the city of Königs Wusterhausen; the fjord-like Zernsdorfer Lankensee joins the Krüpelsee as a right-bank tributary. A short section of the Dahme downstream of the Krimnicksee is called Staabe. At Königs Wusterhausen the River Notte joins as a left-bank tributary.
Downstream of Königs Wusterhausen the river is linked to the Möllenzugsee on the right bank, shortly thereafter by the linked Grosser Zug and Krossinsee on the same bank. The Dahme flows into the Zeuthener See, which links to the Seddinsee and Langer See at the outer Berlin suburb of Schmöckwitz; the Dahme flows out of the Langer See at its north-western end, shortly before it confluence with the River Spree at Köpenick, a historic town, now a suburb of Berlin. The Dahme is navigable as far upstream as Märkisch Buchholz, although the reach above Prieros is shallow and only used by leisure craft. Canoes and similar craft can by-pass a weir near Märkisch Buchholz and enter the Dahme Flood Relief Canal, navigable to its junction with the upper Spree; the Storkower Gewässer is navigable as far as the Scharmützelsee, the Teupitzer Gewässer as far as Teupitzersee. The River Notte is navigable, as are most of the lakes linked to, or traversed by, the river downstream of Prieros; the Oder-Spree Canal links with the Seddinsee near Schmöckwitz, with the Oder river, at Eisenhüttenstadt, thus providing a navigable connection between Berlin and the Oder, hence Poland.
Agrin is a large proteoglycan whose best-characterised role is in the development of the neuromuscular junction during embryogenesis. Agrin is named based on its involvement in the aggregation of acetylcholine receptors during synaptogenesis. In humans, this protein is encoded by the AGRN gene; this protein has nine domains homologous to protease inhibitors. It may have functions in other tissues and during other stages of development, it is a major proteoglycan component in the glomerular basement membrane and may play a role in the renal filtration and cell-matrix interactions. Agrin-targeted autoantibodies have been infrequently observed in myasthenia gravis. Agrin was first identified by the U. J. McMahan laboratory, Stanford University. During development in humans, the growing end of motor neuron axons secrete; when secreted, agrin binds to several receptors on the surface of skeletal muscle. The receptor which appears to be required for the formation of the neuromuscular junction is called the MuSK receptor.
MuSK is a receptor tyrosine kinase - meaning that it induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself and on proteins that bind the cytoplasmic domain of the receptor. In addition to MuSK, agrin binds several other proteins on the surface of muscle, including dystroglycan and laminin, it is seen that these additional binding steps are required to stabilize the NMJ. The requirement for Agrin and MuSK in the formation of the NMJ was demonstrated by knockout mouse studies. In mice that are deficient for either protein, the neuromuscular junction does not form. Many other proteins comprise the NMJ, are required to maintain its integrity. For example, MuSK binds a protein called "dishevelled", in the Wnt signalling pathway. Dvl is additionally required for MuSK-mediated clustering of AChRs, since inhibition of Dvl blocks clustering; the nerve secretes agrin. It seems that the MuSK receptor recruits casein kinase 2, required for clustering. A protein called rapsyn is recruited to the primary MuSK scaffold, to induce the additional clustering of acetylcholine receptors.
This is thought of as the secondary scaffold. A protein called Dok-7 has shown to be additionally required for the formation of the secondary scaffold. There are three potential heparan sulfate attachment sites within the primary structure of agrin, but it is thought that only two of these carry HS chains when the protein is expressed. In fact, one study concluded that at least two attachment sites are necessary by inducing synthetic agents. Since agrin fragments induce acetylcholine receptor aggregation as well as phosphorylation of the MuSK receptor, researchers spliced them and found that the variant did not trigger phosphorylation, it has been shown that the G3 domain of agrin is plastic, meaning it can discriminate between binding partners for a better fit. Heparan sulfate glycosaminoglycans covalently linked to the agrin protein have been shown to play a role in the clustering of AChR. Interference in the correct formation of heparan sulfate through the addition of chlorate to skeletal muscle cell culture results in a decrease in the frequency of spontaneous acetylcholine receptor clustering.
It may be that rather than binding directly to the agrin protein core a number of components of the secondary scaffold may interact with its heparan sulfate side-chains. A role in the retention of anionic macromolecules within the vasculature has been suggested for agrin-linked HS at the glomerular or alveolar basement membrane. Human AGRN genome location and AGRN gene details page in the UCSC Genome Browser
Cuckney is a village and former civil parish, now in the parish of Norton and Cuckney, in the Bassetlaw district of Nottinghamshire, located between Worksop and Market Warsop. The A60 road connects Market Cuckney via Cuckney Hill; the civil parish was merged with Norton to form Cuckney. The grounds of Cuckney Parish Church, a Grade I listed building, contain the remains of Cuckney Castle. George Sitwell, Ironmaster mined iron locally and he built a blast furnace here in the seventeenth century. In 1853 there were two large watermills on the river Poulter in Cuckney, one for cotton, another for corn. An earlier cotton mill had burnt down in 1792; the upstream mill is now a primary school. Cuckney Church of England Primary School has 140 pupils on its roll. Link about Cuckney
Rimegepant is a medication for the treatment of an acute migraine with or without aura in adults. However, it is not to be used prophylactically. In the US, it is marketed under the brand name, Nurtec ODT, it is not indicated for the preventive treatment of migraine. It is taken by mouth, it can provide relief for up to 48 hours, according to Biohaven. It is not a narcotic and has no addictive potential, will not be designated a controlled substance, it works by blocking CGRP receptors. 86% of patients did not require additional rescue medication within 24 hours of a single dose of Nurtec. All this info was obtained from a press release from Biohaven. Rimegepant was approved for use in the United States as of February 27th, 2020 by the U. S. Food and Drug Administration to be marketed by Biohaven Pharmaceuticals. Rimegepant is a small molecule calcitonin gene-related peptide receptor antagonist. Discovered at Bristol-Myers Squibb, it was under development by Biohaven Pharmaceuticals and is now being marketed in the US by the same company after receiving FDA approval late February 2020.
Ogbeni Rauf Adesoji Aregbesola is the current Minister of the Federal Ministry of Interior of Nigeria. Before that he was the fourth civilian governor of Osun State, he is a native of Osun. Aregbesola is a Muslim born into a family of Christians, he had his secondary education in Ondo State. He attended The Polytechnic, where he studied Mechanical Engineering and graduated in 1980. Aregbesola's interest and involvement in politics dates back to his undergraduate days when he was Speaker of the Students' Parliament at The Polytechnic and the President of the Black Nationalist Movement, he was an active supporter of other progressive students' movements nationwide, which earned him, for instance, a life membership in the National Association of Technological Students. In June 1990, he became an elected delegate to the Social Democratic Party Inaugural Local Government Area Congress. In July of the same year, he was a delegate to its first National Convention in Abuja. Aregbesola, as a pro-democracy and human rights activist, was a major participant in the demilitarization and pro-democracy struggles of the 1990s in Nigeria.
Upon the return of the country to democratic rule in 1999, he was a ranking member of the Alliance for Democracy, led by Senator Bola Tinubu, who would go on to become governor of Lagos State in the same year. Aregbesola was Director of the Bola Ahmed Tinubu Campaign Organisation, who drove the electoral victory of Bola Tinubu in 1999, he performed a similar feat with the platform of the Independent Campaign Group, with which he ensured the re-election of Tinubu for a second term in office. Upon Tinubu's inauguration as governor, Aregbesola was appointed the Commissioner of Works and Infrastructure, which included supervision of the Public Works Corporation and the State Electricity Board, he not only oversaw a large investment in road infrastructure in the state, but birthed the master plan that has served as a basis for the infrastructural development and expansion observed in Lagos after Tinubu's two terms in office. Following Tinubu's tenure as governor of Lagos State, Aregbesola ran on the platform of the Action Congress for the Governorship of Osun State in the April 2007 elections.
Aregbesola had to withstand several attempts by the incumbent state government to cut short his ambition, from the failed attempt to abort the launch of Oranmiyan, the campaign organisation of Aregbesola, fixed for Oshogbo Stadium until the state government deployed force to stop the event. On 16 May 2005, a major financier of Aregbesola's campaign, Alhaji Sulaimon Hassan-Olajoku, was assassinated at Gbongan Junction after attending a series of political events to mobilise support of Aregbesola. Aregbesola narrowly escaped assassination plots in Ilesha in 2005 and on Osogbo Oroki Day in 2006. In addition, a petition led to the arrest and detention of Aregbesola for three weeks by men of the Lagos State Police Command until a High Court ruled in favour of him and awarded a penalty of N5m against the police for wrongful arrest and detention. After incumbent Olagunsoye Oyinlola was declared the winner of the 14 April 2007 elections, Aregbesola proceeded to the courts to overturn this outcome.
In May 2008, Aregbesola called over 100 witnesses and tendered 168 exhibits in his petition before the Election Petitions Tribunal, alleging violence and ballot box stuffing in the election. In an October 2008 interview, he described Oyinlola as "a bully who came from a reactionary military arm", stating that Oyinlola had done nothing for the people of Osun state, he claimed that 12 people had died in the election violence. In August 2009 the police arrested Aregbesola for involvement in the alleged forgery of a police report on the conduct of the elections; that month he sought bail so that he could perform the lesser Hajj in Saudi Arabia. In August 2010 the police summoned him to make a statement about a 14 June 2007 bomb explosion near the ministry of water resources. Aregbesola denied any involvement. Having gone through the tribunal of first instance, an appeal and a retrial tribunal, the second appeal court, delivering judgment on 26 November 2010, declared Aregbesola governor and ordered that he be sworn in the next day.
The Court was presided over by Justice Clara Bata Ogunbiyi, flanked by four other justices. L. Garba, P. A. Galinge, Chima Centus Nweze, A. Jauro; the court unanimously nullified the election results of the 10 local governments pleaded for by Aregbesola and set aside the judgement of a lower tribunal which had confirmed the election of Oyinlola, after the deductions of the cancelled votes had left Oyinlola with 172,880 votes and Aregbesola with 198,799, thereby returning Aregbesola as the duly elected governor of the state, three years after the elections. The Governor of Edo State, Comrade Adams Oshiomhole, offered his congratulations for the belated recognition of his election victory. Oyinlola alleged that there was telephone contact between Justice Ayo Salami, head of the Nigerian Court of Appeal, the Action Congress of Nigeria chieftains prior to the decision and urged the Attorney General of the Federation "to exercise his power of public prosecution entrenched in Section 174 and of the 1999 Constitution by initiating legal action against MTN Nigeria Limited" after he petitioned the National Judicial Council.
The Court rejected his application for Salami's call log. In a reply to a memo submitted by Aregbesola to a Truth and Reconciliation committee he had set up to look into the alleged atrocities committed by the previous government, Oyinlola described Aregbesola's claims as lies. In his fi
Gina Knee Brook, née Gina Schnauffer and better known as Gina Knee, was a twentieth century American artist who lived and worked in New Mexico, the American South and Long Island, New York. Born Gina Schnaufer to an affluent Marietta, Ohio family for whom art was not considered a serious activity, she studied at Smith College and left an unhappy first marriage. On seeing a group of John Marin's New Mexico watercolors in a 1930 New York gallery exhibition, she was inspired to move to the state by his depictions of Native American Pueblo life. Arriving in New Mexico in 1931, Gina Schnaufer spent her first year in the region attending Native American ceremonials and dances, paying close attention to the colors and patterns in the scenes she witnessed. On her visits to various Pueblos, Schnaufer was accompanied by a young Canadian artist, Ernest Knee, a photographer whose landscape images are a record of New Mexico's photographic history. Although there was a nine-year age difference, Schnaufer married the younger artist in 1933, is best known by his surname despite a subsequent 1945 marriage to the painter Alexander Brook.
The two made a home in the vacant house of Walter Mruk, one of Santa Fe's Los Cinco Pintores, were welcomed into the burgeoning but male Santa Fe arts community. Brought up to defer to men and their interest, she knew that "...it was one thing to call oneself an artist in a town of artists and quite another to rearrange her life priorities into a list headed by'ART'." Moving north to the Tesuque Valley, the Knees built a home using local materials that welcomed the outside in, with portals and patios aplenty. Once the house was complete, Knee concentrated on her painting. Aware that she would always be an outsider to the local Pueblo culture, she turned to the New Mexico landscape for inspiration, her early landscapes were traditional and imitative of her mentors, but she progressed and in 1933, she joined a new group of artists who named themselves the Rio Grande Painters, regionalists whose work "is composed of painters bound together by a preference for the Southwest, both as a place of residence and a perpetual mine of paintable material."
Knee was attuned not only to the landscape itself but to the spiritual connection to the land that she had witnessed in the New Mexico Pueblos. As the 1930s drew to a close, Knee began to move away from formalist figure-ground painting traditions and to more abstracted work a meandering mix of color and forms, with calligraphic lines and agile brushwork. In the 1940s her husband left for California to work in the war effort and she remained in New Mexico. After meeting dealer Marian Willard, she was invited to mount her first solo exhibition at Willard's Gallery in New York. Willard introduced her to the work of Paul Klee, the fantasy element so prominent in Klee's oeuvre began to appear in Knee's work, she began to incorporate mixed media, adding gouache and tempera to her preferred medium of watercolor and adopting more modernist conventions. Her work was both praised for "restraint lovely color" and demeaned by gender-specific comments that likened her work to "samplers" that were "replete with little things" but overall the results were encouraging.
In late 1942, Knee decided to join her husband in Los Angeles, where they explored the city and delved into the West Coast art scene, meeting luminaries like Man Ray and Thomas Mann. Ernest Knee became the personal photographer to the reclusive Howard Hughes; the change in their lifestyle, he going off to work daily and she faced with household chores in a wartime era, led to a dark period which lifted when she began to create work for a California gallery owned by Dalzell Hatfield. The innovative California watercolor movement was inspirational, Knee began to visit the beaches for inspiration, resulting in work, sometimes obvious and at other times, more subtle, her work was praised by Walter Arensberg, much of whose collection now resides at the Philadelphia Museum of Art. As her art career progressed, her marriage disintegrated, Ernest Knee struck up a relationship with another woman. In 1943, convinced that her marriage was over, after fulfilling her commitment to provide a body of work for a New York exhibit at Marian Willard's Gallery, Knee returned to New Mexico.
Knee spent much of the autumn of 1943 in New York, where she began a new life with the painter Alexander Brook. They settled in Savannah, where Brook had lived with his former wife, renovating an old warehouse into a living space with two separate studios. An exhibit at the E. B. Crocker Gallery Sacramento partnered Knee with modernist painters Lionel Feininger, Mark Tobey and Morris Graves, her subtle and contemplative works contributed to a harmonious exhibition. In a c.1950 letter to a friend, she noted that "Maybe its easiest to say that in adjusting to a new life, I had to cut the lovely strands of the past," and she sold her New Mexico home. While she was used to the differences in the lives of the Anglo and Native American residents of New Mexico, the South was new and different, she tried to evoke in her work the live of southern blacks. For the first time, she began to paint with oils. With the knowledge that she could scrape away and re-do allowed her new ways to explore texture and brushstrokes, telling gallery owner Willard in a letter that she no longer felt "in tune with watercolor painting at all when I attempt it."
Knee and Brook divided their time between Savannah and New York, interspersing it with road-trips to locations where Brook had portrait commissions. After a few years, they were ready to settle down in one spot, they chose a meadow