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John Carroll University

John Carroll University is a private Jesuit university in University Heights, Ohio. It is an undergraduate, liberal arts institution accompanied by the John M. and Mary Jo Boler College of Business. John Carroll has an enrollment of 3,650 students; the university offers undergraduate programs in the liberal arts and business, in selected areas at the master's level. John Carroll offers 70 academic programs of study for undergraduate students; the university has been ranked in the top 10 of Midwest regional universities by U. S. News & World Report's annual guide, "America's Best Colleges," for 29 consecutive years. John Carroll University was founded in 1886 by the Society of Jesuits under the title of St Ignatius College as a "college for men", it has been in continuous operation as a degree-granting institution since that time. Founded as the 19th of 28 Jesuit colleges and universities in the United States, it is a member of the Association of Jesuit Colleges and Universities, it was founded 97 years after Georgetown University, the first Catholic Jesuit University in the United States.

In 1923 the college was renamed John Carroll University, honoring the first archbishop of the US Catholic Church, who founded Georgetown University. In 1935, it was moved from its original location on the west side of Cleveland to its present site in University Heights, a suburb 10 miles east of downtown Cleveland. However, the high school section retained the original name and continues to operate on the original site in Cleveland; the city of University Heights had been renamed from "Idlewood" during the construction of the campus. During World War II, John Carroll was one of 131 colleges and universities nationally that took part in the V-12 Navy College Training Program which offered students a path to a Navy commission. In September 1968, the university made the transition from full-time male enrollment to a coeducational institution, admitting women to the College of Arts and Sciences for the first time. In recent years, the university has undergone extensive expansion. In 2003, the university opened the $66 million, 265,000 ft² Dolan Center for Science and Technology, named after alumnus Charles Dolan, founder of Cablevision and HBO, his wife Helen Dolan.

The couple met. In 2011, the university completed the removal of the Bohannon Science building and celebrated the Hamlin Quad enhancement project; the Jesuits who founded St. Ignatius College were exiles from Germany, forced out by Bismarck's Kulturkampf, they brought with them the traditional structure of the Jesuit college as an extension of the apostolate of the religious community to prepare the student morally as well as intellectually. The principal instrument of this education was the classical course of seven years, in which the first three years were devoted to learning languages as necessary tools; the student was considered prepared for university work. The next four years were devoted to the study of classical literature and Latin and Greek prose and poetry, to developing the ability to express one's self in these languages, as well as in the vernacular, orally and in writing; the final year was devoted to philosophy. There were electives in the sciences and geography, as well as other subjects.

If the student completed only six years, a certificate was given. Completion of the year of philosophy made the student eligible for the baccalaureate degree, which the college was empowered to grant when it was chartered in 1890; the first two degrees were awarded in 1895. John Carroll's core value and mission emphasizes social justice and service to the community and the broader world; the university follows Jesuit traditions by focusing on educating the “whole” student, or the intellectual, spiritual and physical development of each student. Although its curriculum and community are shaped by its Jesuit and Catholic nature, it welcomes faculty and students of all faiths and of no faith; the university announced in December, 2017 that its board of directors had named the school's first non-Jesuit president, Michael D. Johnson, PhD. Johnson had been the provost at Babson College in Massachusetts, he began his tenure on July 1, 2018 and was inaugurated on September 6, 2018. John Carroll University is organized into two schools: the College of Arts and Sciences and the AACSB-accredited Boler College of Business, each defining its own academic programs under the auspices of the Academic Vice President.

All students need to fulfill the requirements in the core curriculum, as well as those required by their major field of study. The university requires a rigorous liberal arts core for all undergraduate students. Among the requirements are public speaking, English composition, two philosophy courses, two religious studies courses, a social justice course, a global course, a foreign language requirement; the Core Curriculum in the Liberal Arts of John Carroll is informed by the principles that issue from the university's mission as a Jesuit liberal arts institution of higher learning. Accordingly, the Core emphasizes the development of whole human persons who are educated in the humanizing arts and sciences. Moreover, it promotes the integration of faith and reason by imparting a deeper knowledge of and respect for the students' own cultural and religious traditions as well as those of others, it highlights the development of intellect and leadership, the responsible social actions which flow from them.

As a means to achieve these and other goals significant to the university's mission, the Core has a distribu

Jean Gilbert Victor Fialin, duc de Persigny

Jean-Gilbert Victor Fialin, Duc de Persigny was a statesman of the Second French Empire. Fialin was born at Saint-Germain-Lespinasse in the Loire, where his father was Receiver of Taxes, was educated at Limoges, he entered Saumur Cavalry School in 1826, becoming Maréchal des logis in the 4th Hussars two years later. The role played by his regiment in the July Revolution of 1830 was regarded as insubordination, resulting in Fialin being dismissed from the army, he became a journalist, after 1833, a strong Bonapartist, assuming the style vicomte de Persigny, said to be dormant in his family. He was involved in the abortive Bonapartist coups at Strasbourg in 1836 and at Boulogne-sur-Mer in 1840. After the second coup, he was arrested and condemned to twenty years' imprisonment in a fortress, commuted to mild detention at Versailles. There he wrote a book to prove that the Egyptian pyramids were built to prevent the Nile from silting up; the book was published in 1845 under the title De la destination et de l'utilité permanente des Pyramides.

During the 1848 Revolution, Fialin was arrested by the Provisional Government. After his release, he played a prominent part in securing Prince Louis-Napoleon Bonaparte's election to the presidency. Together with Morny and Marshal Saint Arnaud he plotted the Restoration of the Empire, was a devoted adherent of Napoleon III, he succeeded Morny as French Minister of the Interior in January 1852, became Senator that year. He resigned in 1854, was appointed Ambassador to London the next year, a post he occupied with a short interval until 1860, when he resumed the portfolio at the Interior Ministry, but the growing influence of his rival Rouher prompted his resignation in 1863, after which the Emperor created him a Duke. A more dangerous enemy than Rouher was Empress Eugénie, whose marriage Fialin had opposed and whose presence on the Council he deprecated in a memorandum, leaked to the Empress, he sought in vain to see Napoleon before the Franco-Prussian War in 1870, the breach was further widened when the master and servant were in exile.

Persigny returned to France in 1871 and died in Nice on 12 January 1872. A devoted fanatical follower of Louis-Napoleon, whose service dated back to the future Emperor's wilderness years of exile and imprisonment, Persigny always stood out among the Emperor's motley political entourage as the most passionate ideologue of Bonapartism. Hence the Emperor's famous wry comment: "The Empress is a Legitimist, Morny is an Orleanist, Prince Napoleon is a Republican, I myself am a Socialist. There is only one Bonapartist, Persigny - and he is mad!" This article incorporates text from a publication now in the public domain: Chisholm, Hugh, ed.. "Persigny, Jean Gilbert Victor Fialin, Duc de". Encyclopædia Britannica. Cambridge University Press. Mémoires du duc de Persigny, edited by Count Henri de Laire d'Espagny, his former secretary. Le duc de Persigny et les doctrines de l'empire, a eulogistic life by Joseph Delaroa. L'empire libéral, études, récits, souvenirs, by Emile Ollivier

BLAT (bioinformatics)

BLAT is a pairwise sequence alignment algorithm, developed by Jim Kent at the University of California Santa Cruz in the early 2000s to assist in the assembly and annotation of the human genome. It was designed to decrease the time needed to align millions of mouse genomic reads and expressed sequence tags against the human genome sequence; the alignment tools of the time were not capable of performing these operations in a manner that would allow a regular update of the human genome assembly. Compared to pre-existing tools, BLAT was ~500 times faster with performing mRNA/DNA alignments and ~50 times faster with protein/protein alignments. BLAT is one of multiple algorithms developed for the analysis and comparison of biological sequences such as DNA, RNA and proteins, with a primary goal of inferring homology in order to discover biological function of genomic sequences, it is not guaranteed to find the mathematically optimal alignment between two sequences like the classic Needleman-Wunsch and Smith-Waterman dynamic programming algorithms do.

It is similar to the heuristic BLAST family of algorithms, but each tool has tried to deal with the problem of aligning biological sequences in a timely and efficient manner by attempting different algorithmic techniques. BLAT can be translated nucleotide sequences, it is designed to work best on sequences with great similarity. The DNA search is most effective for primates and the protein search is effective for land vertebrates. In addition, protein or translated sequence queries are more effective for identifying distant matches and for cross-species analysis than DNA sequence queries. Typical uses of BLAT include the following: Alignment of multiple mRNA sequences onto a genome assembly in order to infer their genomic coordinates. Provided the two species are not too divergent, cross-species alignment is effective with BLAT; this is possible because BLAT does not require perfect matches, but rather accepts mismatches in alignments. However, it is not the tool of choice for these types of alignments.

BLASTP, the Standard Protein BLAST tool, is more efficient at protein-protein alignments. BLAT is designed to find matches between sequences of length at least 40 bases that share ≥95% nucleotide identity or ≥80% translated protein identity. BLAT is used to find regions in a target genomic database which are similar to a query sequence under examination; the general algorithmic process followed by BLAT is similar to BLAST's in that it first searches for short segments in the database and query sequences which have a certain number of matching elements. These alignment seeds are extended in both directions of the sequences in order to form high-scoring pairs. However, BLAT uses a different indexing approach from BLAST, which allows it to scan large genomic and protein databases for similarities to a query sequence, it does this by keeping an indexed list of the target database in memory, which reduces the time required for the comparison of the query sequences with the target database. This index is built by taking the coordinates of all the non-overlapping k-mers in the target database, except for repeated k-mers.

BLAT builds a list of all overlapping k-mers from the query sequence and searches for these in the target database, building up a list of hits where there are matches between the sequences. There are three different strategies used in order to search for candidate homologous regions: The first method requires single perfect matches between the query and database sequences i.e. the two k-mer words are the same. This approach is not considered the most practical; this is because a small k-mer size is necessary in order to achieve high levels of sensitivity, but this increases the number of false positive hits, thus increasing the amount of time spent in the alignment stage of the algorithm. The second method allows at least one mismatch between the two k-mer words; this decreases the amount of false positives, allowing larger k-mer sizes which are less computationally expensive to handle than those produced from the previous method. This method is effective in identifying small homologous regions.

The third method requires multiple perfect matches. As Kent shows, this is a effective technique capable of taking into consideration small insertions and deletions within the homologous regions; when aligning nucleotides, BLAT uses the third method requiring two perfect word matches of size 11. When aligning proteins, the BLAT version determines the search methodology used: when the client/server version is used, BLAT searches for three perfect 4-mer matches; some of the differences between BLAT and BLAST are outlined below: BLAT indexes the genome/protein database, retains the index in memory, scans the query sequence for matches. BLAST, on the other hand, builds an index of the query sequences and searches through the database for matches. A BLAST variant called MegaBLAST indexes


Kortedala is a district residential, in the north-eastern part of Gothenburg in western Sweden. The area houses a population of around 10,000 inhabitants and is one of the typical 1950s suburbs of Gothenburg; the area is lush and green with many trees and parks. Kortedala has Gothenburg's largest ice-skating rink named, a big sports centre named Alelyckan. There are three smaller ones and the bigger Kortedala Torg. Kortedala is on the tram lines 7 or 11, line 6 terminating at Aprilgatan. In 2007, Swedish musician Jens Lekman released, he wrote a song called Tram #7 to Heaven about the tram to Bergsjön, which travels through Kortedala. Kortedala Torg - The big square. Isdala - The ice rink. Citytorget - Another square, where many restaurants and fast food establishments are located. For example, the only Italian pizzeria in eastern Gothenburg is situated here. Almenacksplan - The local football field, where the local club Kortedala IF plays its league games

Jaeden Martell

Jaeden Martell known as Jaeden Lieberher, is an American actor. He has portrayed roles in the 2017 and 2019 film adaptations of the Stephen King novel It, in the 2019 mystery film Knives Out. Jaeden was born on January 4, 2003, the son of Wes Lieberher, a Los Angeles-based Executive Chef, Angela Teresa Martell, his maternal grandmother, Chisun Martell, is Korean. He grew up in South Philadelphia. In 2011, when he was eight years old, he moved to Los Angeles. In the first six years of his career, he was credited exclusively under his family name, Jaeden Lieberher. In 2019, he switched to Jaeden Martell. Martell's first acting role was in a commercial for Hot Wheels, he appeared in several other commercials after that, including Google,, Liberty Mutual, Verizon Fios and General Electric. His first major feature film role was in 2014's St. Vincent. Murray recommended Martell to Cameron Crowe for the director's 2015 film, Aloha, he played the title character in the 2017 film The Book of Henry.

Martell received further recognition for his starring role as Bill Denbrough in the 2017 supernatural horror film It and its 2019 follow-up It Chapter Two. In 2019, Martell was a part of Rian Johnson's ensemble cast in the murder-mystery film Knives Out. In March 2019, now credited as Martell, he joined the cast of the Apple miniseries Defending Jacob, based on the William Landay novel of the same name. Jaeden Martell on Instagram Jaeden Martell on IMDb