Deoxysarpagine hydroxylase

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Deoxysarpagine hydroxylase
EC number1.14.13.91
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum

In enzymology, a deoxysarpagine hydroxylase (EC is an enzyme that catalyzes the chemical reaction

10-deoxysarpagine + NADPH + H+ + O2 sarpagine + NADP+ + H2O

The 4 substrates of this enzyme are 10-deoxysarpagine, NADPH, H+, and O2, whereas its 3 products are sarpagine, NADP+, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is 10-deoxysarpagine,NADPH:oxygen oxidoreductase (10-hydroxylating). This enzyme is also called DOSH.


  • Yu B, Ruppert M, Stockigt J (2002). "Deoxysarpagine hydroxylase--a novel enzyme closing a short side pathway of alkaloid biosynthesis in Rauvolfia". Bioorg. Med. Chem. 10 (8): 2479&ndash, 83. doi:10.1016/S0968-0896(02)00126-8. PMID 12057637.